Anti-AICDA Polyclonal Antibody

Catalog No.

PHJ53601

Species reactivity

Human, Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AICDA (Gly23-Leu183).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Single-stranded DNA cytosine deaminase,AICDA,Activation-induced cytidine deaminase,AID,Cytidine aminohydrolase

Purification

Purified by antigen affinity column.

Accession

Q9GZX7

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

The role of tungsten in modulating DNA double-strand break repair and class switch recombination., PMID:40360058

Unravelling the Impact of Outer Membrane Protein, OmpA, From S. Typhimurium on Aberrant AID Expression and IgM to IgA Class Switching in Human B-Cells., PMID:40300848

In vitro deamination assay to measure the activity and processivity of AID/APOBEC enzymes., PMID:40250961

16S rRNA and transcriptome analysis revealed the regulatory mechanism of Romboutsia lituseburensis on serum immunoglobulin levels in geese., PMID:40086254

Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II., PMID:40049162

Assessing human B cell responses to influenza virus vaccines and adjuvants in a PBMC-derived in vitro culture system., PMID:39616951

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity., PMID:39490533

Imatinib mesylate reduces c-MYC expression in double-hit lymphoma cells by suppressing inducible cytidine deaminase., PMID:39299959

Unfolding the symbiosis of AID, chromatin remodelers, and epigenetics-The ACE phenomenon of antibody diversity., PMID:39128629

Increased AID results in mutations at the CRLF2 locus implicated in Latin American ALL health disparities., PMID:39068148

Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation., PMID:39048716

RNA 2'-O-methylation promotes persistent R-loop formation and AID-mediated IgH class switch recombination., PMID:38977974

Interpretable deep learning reveals the role of an E-box motif in suppressing somatic hypermutation of AGCT motifs within human immunoglobulin variable regions., PMID:38863710

Clinical features and lymphocyte immunophenotyping analysis in primary immunodeficiency patients with non-transplant lymphoproliferative disorders., PMID:38838929

Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency., PMID:38803492

Taming AID mutator activity in somatic hypermutation., PMID:38614818

Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions., PMID:38605225

A Novel Heterozygous Variant in AICDA Impairs Ig Class Switching and Somatic Hypermutation in Human B Cells and is Associated with Autosomal Dominant HIGM2 Syndrome., PMID:38363477

Studying the cellular basis of small bowel enteropathy using high-parameter flow cytometry in mouse models of primary antibody deficiency., PMID:38352330

Modular cytosine base editing promotes epigenomic and genomic modifications., PMID:37994786

Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells., PMID:37949972

Activation-induced deaminase expression defines mature B cell lymphoma in the mouse., PMID:37809061

Borrelia burgdorferi Infection-Induced Persistent IgM Secretion Controls Bacteremia, but Not Bacterial Dissemination or Tissue Burden., PMID:37782044

Late-Onset Lymphopenia and ITP in a Patient with Hyper IgM Syndrome Due to a Homozygous Variant in AICDA., PMID:37402930

Subclonal TP53 mutations are frequent and predict resistance to radioimmunotherapy in follicular lymphoma., PMID:37379264

B cell-specific knockout of AID protects against atherosclerosis., PMID:37253865

[Activation-induced cytidine deaminase (AID) involved in the regulation of B cell immune senescence]., PMID:37248842

Optimal AID expression and efficient immunoglobulin class switch recombination are dependent on the hypoxia-inducible factor., PMID:37143384

Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification., PMID:37086201

Potential Pathogenic Impact of Cow's Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma., PMID:37047075

Type 2 hyper-IgM syndrome with a rare variant of AICDA gene mutation in a young woman., PMID:36931691

Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish., PMID:36575514

Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues., PMID:36569890

Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response., PMID:36456685

A Novel Organized Nasopharynx-Associated Lymphoid Tissue in Teleosts That Expresses Molecular Markers Characteristic of Mammalian Germinal Centers., PMID:36426979

MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses., PMID:36223741

Germline IgM predicts T cell immunity to Pneumocystis., PMID:35917185

Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells., PMID:35856618

IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans., PMID:35587276

Distinct disease-specific Tfh cell populations in 2 different fibrotic diseases: IgG4-related disease and Kimura disease., PMID:35568079

Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops., PMID:35524550

The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia., PMID:35358998

USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID., PMID:34983926

HomA and HomB, outer membrane proteins of Helicobacter pylori down-regulate activation-induced cytidine deaminase (AID) and Ig switch germline transcription and thereby affect class switch recombination (CSR) of Ig genes in human B-cells., PMID:34959071

The optimal pH of AID is skewed from that of its catalytic pocket by DNA-binding residues and surface charge., PMID:34870314

Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences., PMID:34862258

Single-cell atlas of splenocytes reveals a critical role of a novel plasma cell‒specific marker Hspa13 in antibody class-switching recombination and somatic hypermutation., PMID:34837777

UnAIDed Class Switching in Activated B-Cells Reveals Intrinsic Features of a Self-Cleaving IgH Locus., PMID:34777346

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis., PMID:34762705

Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria., PMID:34693907

Document Download

Anti-AICDA Polyclonal Antibody.pdf