Catalog No.
YHN43401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His394
Predicted molecular weight
46.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6P6C2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALKBH5, ABH5, OFOXD1, RNA demethylase ALKBH5, Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
Low-Dose Lipopolysaccharide Alleviates Neuronal Apoptosis and Oxidative Stress in Rats with Spinal Cord Injury by Inducing Nrf2 m6A Methylation Modification via Suppressing ALKBH5., PMID:40481942
Enterovirus 71 structural viral protein 1 promotes the expression of PMP22 through m6A modification in mouse Schwann cells., PMID:40480313
tRF16 affects NFKBIA stability and promotes osteoarthritis progression by regulating ALKBH5 expression in m6A-dependent manner., PMID:40473927
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer., PMID:40448344
ALKBH5 mediates FGF21 m6A demethylation in human bone marrow mesenchymal stem cells under high glucose conditions., PMID:40441069
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia., PMID:40435251
m6A modification-dependent upregulation of WNT2 facilitates M2-like macrophage polarization and perpetuates malignant progression of nasopharyngeal carcinoma., PMID:40419792
ALKBH5 reverses romidepsin-mediated anti-multiple myeloma activity via regulation of m6A modification of FOXM1., PMID:40419197
N6-methyladenosine RNA base modification regulates NKG2D-dependent and cytotoxic genes expression in natural killer cells., PMID:40389988
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC., PMID:40381190
Role and mechanisms of m6A demethylases in digestive system tumors., PMID:40371134
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression., PMID:40370540
[Effect of Xingnao Kaiqiao acupuncture technique on m6A methylation modification in cortical area of rats with cerebral ischemia-reperfusion injury]., PMID:40369924
Analysis of Genotype and Expression of FTO and ALKBH5 in a MENA-Region Renal Cell Carcinoma Cohort., PMID:40361322
CXCL9 is a dual‑role biomarker in colorectal cancer linked to mitophagy and modulated by ALKBH5., PMID:40341964
RNA demethylase ALKBH5 regulates cell cycle progression in DNA damage response., PMID:40341728
METTL3-dependent m6A modification of SNAP29 induces "autophagy-mitochondrial crisis" in the ischemic microenvironment after soft tissue transplantation., PMID:40340690
Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet., PMID:40334773
Cancer-Specific RNA Modifications in Tumour-Derived Extracellular Vesicles Promote Tumour Growth., PMID:40326665
FTO downregulation-mediated m6A modification resulting in enhanced hepatocellular carcinoma invasion., PMID:40316995
Vaccarin treats lactation insufficiency through the ALKBH5-SFRP2-Wnt/β-catenin signaling pathway., PMID:40311715
Inhibition of ALKBH5 demethylase of m6A pathway potentiates HIV-1 reactivation from latency., PMID:40296171
Aberrant overexpression of m6A writer and reader genes in pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL)., PMID:40288000
Insight into mechanism of ALKBH5-mediated N6-methyladenosine (m6A) regulating porcine epidemic diarrhea virus infection in IPEC-J2 cells., PMID:40280045
Inhibition of Alkbh5 Attenuates Lipopolysaccharide-Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment., PMID:40254698
Alkbh5 promotes Ythdf1 expression through demethylation thereby facilitating Fth1 translation to inhibit ferroptosis of myocardial infarction., PMID:40251485
Deciphering single-cell landscape unravels cell-type-specific functional roles of RNA m6A modification in atherosclerosis., PMID:40225569
The microbiota-m6A-metabolism axis: Implications for therapeutic strategies in gastrointestinal cancers., PMID:40222422
Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis., PMID:40222158
Soufeng Sanjie formula alleviates the progression of lupus and joint injury by regulating the ALKBH5-FoxO1-PFKFB3 axis in M-MDSCs., PMID:40215825
ALKBH5 Improves the Epithelial Cell Tight Junctions to Inhibit Escherichia coli-Induced Mastitis., PMID:40214476
Cell-Type-Specific mRNA N6-Methyladenosine Landscape and Regulatory Mechanisms Underlying Immune Dysregulation of Sleep-Deprived., PMID:40214141
ALKBH5 Inhibits YTHDF2-m6A-Mediated Degradation of RCN1 mRNA to Promote Keloid Formation by Activating IRE1α-XBP1-Mediated ER Stress., PMID:40214031
m6A demethylase ALKBH5 reduces ferroptosis in diabetic retinopathy through the m6A-YTHDF1-ACSL4 axis., PMID:40210448
Transcriptomic analysis reveals the function of m6A regulators in aged cochlea., PMID:40198960
Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression., PMID:40186131
ALKBH5 Regulates Macrophage Senescence and Accelerates Atherosclerosis by Promoting CCL5 m6A Modification., PMID:40177773
RNA modifications in the tumor microenvironment: insights into the cancer-immunity cycle and beyond., PMID:40176140
ALKBH5-mediated m6A regulates the alternative splicing events of SRSF10 in ovarian cancer., PMID:40175608
METTL3, an Independent Adverse Prognostic Factor for AML, Promotes the Development of AML by Modulating the PGC-1α-MAPK Pathway and PGC-1α-Antioxidant System Axis., PMID:40171845
Cigarette smoking modulates m6A modification, affecting the induction of CYP1A1 mRNA by regulating human ARNT and AHRR in A549 cells., PMID:40118351
Diabetic kidney disease: m6A modification as a marker of disease progression and subtype classification., PMID:40103797
m6A RNA methylation dynamics during in vitro maturation of cumulus-oocyte complexes derived from adult or prepubertal sheep., PMID:40097858
AC074117.1/miR-193a-3p axis regulates the malignant progression of uterine corpus endometrial carcinoma via the m6A-related gene ALKBH5., PMID:40064293
Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities., PMID:40022879
The m6A demethylase FTO promotes C/EBPβ-LIP translation to perform oncogenic functions in breast cancer cells., PMID:40022434
Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling., PMID:40014709
Novel Insight of N6-Methyladenosine in Cardiovascular System., PMID:40005339
M6A Demethylase ALKBH5 in Human Diseases: From Structure to Mechanisms., PMID:40001461
Prognostic value of IFI27 in HNSCC and functional analysis under ALKBH5 regulation., PMID:39994291
For research use only. Not for human or drug use.
