Catalog No.
EHA82401
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Val150
Predicted molecular weight
45.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43924
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDE6D, Protein p17, GMP-PDE delta, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, PDED
An NTCP-mediated liver-targeting chimeras (NTLiverTac) design strategy and its application to hepatoblastoma models., PMID:40424783
Discovery of Potent PDEδ/NAMPT Dual Inhibitors: Preclinical Evaluation in KRAS Mutant Pancreatic Cancer Cells., PMID:40289347
Gaudichaudion H inhibits KRAS-mutant pancreatic cancer cell growth through interfering PDEδ-KRAS interaction., PMID:40288433
Metformin inhibits the progression of castration-resistant prostate cancer by regulating PDE6D induced purine metabolic alternation and cGMP / PKG pathway activation., PMID:40216151
An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth., PMID:38758695
Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies., PMID:37887031
Recurrent Implantation Failure: Bioinformatic Discovery of Biomarkers and Identification of Metabolic Subtypes., PMID:37686293
Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study., PMID:37605207
PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia., PMID:36672247
Multiple ciliary localization signals control INPP5E ciliary targeting., PMID:36063381
Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension., PMID:35506379
Validation of a small molecule inhibitor of PDE6D-RAS interaction with favorable anti-leukemic effects., PMID:35422065
Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling., PMID:35104933
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216., PMID:34965125
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane., PMID:34447983
The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L., PMID:33808286
Promotion of cancer cell stemness by Ras., PMID:33544116
NMR in integrated biophysical drug discovery for RAS: past, present, and future., PMID:32804298
Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding., PMID:32101165
The morbid genome of ciliopathies: an update., PMID:32055034
Diffuse or hitch a ride: how photoreceptor lipidated proteins get from here to there., PMID:31811799
Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa., PMID:31106594
The Delta Subunit of Rod-Specific Photoreceptor cGMP Phosphodiesterase (PDE6D) Contributes to Hepatocellular Carcinoma Progression., PMID:30901922
Chaperones and retinal disorders., PMID:30635087
Disruption of RPGR protein interaction network is the common feature of RPGR missense variations that cause XLRP., PMID:30622176
KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer., PMID:30594165
A novel PDE6D mutation in a patient with Joubert syndrome type 22 (JBTS22)., PMID:30423442
The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo., PMID:30382908
The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium., PMID:30228185
Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors., PMID:28929751
Mechanisms of mutant PDE6 proteins underlying retinal diseases., PMID:28583373
Prenylated retinal ciliopathy protein RPGR interacts with PDE6δ and regulates ciliary localization of Joubert syndrome-associated protein INPP5E., PMID:28172980
Shuttling and sorting lipid-modified cargo into the cilia., PMID:27911709
Sorting of lipidated cargo by the Arl2/Arl3 system., PMID:27806215
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner., PMID:27493202
A GDI/GDF-like system for sorting and shuttling ciliary proteins., PMID:27487321
Higher order signaling: ARL2 as regulator of both mitochondrial fusion and microtubule dynamics allows integration of 2 essential cell functions., PMID:27400436
The cilium: a cellular antenna with an influence on obesity risk., PMID:27323230
PDE6D binds to the C-terminus of RPGR in a prenylation-dependent manner., PMID:26553938
Membrane protein transport in photoreceptors: the function of PDEδ: the Proctor lecture., PMID:25550383
The EHEC-host interactome reveals novel targets for the translocated intimin receptor., PMID:25519916
Mistrafficking of prenylated proteins causes retinitis pigmentosa 2., PMID:25422369
Unc119 gene deletion partially rescues the GRK1 transport defect of Pde6d (- /-) cones., PMID:24664735
Prenylation defects in inherited retinal diseases., PMID:24401286
A homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium., PMID:24166846
Targeting the K-Ras/PDEδ protein-protein interaction: the solution for Ras-driven cancers or just another therapeutic mirage?, PMID:23939923
The interplay between RPGR, PDEδ and Arl2/3 regulate the ciliary targeting of farnesylated cargo., PMID:23559067
Identification of PDE6D as a molecular target of anecortave acetate via a methotrexate-anchored yeast three-hybrid screen., PMID:23301619
Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells., PMID:24683528
For research use only. Not for human or drug use.
