Catalog No.
EHC81201
Expression system
Insect Cells
Species
Homo sapiens (Human)
Protein length
Ser87-Leu647
Predicted molecular weight
60.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10515
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, 2.3.1.12, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, PBC, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, Pyruvate dehydrogenase complex component E2, PDC-E2, PDCE2, DLAT, DLTA
Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method., PMID:40491693
Mycobacterium tuberculosis stimulates cuproptosis by regulating Lnc-Gm5532 to target FDX1 for bacteria intracellular survival., PMID:40449270
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis., PMID:40378837
Copper's new role in cancer: how cuproptosis-related genes could revolutionize glioma treatment., PMID:40355831
[Effect and mechanism of Shenmai Injection in regulating copper death in myocardial fibrosis in rats]., PMID:40350947
Discovery of Cu(II)-Dipyridophenazine Complex for Synergistic Cuproptosis/Chemodynamic Therapy via Disrupting the Tricarboxylic Acid (TCA) Cycle in Metastatic TNBC., PMID:40348584
Role of DLAT in cuproptosis and autophagy in hippocampal tissue of PTSD rats with high-voltage electrical burns., PMID:40319822
Hypoxia-induced autophagy attenuates ferredoxin 1-mediated cuproptosis in colorectal cancer cells., PMID:40294285
The Role of Cuproptosis in Hyperoxia-Induced Lung Injury and Its Potential for Treatment., PMID:40195958
Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis., PMID:40186145
Copper oxide nanoparticles induce pulmonary inflammation via triggering cellular cuproptosis., PMID:40180017
Induction of Cuproptosis by Dichloromethane Extract From Patrinia scabiosaefolia Fisch on K562 Cells., PMID:40177825
Expression of SLC2A1 is upregulated in a mouse model of age-related hearing loss., PMID:40157470
Atovaquone-Coordinated Copper-Polyphenol Nanoplatform Orchestrates Dual Metabolic Interference for Synergistic Cuproptosis and Apoptosis., PMID:40148125
Pyruvate Regulates the Expression of DLAT to Promote Follicular Growth., PMID:40136693
PER2 interaction with HSP70 promotes cuproptosis in oral squamous carcinoma cells by decreasing AKT stability., PMID:40113747
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism., PMID:40112809
Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis., PMID:40089548
Effect of spermidine on cuproptosis in follicular granulosa cells., PMID:40072410
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis., PMID:40054467
Molecular mimicry-driven autoimmunity in chronic rhinosinusitis with nasal polyps., PMID:39984131
Induced cuproptosis by targeting the ESCRT-III complex potentiates copper-based control of smut diseases., PMID:39984090
DLAT activates EMT to promote HCC metastasis by regulating GLUT1-mediated aerobic glycolysis., PMID:39979835
The Potential Mechanism of Cuproptosis in Hemocytes of the Pacific Oyster Crassostrea gigas upon Elesclomol Treatment., PMID:39936990
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC., PMID:39930648
Aprocitentan mitigates doxorubicin-induced cardiotoxicity by inhibiting cuproptosis, oxidative stress, and mitochondrial impairments via the activation of sirtuin 7., PMID:39930646
Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis., PMID:39924054
MT2A promotes angiogenesis in chronically ischemic brains through a copper-mitochondria regulatory mechanism., PMID:39915841
Mitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth., PMID:39885202
Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction., PMID:39870300
Identification of a novel cuproptosis inducer that induces ER stress and oxidative stress to trigger immunogenic cell death in tumors., PMID:39848344
A high-contrast NIR excitation probe for monitoring Cu2+ in the endoplasmic reticulum for synergistic cuproptosis and ferroptosis anticancer therapy., PMID:39831720
Metallothionein rescues doxorubicin cardiomyopathy via mitigation of cuproptosis., PMID:39793852
The study on cuproptosis in Alzheimer's disease based on the cuproptosis key gene FDX1., PMID:39759399
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development., PMID:39747033
Serum DLAT Is a Potential Diagnostic Marker in AFP-Negative HCC., PMID:39710381
Assembly of a biomimetic copper-based nanocomplex for alleviating hypoxia to enhance cuproptosis against osteosarcoma and lung metastasis., PMID:39710219
Novel insights into cuproptosis in alcoholic liver disease using bioinformatics analysis and experimental validation., PMID:39709914
Prognostic value and potential biological function of PMSD11 in lung adenocarcinoma., PMID:39678883
Cuproptosis and Serine Metabolism Blockade Triggered by Copper-Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy., PMID:39676407
Role of immune-related endoplasmic reticulum stress genes in sepsis-induced cardiomyopathy: Novel insights from bioinformatics analysis., PMID:39671358
Vasoactive intestinal peptide induces metabolic rewiring of human-derived cytotrophoblast cells to promote cell migration., PMID:39653085
Tumor microenvironment-regulated nanoplatform for enhanced chemotherapy, cuproptosis and nonferrous ferroptosis combined cancer therapy., PMID:39652201
Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling., PMID:39567863
[The role of peritumoral electroacupuncture in regulating cuproptosis for sensitization of chemotherapy efficacy in mice with triple-negative breast cancer]., PMID:39557431
Autoantibodies Against Dihydrolipoamide S-Acetyltransferase Are Not Associated With Immune-Mediated Neuropathies., PMID:39556782
PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy., PMID:39554839
The Role of Heat Shock Factor 1 in Preserving Proteomic Integrity During Copper-Induced Cellular Toxicity., PMID:39519208
Effect of cuproptosis on acute kidney injury after cardiopulmonary bypass in diabetic patients., PMID:39493567
For research use only. Not for human or drug use.
