Catalog No.
YMJ41101
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser715-Trp1033
Predicted molecular weight
37.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8R4B8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NACHT, LRR and PYD domains-containing protein 3, 3.6.4.-, Cold autoinflammatory syndrome 1 protein homolog, Cryopyrin, Mast cell maturation-associated-inducible protein 1, PYRIN-containing APAF1-like protein 1, Nlrp3, Cias1, Mmig1, Nalp3, Pypaf1
Single cell analysis and bioinformatics reveal pyroptosis mechanisms in hepatocellular carcinoma., PMID:40516009
SELEX (Systematic Evolution of Ligands by Exponential Enrichment) to Identify DNA Motifs Mirroring Chromosome Targets of the Hypothetical Transcription Factor NLRP3., PMID:40515928
Reduced NF-κB/NLRP3/IL-18 signaling increases the protective effect of L-glutamine against LPS-induced retinal inflammation in mice: Utilization of network pharmacology and experimental validation., PMID:40513937
Dahuang Huanglian Decoction alleviates dysbiosis by inhibiting GBP5/NLRP3 signaling pathway-mediated pyroptosis of colonic epithelial cells., PMID:40513920
Corydalis yanhusuo Polysaccharides regulates HPA-axis mediated microglia activation and inhibits astrocyte A1 transformation to improve depression-like behavior., PMID:40513699
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis., PMID:40512290
Activation of pyroptosis impairs basal cell differentiation in the nasal epithelium in chronic rhinosinusitis with nasal polyps., PMID:40511559
MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection., PMID:40510795
Anxiolytic Effects of Cichorium intybus L. Oligo-Polysaccharides by Modulating Gut Microbiota, Neuronal Signaling Pathways, and Neuroinflammation in Chronic Sleep Deprivation-Stressed Mice., PMID:40509387
Anti-Inflammatory Potential of Essential Oil from the Heart-Wood of the Folk Medicinal Tree Cinnamomum kanehirai Hayata in Macrophages., PMID:40508226
Bridging Pancreatic Amyloidosis and Neurodegeneration: The Emerging Role of Amylin in Diabetic Dementia., PMID:40507832
Cinnamomum cassia Alleviates Neuropsychiatric Lupus in a Murine Experimental Model., PMID:40507090
Cerebral Hemorrhage-Related Inflammatory Response Mediated by NINJ1 and the Protective Effects of Atorvastatin., PMID:40503750
Combating multiple aetiologies of Alzheimer's disease to rescue behavioural deficits., PMID:40502821
Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage., PMID:40502390
OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis., PMID:40500776
Copper exposure elicits pyroptosis and inflammation in bursa of Fabricius and omega-3 reverses this phenomenon by inhibiting NF-κB-NLRP3-GSDMD axis: In vivo, in vitro, and in silico investigations., PMID:40500068
Spectosis: Dying for a complement., PMID:40499516
mTOR Modulates NLRP3 Inflammasome Activation via Nuclear Translocation and STAT1 Inhibition., PMID:40498369
Porphyromonas gingivalis-Lipopolysaccharide Induced Caspase-4 Dependent Noncanonical Inflammasome Activation Drives Alzheimer's Disease Pathologies., PMID:40497980
HIV-1 Tat mediates microglial NLRP3 inflammasome activation and neurotoxicity by inducing cytosolic mtDNA stress., PMID:40494474
Dietary procyanidin B1 attenuates fibrogenesis and inflammation in hepatic fibrosis: research on the possible health benefits of procyanidin B1., PMID:40493038
Identification of Grb2 protein as a potential mediator of macrophage activation in acute pancreatitis based on bioinformatics and experimental verification., PMID:40491924
LncRNA MIR503HG regulates NETs-mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ., PMID:40490947
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer's Disease., PMID:40490662
Cornus officinalis loganin attenuates acute lung injury in mice via regulating the PI3K/AKT/NLRP3 axis., PMID:40490233
Inflammation-associated lipidomic signatures prior to carotid artery atherosclerosis in people living with HIV., PMID:40489338
Rutin Protects Myocardial Ischemia-Reperfusion Injury via the NF-κB/NLRP3/Pyroptosis Pathway., PMID:40488073
Polysaccharide nanoparticles as potential immune adjuvants: Mechanism and function., PMID:40486863
Macrophage pyroptosis mediates hyperoxia-induced inflammatory lung injury in neonates., PMID:40486518
Inhibiting NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis: A New Role of GADD45B's Role in Hypertriglyceridemia-Induced Acute Pancreatitis., PMID:40485526
Metabolic dysregulation and temporal dynamics of NF-κB-p65/NLRP3, TXNIP, endoplasmic reticulum and mitochondrial stress in silica-induced pulmonary fibrosis in rats., PMID:40483952
NLRP3 activation promotes cGAS/STING signaling and antitumor immunity by colorectal cancer cells., PMID:40481953
Role of Macrophage TLR4 Expression in the Immunopathogenesis of Severe Aplastic Anemia., PMID:40481763
GPR56 function as a key repressor in hepatocyte pyroptosis and the pathogenesis of liver fibrosis., PMID:40481471
High-fat diet induces pre-eclampsia through dampening cell-autonomous C3 in trophoblasts., PMID:40481230
Thioredoxin-interacting protein: an emerging target for Alzheimer's disease., PMID:40480363
Late gestation heat stress induces inflammation and impacts nutrient transfer signature in the placenta of dairy cows., PMID:40480157
Resveratrol reduces the activation of NLRP3 inflammasomes in rheumatoid arthritis through SIRT1 and ITGB α5β1, especially in patients with high expression of ACPA., PMID:40480022
Discovery and structure-activity relationship studies of 3-pyridazinesulfonyl derivatives as a new class of inhibitors against NLRP3 inflammasome-dependent pyroptosis., PMID:40479892
Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway., PMID:40478791
Food additive β-caryophyllene mitigates alcoholic steatohepatitis by dual modulation of inflammation and lipid metabolism: a diet-based intervention strategy., PMID:40478217
Vanillin alleviates oxidative stress-mediated neuronal pyroptosis induced in rats by isoproterenol via SIRT1/NOX4/ROS/TXNIP/NLRP3 signaling pathway., PMID:40478189
Exploring the Role of NLRP3 in Neurodegeneration: Cutting-Edge Therapeutic Strategies and Inhibitors., PMID:40476303
The role of NLRP3 inflammasome in necrotizing enterocolitis., PMID:40473807
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis., PMID:40473047
Chronic ozone exposure induces hippocampal microglia activation by microbial dysbiosis in rat lungs., PMID:40472699
PGK1 phosphorylates NLRP3 and mediates inflammasome activation independent of its glycolytic activity., PMID:40471786
Luteolin Ameliorates Allergic Rhinitis in Mice through Modulating T Cell Subset Imbalance, Endoplasmic Reticulum Stress, and NLRP3 Inflammasome Axes., PMID:40471643
Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model., PMID:40469974
For research use only. Not for human or drug use.
