Catalog No.
YMD61401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser2901-Glu3106
Predicted molecular weight
24.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q60675
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Laminin subunit alpha-2, Laminin M chain, Laminin-12 subunit alpha, Laminin-2 subunit alpha, Laminin-4 subunit alpha, Merosin heavy chain, Lama2
Integrative multi-omics study identifies sex-specific molecular signatures and immune modulation in bladder cancer., PMID:40458476
A survey on mutation spectrum in Iranian patients with limb-girdle muscular dystrophies., PMID:40361203
Increased HSD11β1 Expression in Human Leiomyomatous Uteri: Implication for Enhanced Glucocorticoid Signaling., PMID:40290045
A Spectrum of Pathogenic Variants in the LAMA2 Gene in the Russian Federation., PMID:39941024
Changes in Gene Expression of the Extracellular Matrix in Patients with Full-Thickness Rotator Cuff Tears of Varying Sizes., PMID:39912080
Laminin-dystroglycan mediated ferroptosis in hemorrhagic shock and reperfusion induced-cognitive impairment through AMPK/Nrf2., PMID:39864758
Systemic inhibition of bone morphogenetic protein 1.3 as a possible treatment for laminin-related congenital muscular dystrophy., PMID:39621123
Downregulation of Genes for Skeletal Muscle Extracellular Matrix Components by Cisplatin., PMID:39522978
Structural and functional consequences of non-synonymous SNPs within the LAMA2 protein: a molecular dynamics perspective., PMID:39522170
Acute weakness and elevated creatine kinase levels associated with coxsackievirus infection in LAMA2-related muscular dystrophy., PMID:39515249
A 5-year natural history study in LAMA2-related muscular dystrophy and SELENON-related myopathy: the Extended LAST STRONG study., PMID:39443859
Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms., PMID:39379105
Noncoding variants are a rare cause of recessive developmental disorders in trans with coding variants., PMID:39243181
A Multicenter Cross-Sectional Study of the Swiss Cohort of LAMA2-Related Muscular Dystrophy., PMID:39213089
Cohort Expansion and Genotype-Phenotype Analysis of RAB11A-Associated Neurodevelopmental Disorder., PMID:39181022
An international retrospective early natural history study of LAMA2-related dystrophies., PMID:39177609
Cardiac Involvement in LAMA2-Related Muscular Dystrophy and SELENON-Related Congenital Myopathy: A Case Series., PMID:39177608
Single-Nucleus Landscape of Glial Cells and Neurons in Alzheimer's Disease., PMID:39153159
Cross-sectional survey study of the natural history of LAMA2-related dystrophy., PMID:39126899
Phenotype-genotype spectrum of a cohort of congenital muscular dystrophies: a single-centre experience from India., PMID:39103709
Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys., PMID:39060269
Extracellular Matrix Protein Signatures of the Outer and Inner Zones of the Rat Adrenal Cortex., PMID:39018382
Thrombospondin-4 deletion does not exacerbate muscular dystrophy in β-sarcoglycan-deficient and laminin α2 chain-deficient mice., PMID:38926599
Polymerizing laminins in development, health, and disease., PMID:38825010
Lama1 upregulation prolongs the lifespan of the dyH/dyH mouse model of LAMA2-related congenital muscular dystrophy., PMID:38777118
Genetic profile of Brazilian patients with LAMA2-related dystrophies., PMID:38747280
A novel deep intronic variant in LAMA2 identified by RNA sequencing., PMID:38691940
Laminin Alpha 2 Enhances the Protective Effect of Exosomes on Human iPSC-Derived Cardiomyocytes in an In Vitro Ischemia-Reoxygenation Model., PMID:38612582
Analysis of Vascular Smooth Muscle Cells from Thoracic Aortic Aneurysms Reveals DNA Damage and Cell Cycle Arrest as Hallmarks in Bicuspid Aortic Valve Patients., PMID:38594816
RNA-binding proteins potentially regulate the alternative splicing of apoptotic genes during knee osteoarthritis progression., PMID:38504181
European Joint Programme on Rare Diseases workshop: LAMA2-muscular dystrophy: paving the road to therapy March 17-19, 2023, Barcelona, Spain., PMID:38306718
Genetic blueprint of congenital muscular dystrophies with brain malformations in Egypt: A report of 11 families., PMID:38296890
Fatal Case of Exercise Collapse Associated with Sickle Cell Trait with Novel Underlying LAMA2 Mutation., PMID:38261548
Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development., PMID:38146640
A synonymous single nucleotide polymorphism (g.36417726C > A) in the Lama2 gene influencing fat deposition is associated with post-partum anestrus interval in Murrah buffalo., PMID:38008271
Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice., PMID:37974221
Myelin abnormalities in merosin-deficient congenital muscular dystrophy., PMID:37933889
Functional enrichment analysis of mutated genes in children with hyperthyroidism., PMID:37876543
Combined sequence and copy number analysis improves diagnosis of limb girdle and other myopathies., PMID:37688281
Autophagy increase in Merosin-Deficient Congenital Muscular Dystrophy type 1A., PMID:37522802
Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing to Schizophrenia and Major Depressive Disorder in Two Families., PMID:37511534
Congenital Muscular Dystrophy Due to Merosin Deficiency: Report of a New Mutation., PMID:37416022
Merosin-deficient congenital muscular dystrophy type 1a: detection of LAMA2 variants in Vietnamese patients., PMID:37388928
An atypical expression of core α-Dystroglycan and Laminin-α2 in skin fibroblasts of patients with congenital muscular dystrophies., PMID:37318662
A perfusion-based three-dimensional cell culture system to model alveolar rhabdomyosarcoma pathological features., PMID:37296184
Identification of New Key Genes and Their Association with Breast Cancer Occurrence and Poor Survival Using In Silico and In Vitro Methods., PMID:37238942
Brain MRI Abnormalities, Epilepsy and Intellectual Disability in LAMA2 Related Dystrophy - a Genotype/Phenotype Correlation., PMID:37182895
Rare Coding Variants in Patients with Non-Syndromic Vestibular Dysfunction., PMID:37107589
Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy., PMID:37038437
For research use only. Not for human or drug use.
