Catalog No.
EHJ93101
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu99-Lys327
Predicted molecular weight
27.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P01861
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Immunoglobulin heavy constant gamma 4,Ig gamma-4 chain C region
Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation., PMID:40506471
A robust label-free workflow for the immunoglobulin G subclass site-specific N-glycopeptides and the glycosylation of IgG 2 correlated with colorectal cancer., PMID:40466447
Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies., PMID:40464120
Glycosylation of Structured Protein Domains in Cell-Free Reaction Environments., PMID:40437661
Impact of Vaccine-Elicited Anti-Spike IgG4 Antibodies on Fc-Effector Functions Against SARS-CoV-2., PMID:40431678
Altered IgG N-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab N-Glycans., PMID:40427033
Balancing Reactivity and Specificity: Fc-Binding O-Acyl Hydroxamate Reagents for Site-Selective Antibody Labeling at Lys248., PMID:40423997
Fate of Stressed Oligoclonal Antibodies Tracked by Fluorescence Cross-Correlation Spectroscopy: IgG Aggregation Proceeds across the Species Barrier., PMID:40408563
Antibody Labeling With FITC Facilitates Controlled Release From Peptide Hydrogels Bearing Fc-Binding Motifs., PMID:40400208
Molecular determinants of sialylated IgG anti-inflammatory activity., PMID:40377989
Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy., PMID:40373007
Leveraging neonatal Fc receptor (FcRn) to enhance antibody transport across the blood brain barrier., PMID:40319060
Comprehensive Characterization of IgG2 Disulfide Isoforms Using Native Cation Exchange Chromatography-Mass Spectrometry and Peptide Mapping., PMID:40273039
The contemporary management of haemolytic disease of the fetus and newborn., PMID:40263127
Spatial and Sequential Topological Analysis of Molecular Dynamics Simulations of IgG1 Fc Domains., PMID:40261915
RNA production of IgG receptors is present in podocytes and varies depending on glycemia - preliminary results on Fc gamma receptor presence in kidney cells., PMID:40228757
Serum Disease-Specific IgG Fc Glycosylation as Potential Biomarkers for Nonproliferative and Proliferative Diabetic Retinopathy Using Mass Spectrometry., PMID:40204274
Neonatal Fc receptor participates in endocytosis of Fc fusion protein in vivo and in vitro., PMID:40187220
Plant-derived recombinant macromolecular PAP-IgG Fc as a novel prostate cancer vaccine candidate eliciting robust immune responses., PMID:40140219
Prediction of human pharmacokinetics of Fc-engineered therapeutic monoclonal antibodies using human FcRn transgenic mice., PMID:40133232
Addition of a short HIV-1 fusion-inhibitory peptide to PRO 140 antibody dramatically increases its antiviral breadth and potency., PMID:40130879
Effectiveness and safety of asfotase alfa for people with hypophosphatasia: a plain language summary of three studies., PMID:40110697
Novel, fully human, anti-PfCSP antibodies with potent antimalarial activity using a phage display based strategy., PMID:40101454
Drug-Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice., PMID:40097766
An Enhanced Bimetallic Optical Fiber SPR Biosensor Using Graphene Oxide for the Label-Free and Sensitive Detection of Human IgG., PMID:40096495
Engineering and Structural Elucidation of a Sac7d-Derived IgG Fc-Specific Affitin and Its Application for the Light-Controlled Affinity Purification of Antibodies., PMID:40085144
Impact of FcRn antagonism on vaccine-induced protective immune responses against viral challenge in COVID-19 and influenza mouse vaccination models., PMID:40028815
CHO-S expression of a novel human recombinant IgG1 of anti-ALD antibody isolated by phage mutation display., PMID:40015444
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant., PMID:40009690
Utility of binding protein fusions to immunoglobulin heavy chain constant regions from mammalian and avian species., PMID:39971160
Cell-based glycoengineering for production of homogeneous and specific glycoform-enriched antibodies with improved effector functions., PMID:39969996
Effects of efgartigimod treatment on humoral and cellular immune responses: analysis of T-cell-dependent antibody response in cynomolgus monkeys., PMID:39945037
Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties., PMID:39936406
Targeted cancer treatment using a novel EGFR-specific Fc-fusion peptide based on GE11 peptide., PMID:39934226
Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain., PMID:39870199
Engineered protein G variants for multifunctional antibody-based assemblies., PMID:39865354
A humanized anti-b7h3×4-1BB bispecific antibody exerts potent antitumour effects through the activation of innate and adaptive immunity., PMID:39847994
An engineered palivizumab IgG2 subclass for synthetic gp130 and fas-mediated signaling., PMID:39828098
A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity., PMID:39806351
Revolutionizing Heart Failure Therapy: Harnessing IVT mRNA and Fusion Protein Technology to Prolong rhBNP Half-Life., PMID:39806211
Establishment of Time-Resolved Fluorescence Immunoassay for Thyrotropin Receptor Antibodies and Clinical Application., PMID:39776097
Branched Linkers for Homogeneous Antibody-Drug Conjugates: How Long Is Long Enough?, PMID:39769122
Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria., PMID:39747065
Identification of the linear Fc-binding epitope on the bovine IgG1 Fc receptor of (boFcγRI) using synthetic peptides., PMID:39746504
A Novel, Site-Specific N-Linked Glycosylation Model Provides Mechanistic Insights Into the Process-Condition Dependent Distinct Fab and Fc Glycosylation of an IgG1 Monoclonal Antibody Produced by CHO VRC01 Cells., PMID:39740206
CLEC7A Knockdown Alleviates Ischemic Stroke by Inhibiting Pyroptosis and Microglia Activation., PMID:39735961
Modification of Fc-fusion protein structures to enhance efficacy of cancer vaccine in plant expression system., PMID:39724301
A multivalent binding model infers antibody Fc species from systems serology., PMID:39715286
Clinical efficacy of efgartigimod combined with intravenous methylprednisolone in the acute phase of neuromyelitis optica spectrum disorders., PMID:39709432
Fc mutagenesis enhances the functionality of anti-RhD monoclonal antibodies., PMID:39705537
For research use only. Not for human or drug use.
