Catalog No.
YHN43101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met607-Lys787
Predicted molecular weight
35.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5GLZ8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HECT domain and RCC1-like domain-containing protein 4, HERC4, KIAA1593, Probable E3 ubiquitin-protein ligase HERC4, HECT-type E3 ubiquitin transferase HERC4
METTL3 and HERC4: Elevated Expression and Impact on Hepatocellular Carcinoma Progression., PMID:39611657
A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma., PMID:38838551
Small molecule induced STING degradation facilitated by the HECT ligase HERC4., PMID:38811577
Harnessing genetic interactions for prediction of immune checkpoint inhibitors response signature in cancer cells., PMID:38797232
HERC4 modulates ovarian cancer cell proliferation by regulating SMO-elicited hedgehog signaling., PMID:38181892
The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination., PMID:37028761
RALY regulate the proliferation and expression of immune/inflammatory response genes via alternative splicing of FOS., PMID:35941292
SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization., PMID:35244538
Proteomics Analysis of Andrographolide-Induced Apoptosis via the Regulation of Tumor Suppressor p53 Proteolysis in Cervical Cancer-Derived Human Papillomavirus 16-Positive Cell Lines., PMID:34202736
Reproductive injury in male BALB/c mice infected with Neospora caninum., PMID:33726783
Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study., PMID:33020551
HERC4 exerts an anti-tumor role through destabilizing the oncoprotein Smo., PMID:31010679
E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation., PMID:30925584
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1., PMID:30710319
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer., PMID:29807510
Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity., PMID:29669830
Heterogeneous expression and biological function of SOX18 in osteosaroma., PMID:29266413
SIRT1/HERC4 Locus Associated With Bisphosphonate-Induced Osteonecrosis of the Jaw: An Exome-Wide Association Analysis., PMID:28856724
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells., PMID:28430527
[RNA interference of HERC4 inhibits proliferation, apoptosis and migration of cervical cancer Hela cells]., PMID:28219869
Transcriptome profiling of the antiviral immune response in Atlantic cod macrophages., PMID:27255218
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice., PMID:26825710
Functional and pathological relevance of HERC family proteins: a decade later., PMID:26801221
Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4., PMID:26125558
Expression of HERC4 in lung cancer and its correlation with clinicopathological parameters., PMID:25684480
[Expression of E3 ligase HERC4 in breast cancer and its clinical implications]., PMID:25176076
Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome., PMID:23459991
Impact of asymptomatic nodavirus carrier state and intraperitoneal viral mimic injection on brain transcript expression in Atlantic cod (Gadus morhua)., PMID:20442246
[Influence of Tripterygium wilfordii on the expression of spermiogenesis related genes Herc4, Ipo11 and Mrto4 in mice]., PMID:19819847
Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse., PMID:19148549
Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility., PMID:17967448
The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects., PMID:15676274
For research use only. Not for human or drug use.
