Catalog No.
YHA69701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr116-His198
Predicted molecular weight
22.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43521
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BCL2L11, Bcl-2-like protein 11, Bcl2-interacting mediator of cell death, BIM, Bcl2-L-11
Holothurian Glycosaminoglycan (hGAG) Promoted Bim-Induced Apoptosis in Human Lung Adenocarcinoma A549 Cell Line Through Inhibition of Akt-Mediated FOXO3a Translocation., PMID:40474596
Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANoptosis Inhibition., PMID:40463856
C1QBP promotes apoptosis of goat fetal turbinate cells via inhibiting the expression of TRIM5 or TNFSF10., PMID:40454173
TRIM71 bound hsa-miR-30b-5p restores mitochondrial function in a cellular model of Parkinson's disease., PMID:40398685
SRSF1 and SRSF2 synergistically regulate Bim expression to mediate glucocorticoid-induced apoptosis in osteoblasts., PMID:40381239
The effect of plasma exosomal microRNA- 148a- 3p on the CD4+ T cell function and its mechanism in the pathogenesis of psoriasis., PMID:40261424
A kinase-independent Bcr-Abl function mediating an Hsp70-Bim protein-protein interaction in chronic myeloid leukemia., PMID:40250683
Structural basis of BAK sequestration by MCL-1 in apoptosis., PMID:40187349
[Mechanism of BIM-induced ibrutinib resistance in chronic lymphocytic leukemia]., PMID:40134198
Apolipoprotein A1 deficiency increases macrophage apoptosis and necrotic core development in atherosclerotic plaques in a Bim-dependent manner., PMID:40120762
Integrating network pharmacology and experimental validation to explore the potential mechanism by which resveratrol acts on osimertinib resistance in lung cancer., PMID:40041411
Collaborative orchestration of BH3-only proteins governs Bak/Bax-dependent hepatocyte apoptosis under antiapoptotic protein-deficiency in mice., PMID:39994353
Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors., PMID:39966387
The role of BIM gene deletion in ALK-mutated Non-small cell lung cancer treated with alectinib., PMID:39932597
Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice., PMID:39824797
ECM stiffness regulates lung fibroblast survival through RasGRF1-dependent signaling., PMID:39793891
Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization., PMID:39747661
TGFβ signaling sensitizes MEKi-resistant human melanoma to targeted therapy-induced apoptosis., PMID:39709491
YAP/TAZ mediates resistance to KRAS inhibitors through inhibiting proapoptosis and activating the SLC7A5/mTOR axis., PMID:39704172
IRX-related homeobox gene MKX is a novel oncogene in acute myeloid leukemia., PMID:39689089
A multidimensional toolkit for elucidating temporal trajectories in cell development in vivo., PMID:39611743
MG132 inhibits proliferation and induces apoptosis of acute lymphoblastic leukemia via Akt/FOXO3a/Bim pathway., PMID:39586583
CDK4 gene copy number increase and concurrent genetic changes in acral melanoma of a Chinese cohort., PMID:39472269
The BIM deletion polymorphism potentiates the survival of leukemia stem and progenitor cells and impairs response to targeted therapies., PMID:39438588
Bim Expression Influences Choroidal Endothelial Cell Characteristics and Their Response to Therapeutic Intervention., PMID:39408582
Jieduquyuziyin prescription alleviates lupus development via inhibiting neddylation pathway to promote Bim-induced apoptosis of double negative T cells., PMID:39362327
Ubiquitin-independent degradation of Bim blocks macrophage pyroptosis in sepsis-related tissue injury., PMID:39349939
Bax expression impacts postnatal retinal vascular development and hyperoxia sensitivity., PMID:39307450
Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins., PMID:39300221
UID-Dual Transcriptome Sequencing Analysis of the Molecular Interactions between Streptococcus agalactiae ATCC 27956 and Mammary Epithelial Cells., PMID:39272372
The role of the miR-30a-5p/BCL2L11 pathway in rosmarinic acid-induced apoptosis in MDA-MB-231-derived breast cancer stem-like cells., PMID:39239646
Hinokiflavone resists HFD-induced obesity by promoting apoptosis in an IGF2BP2-mediated Bim m6A modification dependent manner., PMID:39214307
Configuration of two cysteine residues in a ring within a stapled Bim peptide affects the secondary structure and apoptotic activity., PMID:39127242
Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms., PMID:39095579
Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer., PMID:39025835
Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy., PMID:39012838
Notopterygium Incisum Extract Promotes Apoptosis by Preventing the Degradation of BIM in Colorectal Cancer., PMID:38967889
METTL14-Mediated Bim mRNA m6A Modification Augments Osimertinib Sensitivity in EGFR-Mutant NSCLC Cells., PMID:38953880
Modeling the Binding of Anticancer Peptides and Mcl-1., PMID:38928234
TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription., PMID:38822080
Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy., PMID:38806674
Fbxo45 facilitates the malignant progression of breast cancer by targeting Bim for ubiquitination and degradation., PMID:38773471
The Study of SRSF1 Regulates Abnormal Alternative Splicing of BCL2L11 and the Role in Refractory Acute Myeloid Leukemia., PMID:38763139
Apoptosis Pathway-Associated Proteins Are Frequently Expressed in Melanoma: A Study of 32 Cases With Focus on Acral Lentiginous Melanoma., PMID:38718197
Blockage of BCL-XL overcomes venetoclax resistance across BCL2+ lymphoid malignancies irrespective of BIM status., PMID:38713893
Identification of Plasma hsa_circ_0001230 and hsa_circ_0023879 as Potential Novel Biomarkers for Focal Segmental Glomerulosclerosis and circRNA-miRNA-mRNA Network Analysis., PMID:38648755
Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in mice., PMID:38620028
Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy., PMID:38588830
Rare copy number variation in autoimmune Addison's disease., PMID:38562931
Identification of differentially expressed autophagy-related genes in cases of intracranial aneurysm: Bioinformatics analysis., PMID:38521147
For research use only. Not for human or drug use.
