Catalog No.
VMH72401
Species reactivity
Mouse
Host species
Mouse
Isotype
IgG
Clonality
Monoclonal
Target
Bispecific, T-cell immunoreceptor with Ig and ITIM domains, V-set and transmembrane domain-containing protein 3, Tigit, Vstm3, Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, CD274, Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P86176 & Q9EP73
Applications
FuncS
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0247
Role of CD28+ PD-1+ Tc cells in immune response and prognosis prediction in hepatocellular carcinoma., PMID:40534863
TIGIT blockade improves anti-Mycobacterium tuberculosis immunity., PMID:40526725
Single-cell dissection of prognostic architecture and immunotherap response in Helicobacter pylori infection-associated gastric cancer., PMID:40525824
IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis., PMID:40524016
Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human., PMID:40518289
Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum., PMID:40509548
SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications., PMID:40500484
The dual role of TIGIT in regulatory and effector T cells in chronic liver disease., PMID:40496440
Imbalanced NK cell subpopulations and TIGIT expression limit cetuximab efficacy in colorectal cancer: A promising target for treatment enhancement., PMID:40490938
Semisynthesis of Novel Alicyclic Triterpene-Triazole Derivatives from Boswellia sacra Gum Resin: Potential Anti-breast Cancer and Immunomodulatory Effects on T‑Cell Activation., PMID:40488047
Enhanced anti-tumor activity by zinc finger repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs., PMID:40487483
Heterogeneous characteristics of γδ T cells in peripheral blood of diffuse large B-cell lymphoma., PMID:40483533
Preproinsulin-specific regulatory T cell-derived exosomes loaded with immune-checkpoint ligands can suppress autoimmune responses in type 1 diabetes., PMID:40482450
Expression of PSMD14 in lung adenocarcinoma and its impact on immune cell infiltration and prognosis: a comprehensive analysis based on RNA and single-cell RNA sequencing., PMID:40475775
TIM3 and TIGIT-expressing CD4 T cells are impacted by kidney transplantation and associated with risk of infection., PMID:40475763
Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1., PMID:40473838
Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407
Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment., PMID:40463500
Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy., PMID:40457441
Therapeutic B cell depletion identifies immunoregulatory networks., PMID:40454471
TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma., PMID:40448175
Impact of innate lymphoid cell type 2 in chronic lymphocytic leukemia on the function of treg and CD8+ T cells through IL-9., PMID:40445384
Correlation of serum Helios, CD226, TIGIT, and Foxp3 with tear film osmotic pressure and dry eye disease in patients with rheumatoid arthritis., PMID:40442984
Increased levels of Foxp3+CD4+NKT-like cells are associated with HIV disease progression., PMID:40441400
CD49a+ NK cells promote esophageal cancer development by inducing MDCSs infiltration via GM-CSF., PMID:40437020
Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing., PMID:40433374
Investigation of TIGIT, PVRIG, CD112 and CD155 expression in early and late onset preeclampsia., PMID:40425968
Desmocollin-3 and Bladder Cancer., PMID:40422563
Distinct immunity dynamics of natural killer cells in mild and moderate COVID-19 cases during the Omicron variant phase., PMID:40421029
NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells., PMID:40421025
Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes., PMID:40421022
Unravelling T cell exhaustion through co-inhibitory receptors and its transformative role in cancer immunotherapy., PMID:40415479
Adjuvant Immunotherapy in Microsatellite Instability-High Colon Cancer: A Literature Review on Efficacy, Challenges, and Future Directions., PMID:40415356
AdvanTIG-202: Phase 2 open-label, two-cohort multicenter study of ociperlimab plus tislelizumab and tislelizumab alone in patients with previously treated recurrent or metastatic cervical cancer., PMID:40411966
TIGIT antibody with PVR competitive ability enhances cancer immunotherapy and capable of eliciting anti-tumour immune memory., PMID:40394151
NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors., PMID:40392373
Beyond Canonical Immune Checkpoints: Overexpression of TNFRSF Members 4-1BB and OX-40 Marks T Cells Exhibiting Phenotypic Features of Exhaustion in Cervical Carcinoma., PMID:40387515
scRNA-seq reveals chemotherapy-induced tumor microenvironment changes in pancreatic ductal adenocarcinoma., PMID:40386264
Altered CD27-related T cell subsets reflect immune imbalance in systemic lupus erythematosus., PMID:40381105
Immune checkpoint inhibitors and immunosuppressive tumor microenvironment: current challenges and strategies to overcome resistance., PMID:40376861
Unlocking the potential of TIGIT in enhancing therapeutic strategies for acute myeloid leukemia through combined azacitidine therapy., PMID:40374899
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis., PMID:40374622
ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non-small cell lung cancer., PMID:40371640
Effects of pregnancy on breast cancer immunology: immune biomarker and TIL quantification., PMID:40368889
The role of epidermal growth factor in mediating survival in mouse sepsis is dependent upon an intact adaptive immune system., PMID:40368370
Single-cell analysis reveals potential therapeutic markers of peripheral blood mononuclear cells from bladder cancer patients., PMID:40367012
Single-Cell RNA Sequencing Reveals Functional Exhaustion of T Cells in Oral Lichen Planus., PMID:40366262
New Therapeutic Targets TIGIT, LAG-3 and TIM-3 in the Treatment of Advanced, Non-Small-Cell Lung Cancer., PMID:40362333
TIGIT blockade increases efficacy of PD-1 blockade combined with radiation therapy in triple-negative breast cancer model., PMID:40360046
Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies., PMID:40358739
For research use only. Not for human or drug use.
