Catalog No.
YHN21701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala28-Ala1262
Predicted molecular weight
139.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UHC6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Contactin-associated protein-like 2, Cell recognition molecule Caspr2, CNTNAP2, CASPR2, KIAA0868
A hierarchy of PDZ domain scaffolding proteins clusters the Kv1 K+ channel protein complex at the axon initial segment., PMID:40408471
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II): Antibodies to Surface Antigens., PMID:40393020
Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study., PMID:40303411
Neurodegeneration and the immune system: lessons from autoimmune encephalitis., PMID:40274643
Successful treatment of morvan syndrome with efgartigimod: report of two cases., PMID:40268813
From immunobiology to intervention: Pathophysiology of autoimmune encephalitis., PMID:40267699
Age-Dependent Effects of Loss of Contactin-Associated Protein-Like 2, an Autism-Associated Gene, on the Acquisition and Recall of Fear Memory., PMID:40247148
Permissive central tolerance plus defective peripheral checkpoints license pathogenic memory B cells in CASPR2-antibody encephalitis., PMID:40238887
Leucine-rich glioma-inactivated protein 1 antibody-positive limbic encephalitis in a patient with an early-stage asymptomatic breast cancer., PMID:40180343
Case Report: CASPR2-associated autoimmune encephalitis with NF155 Antibody-positive autoimmune nodopathies: a rare case with hyponatremia onset., PMID:40160818
Intravenous immunoglobulin as first-line acute treatment in adults with autoimmune encephalitis caused by antibodies to NMDAR, LGI1 and CASPR2., PMID:40131535
Retrograde Amnesia in LGI1 and CASPR2 Limbic Encephalitis: Two Case Reports and a Systematic Literature Review., PMID:40116573
Activated αβ T- and reduced mucosa-associated invariant T cells in LGI1- and CASPR2-encephalitis., PMID:40094812
Prevalence, clinical profiles, and prognosis of Isaacs syndrome: A nationwide survey study in Japan., PMID:40058033
Capturing what matters: Patient-reported LGI1-ANTibody encephalitis outcome RatiNg scale (LANTERN)., PMID:39996410
GAD antibodies in neurological disease: a critical evaluation of the utility and treatment implications of GAD antibodies in clinical practice., PMID:39985693
Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model., PMID:39984138
Enigmatic intractable Epilepsy patients have antibodies that bind glutamate receptor peptides, kill neurons, damage the brain, and cause Generalized Tonic Clonic Seizures., PMID:39932550
Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity., PMID:39896527
Hippocampal dysfunction after autoimmune encephalitis depending on the antibody type., PMID:39891731
A Rare Case of Anti-Caspr2 Autoimmune Encephalitis Associated with a Testicular Mixed Germ Cell Tumor., PMID:39839164
Immunotherapy-Resistant Neuropathic Pain and Fatigue Predict Quality-of-Life in Contactin-Associated Protein-Like 2 Antibody Disease., PMID:39825737
Recent advances in autoimmune encephalitis., PMID:39706227
CASPR2-related epilepsy: A distinctive and unrecognized form of epilepsy in adult and elderly males., PMID:39688843
Case report: Recurring potassium channel complex autoimmunity-related neuropathic pain., PMID:39524448
Histiocytic necrotizing lymphadenitis with autoimmune encephalitis in a child: a case report., PMID:39524397
Kidney injury: An overlooked manifestation in autoimmune encephalitis., PMID:39486221
Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance., PMID:39467237
A case series: Three cases of Morvan's syndrome as a rare autoimmune disorder with anti-Caspr2 antibody., PMID:39432629
Isaacs' syndrome: Clinical and paraclinical perspectives in a series of cases., PMID:39431227
Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes., PMID:39393351
C9orf72 Gene-Associated Frontotemporal Dementia Mimicking Autoimmune Pathology., PMID:39382125
Uncommon Pediatric Immune-Mediated Epilepsy: Disease Course, Diagnosis, and Outcome - A Series of Three Cases., PMID:39377237
MRI findings in autoimmune encephalitis., PMID:39358087
The neurobiology and immunology of CASPR2-associated neurological disorders., PMID:39341757
The cause of nodding syndrome remains unknown - Authors' reply., PMID:39341216
Multiple system atrophy mimics CASPR2 antibody-associated disease: a case report., PMID:39319563
Clinical characteristics and outcomes of patients with antibody-related autoimmune encephalitis presenting with disorders of consciousness: A prospective cohort study., PMID:39315845
Post-Coronavirus Disease Autoimmunity-associated Morvan's Syndrome., PMID:39291533
IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study., PMID:39270144
B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity., PMID:39222408
Clinical characteristics and long-term outcome of CASPR2 antibody-associated autoimmune encephalitis in children., PMID:39183357
Neuromyotonia., PMID:39174249
Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models., PMID:39142424
Autoimmune Encephalitis., PMID:39088286
HLA and KIR genetic association and NK cells in anti-NMDAR encephalitis., PMID:39050850
Morvan's syndrome with hypercoagulable condition in a patient positive for anti-CASPR2 antibodies: A case report., PMID:39029039
Anti-contact protein-associated protein 2 antibody encephalitis in children: A case report., PMID:39015900
Distinct plasma metabolomic signatures differentiate autoimmune encephalitis from drug-resistant epilepsy., PMID:39012808
Morvan Fibrillary Chorea Associated with Monoclonal B Cell Lymphocytosis., PMID:38963810
For research use only. Not for human or drug use.
