Catalog No.
EHN44101
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Cys22-Pro254
Predicted molecular weight
31.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IYV9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Izumo sperm-egg fusion protein 1, IZUMO1, Oocyte binding/fusion factor, Sperm-specific protein izumo, OBF
Immunolocalization and proteomic analyses of IZUMO1 in porcine spermatozoa., PMID:40469420
Updating the Role of JUNO and Factors Involved in Its Function during Fertilization., PMID:40168958
Noncanonical phagocytosis-like SEAL establishes mammalian fertilization., PMID:40138310
Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13., PMID:40042902
Sperm protein profile and their correlation with frozen semen quality of indigenous Indonesian buffalo bulls., PMID:40013273
Clinicopathological and in Silico Insights into Male Infertility: Agerelated Trends and Anti-sperm Antibodies Post COVID-19 Vaccination., PMID:39886784
Decoding the Genes Orchestrating Egg and Sperm Fusion Reactions and Their Roles in Fertility., PMID:39767756
Rat copper transport protein 2 (CTR2) is involved in fertilization through interaction with IZUMO1 and JUNO., PMID:39454481
A conserved fertilization complex bridges sperm and egg in vertebrates., PMID:39423812
Variation of sperm quality and circular RNA content in men exposed to environmental contamination with heavy metals in 'Land of Fires', Italy., PMID:38885964
Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse., PMID:38666763
Detection of Protein Biomarkers Relevant to Sperm Characteristics and Fertility in Semen in Three Wild Felidae: The Flat-Headed Cat (Prionailurus planiceps), Fishing Cat (Prionailurus viverrinus), and Asiatic Golden Cat (Catopuma temminckii)., PMID:38612267
Expression of IZUMO1 and JUNO in the gonads of domestic cats (Felis catus)., PMID:38484673
No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1., PMID:38381819
Positive selection in gamete interaction proteins in Carnivora., PMID:38318732
Sperm induction of somatic cell-cell fusion as a novel functional test., PMID:38265078
Implication of IZUMO2 in the cell-in-cell phenomenon: A potential therapeutic target for triple-negative breast cancer., PMID:38258402
RNA sequencing profiles reveals progressively reduced spermatogenesis with progression in adult cryptorchidism., PMID:38027210
IZUMO1 Receptor Localization during Hyaluronic Acid Selection in Human Spermatozoa., PMID:38001873
Molecular dynamics of JUNO-IZUMO1 complexation suggests biologically relevant mechanisms in fertilization., PMID:37990051
Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO., PMID:37951137
Juno and CD9 protein network organization in oolemma of mouse oocyte., PMID:37635875
The EGF-motif-containing protein SPE-36 is a secreted sperm protein required for fertilization in C. elegans., PMID:37453426
Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa., PMID:37151878
Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin., PMID:36972453
Causal associations and shared genetics between hypertension and COVID-19., PMID:36951353
1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction., PMID:36787362
Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?, PMID:36656648
Improvement of Fertilization Capacity and Developmental Ability of Vitrified Bovine Oocytes by JUNO mRNA Microinjection and Cholesterol-Loaded Methyl-β-Cyclodextrin Treatment., PMID:36614032
A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion., PMID:36394541
Changes in cortical endoplasmic reticulum clusters in the fertilized mouse oocyte†., PMID:36136741
SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins., PMID:36115925
MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization., PMID:36070373
The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding., PMID:36050562
C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly., PMID:35960805
Expression of membrane fusion proteins in spermatozoa and total fertilisation failure during in vitro fertilisation., PMID:35727923
Live imaging-based assay for visualising species-specific interactions in gamete adhesion molecules., PMID:35688940
In silico Docking Analysis for Blocking JUNO-IZUMO1 Interaction Identifies Two Small Molecules that Block in vitro Fertilization., PMID:35478965
The Role of Sperm Proteins IZUMO1 and TMEM95 in Mammalian Fertilization: A Systematic Review., PMID:35409288
Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish., PMID:35393517
High Resolution Proteomic Analysis of Subcellular Fractionated Boar Spermatozoa Provides Comprehensive Insights Into Perinuclear Theca-Residing Proteins., PMID:35252197
Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats., PMID:35096839
Effects of green tea polyphenols and α-tocopherol on the quality of chilled cat spermatozoa and sperm IZUMO1 protein expression during long-term preservation., PMID:35066238
Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction., PMID:34879103
The molecular underpinnings of fertility: Genetic approaches in Caenorhabditis elegans., PMID:34322672
The interaction between Tu-Izumo1 and Tu-JUNO is involved in turtles hybridization., PMID:34314375
Unraveling Subcellular and Ultrastructural Changes During Vitrification of Human Spermatozoa: Effect of a Mitochondria-Targeted Antioxidant and a Permeable Cryoprotectant., PMID:34277615
Oolemma Receptors in Mammalian Molecular Fertilization: Function and New Methods of Study., PMID:34095128
Immunolocalization of Fertilin β, IZUMO1, and P34H in Ram Spermatozoa., PMID:33956503
Evaluation of multi-epitope recombinant protein as a candidate for a contraceptive vaccine., PMID:33930667
For research use only. Not for human or drug use.
