Catalog No.
YHN44501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro96-Cys282
Predicted molecular weight
23.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2D1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cyclic AMP-dependent transcription factor ATF-5, cAMP-dependent transcription factor ATF-5, Activating transcription factor 5, Transcription factor ATFx, ATF5, ATFX
Machine learning explores the prognostic and immuno-oncological impact of mitochondrial unfolded protein response in CESC., PMID:40410615
Identification of the hub genes involved in ATF5 mediated stress response in vitrified mouse oocytes based on WGCNA., PMID:40409046
Targeting ATF5, CEBPB, and CEBPD with Cell-Penetrating Dpep Sensitizes Tumor Cells to NK-92MI Cell Cytotoxicity., PMID:40358191
UPRmt alleviates bone cancer pain through the restoration of mitochondrial function., PMID:40273969
BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain., PMID:40230701
Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis., PMID:40222260
Growth differentiation factor 15: a valuable biomarker for the diagnosis and prognosis of late-onset form of multiple Acyl-CoA dehydrogenation deficiency., PMID:40181460
PM2.5 from automobile exhaust induces apoptosis in male rat germ cells via the ROS-UPRmt signaling pathway., PMID:40173155
Enhancing Sonodynamic Therapy in Prostate Cancer: Cavitation-Induced Cytotoxicity and Mitochondrial Unfolded Protein Response Disruption., PMID:40131613
Outer radial glia promotes white matter regeneration after neonatal brain injury., PMID:40023165
The c.119-123dup5bp mutation in human γC-crystallin destabilizes the protein and activates the unfolded protein response to cause highly variable cataracts., PMID:39994382
Fine-Tuning of ATF4 DNA Binding Activity by a Secondary Basic Motif Unique to the ATF-X Subfamily of bZip Transcription Factors., PMID:39993237
Inhibition of cytosolic translation mitigates mitochondrial dysfunction in C. elegans., PMID:39896682
Neuroprotective role of Da Qin Jiu decoction in ischemic stroke: Mitochondrial rescue through PI3K/Akt-mediated UPRmt activation., PMID:39894416
Exploiting Mitochondria by Triggering a Faulty Unfolded Protein Response Leads to Effective Cardioprotection., PMID:39744160
Trimethylamine-N-oxide accelerates osteoporosis by PERK activation of ATF5 unfolding., PMID:39719538
Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet., PMID:39683422
Nicotinamide riboside targets mitochondrial unfolded protein response to reduce alcohol-induced damage in Kupffer cells., PMID:39624887
Altered mitochondrial unfolded protein response and protein quality control promote oxidative distress in down syndrome brain., PMID:39586382
ATF5-mediated mitochondrial unfolded protein response protects against Pb-induced mitochondria damage in SH-SY5Y cell., PMID:39547369
METTL14 attenuates cancer stemness by suppressing ATF5/WDR74/β-catenin axis in gastric cancer., PMID:39497511
Acute contractile activity induces the activation of the mitochondrial integrated stress response and the transcription factor ATF4., PMID:39417830
Decreased ATF5 level contributes to improved mitochondrial function in oocytes exposed to vitrification stress., PMID:39372953
GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression., PMID:39283723
Transcriptional Dynamics and Key Regulators of Adipogenesis in Mouse Embryonic Stem Cells: Insights from Robust Rank Aggregation Analysis., PMID:39273102
Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response., PMID:39153513
DPEP Inhibits Cancer Cell Glucose Uptake, Glycolysis and Survival by Upregulating Tumor Suppressor TXNIP., PMID:38920655
ATF5-Mediated Mitochondrial Unfolded Protein Response (UPRmt) Protects Neurons Against Oxygen-Glucose Deprivation and Cerebral Ischemia., PMID:38913800
Engineered Exosomes with ATF5-Modified mRNA Loaded in Injectable Thermogels Alleviate Osteoarthritis by Targeting the Mitochondrial Unfolded Protein Response., PMID:38626424
ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor., PMID:38534416
AMPK Suppression Due to Obesity Drives Oocyte mtDNA Heteroplasmy via ATF5-POLG Axis., PMID:38499990
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy., PMID:38472656
D-2-HG Inhibits IDH1mut Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation., PMID:38445960
Dabrafenib Alters MDSC Differentiation and Function by Activation of GCN2., PMID:38421883
Baicalein ameliorated obesity-induced cardiac dysfunction by regulating the mitochondrial unfolded protein response through NRF2 signaling., PMID:38394729
Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice., PMID:38388750
CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis., PMID:38278820
Stress granules affect the dual PI3K/mTOR inhibitor response by regulating the mitochondrial unfolded protein response., PMID:38238825
NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations., PMID:38228611
ATF5 promotes malignant T cell survival through the PI3K/AKT/mTOR pathway in cutaneous T cell lymphoma., PMID:38223508
O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4., PMID:38192280
Activating Transcription Factor 5 Promotes Neuroblastoma Metastasis by Inducing Anoikis Resistance., PMID:38014922
Screening of an FDA-approved compound library identifies apigenin for the treatment of myocardial injury., PMID:37928261
ATF5-regulated Mitochondrial Unfolded Protein Response Attenuates Neuronal Damage in Epileptic Rat by Reducing Endoplasmic Reticulum Stress Through Mitochondrial ROS., PMID:37847329
Detection of lineage-reprogramming efficiency of tumor cells in a 3D-printed liver-on-a-chip model., PMID:37771785
MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response., PMID:37758822
mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway., PMID:37649699
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription., PMID:37460695
Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine., PMID:37415806
TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA., PMID:37286744
For research use only. Not for human or drug use.
