Catalog No.
YMN44901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Val25-Asn541
Predicted molecular weight
59.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23953
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Carboxylesterase 1C, 3.1.1.1, Liver carboxylesterase N, Lung surfactant convertase, PES-N, Ces1c, Es1
Brain Exposure to the Macrocyclic ALK Inhibitor Zotizalkib is Restricted by ABCB1, and Its Plasma Disposition is Affected by Mouse Carboxylesterase 1c., PMID:39312722
ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure., PMID:38733773
Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice., PMID:38423793
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency., PMID:38253384
Pharmacokinetics of the KRASG12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c., PMID:37586117
Assessment of metabolic activation of felbamate in chimeric mice with humanized liver in combination with in vitro metabolic assays., PMID:35786679
CRISPR-Cas9 editing of CAFFEOYL SHIKIMATE ESTERASE 1 and 2 shows their importance and partial redundancy in lignification in Populus tremula × P. alba., PMID:34160888
Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice., PMID:33900070
Influence of N-acetyltransferase 2 gene polymorphisms on the in vitro metabolism of the epidermal growth factor receptor inhibitor rociletinib., PMID:33818816
Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers., PMID:33788548
Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay., PMID:33478046
Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice., PMID:32027397
Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV., PMID:31924756
Pig liver esterases PLE1 and PLE6: heterologous expression, hydrolysis of common antibiotics and pharmacological consequences., PMID:31664043
Role of esterase mediated hydrolysis of simvastatin in human and rat blood and its impact on pharmacokinetic profiles of simvastatin and its active metabolite in rat., PMID:30776567
Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid., PMID:30685356
Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice., PMID:30093567
Transcriptomic and proteomic analysis of potential therapeutic target genes in the liver of metformin‑treated Sprague‑Dawley rats with type 2 diabetes mellitus., PMID:29512687
Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol., PMID:28427893
P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice., PMID:26317243
Aptamer-modified magnetic beads in affinity separation of proteins., PMID:25749947
P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice., PMID:24727322
Neural stem cell-mediated delivery of irinotecan-activating carboxylesterases to glioma: implications for clinical use., PMID:24167321
Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues., PMID:22984285
Enzyme-based logic: OR gate with double-sigmoid filter response., PMID:22804339
Promiscuous enantioselective (-)-γ-lactamase activity in the Pseudomonas fluorescens esterase I., PMID:22359066
Production of ES1 plasma carboxylesterase knockout mice for toxicity studies., PMID:21875074
Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein., PMID:21659478
Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2., PMID:21540359
Nongradient blue native gel analysis of serum proteins and in-gel detection of serum esterase activities., PMID:21237726
Mouse serum paraoxonase-1 lactonase activity is specific for medium-chain length fatty acid lactones., PMID:21044894
Non-lipolytic and lipolytic sequence-related carboxylesterases: a comparative study of the structure-function relationships of rabbit liver esterase 1 and bovine pancreatic bile-salt-activated lipase., PMID:20655391
A one-pot, simple methodology for cassette randomisation and recombination for focused directed evolution., PMID:18559369
Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry., PMID:15525694
In vitro degradation of insulin-loaded poly (n-butylcyanoacrylate) nanoparticles., PMID:15046928
Esterase-1: developmental expression in the mouse and distribution of related proteins in other species., PMID:1632635
Linkage of Nat and Es-1 in the mouse and development of strains congenic for N-acetyltransferase., PMID:3209851
cDNA cloning of esterase 1, the major esterase activity in mouse plasma., PMID:2895647
The 65-kDa phorbol-diester hydrolase in mouse plasma is esterase 1 and is immunologically distinct from the 56-kDa phorbol-diester hydrolase in mouse liver., PMID:3864781
Clofibrate-induced decrease in esterase 1 levels in the serum of the house mouse, Mus musculus., PMID:6870940
Purification and characterization of esterase 6A, a trimeric esterase of the house mouse (Mus musculus)., PMID:7160378
For research use only. Not for human or drug use.
