Catalog No.
EHA00501
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly20-Ser228
Predicted molecular weight
26.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A6ND01
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IZUMO1 receptor protein JUNO, JUNO, Sperm-egg fusion protein Juno, FOLR4, IZUMO1R, Folate receptor delta, FR-delta, Folate receptor 4
Updating the Role of JUNO and Factors Involved in Its Function during Fertilization., PMID:40168958
Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model., PMID:39589811
Participation of WD repeat-containing protein 54 (WDR54) in rat sperm-oocyte fusion through interaction with both IZUMO1 and JUNO., PMID:37951137
Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin., PMID:36972453
Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction., PMID:34879103
Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion., PMID:33871360
Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site†., PMID:33724343
Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice., PMID:32393636
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse., PMID:31672133
Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells., PMID:30837262
JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation., PMID:30517645
New Insights into the Molecular Events of Mammalian Fertilization., PMID:30170889
Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization., PMID:29243140
Novel insights into the molecular mechanism of sperm-egg fusion via IZUMO1., PMID:27995377
Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization., PMID:27416963
Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex., PMID:27309818
Structural biology: When sperm meets egg., PMID:27309810
Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization., PMID:27309808
Japanese shrine captures Roman goddess!, PMID:24925828
For research use only. Not for human or drug use.
