Catalog No.
EHJ93202
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Val105-Thr433
Predicted molecular weight
39.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P01871
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Immunoglobulin heavy constant mu, Ig mu chain C region, Ig mu chain C region BOT, Ig mu chain C region GAL, Ig mu chain C region OU, IGHM
Rheumatoid Factor: Diagnostic and Prognostic Performance and Therapeutic Implications in Rheumatoid Arthritis., PMID:40094988
Comparative analysis of clinical profile, therapeutic management, and clinical prognosis of patients with seropositive or seronegative rheumatoid arthritis following the introduction of a first targeted therapy in a real-life setting., PMID:40063232
Impact of FcRn antagonism on vaccine-induced protective immune responses against viral challenge in COVID-19 and influenza mouse vaccination models., PMID:40028815
Rheumatoid factors revisited in the age of biologic therapy., PMID:39982406
Effects of efgartigimod treatment on humoral and cellular immune responses: analysis of T-cell-dependent antibody response in cynomolgus monkeys., PMID:39945037
What is rheumatoid factor? From screening to personalized management., PMID:39792161
Modification of Fc-fusion protein structures to enhance efficacy of cancer vaccine in plant expression system., PMID:39724301
Characteristics of the IgM repertoires in the peripheral blood of early rheumatoid arthritis patients., PMID:39446383
The evolution of flexibility and function in the Fc domains of IgM, IgY, and IgE., PMID:39445016
Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities., PMID:38779671
Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity-a potential diagnostic pitfall in patients with MOG-EM/MOGAD., PMID:38609667
The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function., PMID:37989996
Crystal structures of the human IgD Fab reveal insights into CH1 domain diversity., PMID:37267832
Structural basis for Fc receptor recognition of immunoglobulin M., PMID:37095205
Rheumatoid factor autoantibody repertoire profiling reveals distinct binding epitopes in health and autoimmunity., PMID:37055152
The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function., PMID:37034677
Randomized Phase 2 Trial of Telitacicept in Patients With IgA Nephropathy With Persistent Proteinuria., PMID:36938094
Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice., PMID:36702124
Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer., PMID:36274064
Tumour necrosis factor plays a deleterious role in the pathogenesis of chikungunya virus infection., PMID:36164989
Effect of glioma-derived immunoglobulin on biological function of glioma cells., PMID:36096041
The Chicken A and E Blood Systems Arise from Genetic Variation in and around the Regulators of Complement Activation Region., PMID:35977798
Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 Infection., PMID:35711449
Altered abundances of human immunoglobulin M and immunoglobulin G subclasses in Alzheimer's disease frontal cortex., PMID:35484384
The eIg technology to generate Ig-like bispecific antibodies., PMID:35427197
Regulatory Role of Fc Receptor in mIgM+ B Lymphocyte Phagocytosis in Flounder (Paralichthys olivaceus)., PMID:34975918
3D Structures of IgA, IgM, and Components., PMID:34884580
Development of anti-human IgM nanobodies as universal reagents for general immunodiagnostics., PMID:33984500
Effect of Anti-Rheumatic Treatment on the Periodontal Condition of Rheumatoid Arthritis Patients., PMID:33806304
Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines., PMID:33383098
Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases., PMID:33342002
Expression of Colorectal Cancer Antigenic Protein Fused to IgM Fc in Chinese Cabbage (Brassica rapa)., PMID:33143243
Generation of oligomers of subunit vaccine candidate glycoprotein D of Herpes Simplex Virus-2 expressed in fusion with IgM Fc domain(s) in Escherichia coli: A strategy to enhance the immunogenicity of the antigen., PMID:33047090
Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing., PMID:32983170
An in vitro refolding method to produce oligomers of anti-CHIKV, E2-IgM Fc fusion subunit vaccine candidates expressed in E. coli., PMID:32971119
Targeting FcRn for immunomodulation: Benefits, risks, and practical considerations., PMID:32896308
Global variability of the human IgG glycome., PMID:32788422
Electrochemical biosensor for the simultaneous determination of rheumatoid factor and anti-cyclic citrullinated peptide antibodies in human serum., PMID:32458832
D-mannose-specific Immunoglobulin M in Grass Puffer (Takifugu niphobles), a Nonhost Fish of a Monogenean Ectoparasite Heterobothrium okamotoi, Can Act as a Trigger for its Parasitism., PMID:32294759
Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial., PMID:32236404
Low FCMR mRNA expression in leukocytes of patients with Kawasaki disease six months after disease onset., PMID:32073687
Structural insights into immunoglobulin M., PMID:32029689
Native versus deglycosylated IgM in anti-MAG neuropathy: Correlation with clinical status - Study of 10 cases., PMID:31756640
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Atacicept in a Randomized Trial in Healthy Caucasian and Japanese Subjects., PMID:31529406
Mapping of the binding site for FcμR in human IgM-Fc., PMID:31449905
Staphylococcus pseudintermedius Sbi paralogs inhibit complement and bind IgM, IgG Fc and Fab., PMID:31335868
Immunoglobulin G structure and rheumatoid factor epitopes., PMID:31199818
Antibody modified gold nanoparticles for fast colorimetric screening of rheumatoid arthritis., PMID:31070614
Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones., PMID:30988351
Identification and Characterization of Novel Fc-Binding Heptapeptides from Experiments and Simulations., PMID:30960703
For research use only. Not for human or drug use.
