Catalog No.
EHC91901
Expression system
Insect Cells
Species
Homo sapiens (Human)
Protein length
Met1-Cys509
Predicted molecular weight
59.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P12081
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HRS, HARS, HisRS, Histidyl-tRNA synthetase, HARS1, Histidine--tRNA ligase, cytoplasmic, Jo-1
Genetic overlap between ALS and other neurodegenerative or neuromuscular disorders., PMID:37849306
A missense, loss-of-function YARS1 variant in a patient with proximal-predominant motor neuropathy., PMID:36307205
Clinical characteristics and proteome modifications in two Charcot-Marie-Tooth families with the AARS1 Arg326Trp mutation., PMID:35971119
The Antiepileptic Valproic Acid Ameliorates Charcot-Marie-Tooth 2W (CMT2W) Disease-Associated HARS1 Mutation-Induced Inhibition of Neuronal Cell Morphological Differentiation Through c-Jun N-terminal Kinase., PMID:35380399
Variants of aminoacyl-tRNA synthetase genes in Charcot-Marie-Tooth disease: A Korean cohort study., PMID:34813128
Evidence for a dominant-negative mechanism in HARS1-mediated peripheral neuropathy., PMID:32940403
Neuropathy-associated histidyl-tRNA synthetase variants attenuate protein synthesis in vitro and disrupt axon outgrowth in developing zebrafish., PMID:32543048
Diagnostic yield of targeted sequential and massive panel approaches for inherited neuropathies., PMID:32506583
Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome., PMID:32333447
Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome., PMID:21464306
For research use only. Not for human or drug use.
