Catalog No.
YHF70001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro737
Predicted molecular weight
82.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P78563
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RNA-editing deaminase 1, ADARB1, RED1, Double-stranded RNA-specific editase 1, dsRNA adenosine deaminase, ADAR2, DRADA2, RNA-editing enzyme 1
Computer-Aided Discovery of Natural Compounds Targeting the ADAR2 dsRBD2-RNA Interface and Computational Modeling of Full-Length ADAR2 Protein Structure., PMID:40362314
Identification of shared pathophysiological molecules of major psychiatric disorders: A comprehensive analysis of serum immune complex antigens before and after electroconvulsive therapy., PMID:40306147
Roles for Androgen Receptor, ADAR2, and PD-L1 in Primary Urothelial Carcinoma In Situ of the Bladder Treated with Bacillus Calmette-Guérin Therapy., PMID:40010639
Comparison of CRISPR-Cas13b RNA base editing approaches for USH2A-associated inherited retinal degeneration., PMID:39922978
Structural analysis of human ADAR2-RNA complexes by X-ray crystallography., PMID:39870445
Nanocarriers Targeting Circular RNA ADARB1 Boost Radiosensitivity of Nasopharyngeal Carcinoma through Synergically Promoting Ferroptosis., PMID:39467079
Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression., PMID:39445805
RNA Editing by ADAR Adenosine Deaminases in the Cell Models of CAG Repeat Expansion Diseases: Significant Effect of Differentiation from Stem Cells into Brain Organoids in the Absence of Substantial Influence of CAG Repeats on the Level of Editing., PMID:39245456
Genetic variants of m6A modification genes are associated with survival of HBV-related hepatocellular carcinoma., PMID:39163514
Revealing Differential RNA Editing Specificity of Human ADAR1 and ADAR2 in Schizosaccharomyces pombe., PMID:39062677
The role of distinct APOBEC/ADAR mRNA levels in mutational signatures linked to aging and ultraviolet radiation., PMID:38965255
Divergent landscapes of A-to-I editing in postmortem and living human brain., PMID:38926387
Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson's disease and dementia with Lewy bodies., PMID:38761794
Perivascular Adipose Tissue Remodels Only after Elevation of Blood Pressure in the Dahl SS Rat Fed a High-Fat Diet., PMID:38113863
Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS., PMID:37547318
Orchestration of a blood-derived and ADARB1-centred network in Alzheimer's and Parkinson's disease., PMID:37544632
A Comprehensive Evaluation of the Effects of RNA-Editing Proteins ADAR and ADARB1 on the Expression of the Drug-Metabolizing Enzymes in HepaRG Cells., PMID:37532539
Molecular Docking and Dynamics Simulation Studies Predict Potential Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer, Neurological, Immunological and Infectious Diseases., PMID:37047766
Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies., PMID:37036839
KHSRP combines transcriptional and posttranscriptional mechanisms to regulate monocytic differentiation., PMID:36518592
The allelic regulation of tumor suppressor ADARB2 in papillary thyroid carcinoma., PMID:36305508
Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling., PMID:35915245
ADAR2 enzymes: efficient site-specific RNA editors with gene therapy aspirations., PMID:35863867
Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus., PMID:35271662
The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma., PMID:35202641
Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA editing activity and specificity., PMID:35044296
Transcription Factors Leading to High Expression of Neuropeptide L1CAM in Brain Metastases from Lung Adenocarcinoma and Clinical Prognostic Analysis., PMID:35003395
Lung fibrosis is induced in ADAR2 overexpressing mice via HuR-induced CTGF signaling., PMID:34985777
Pterostilbene ameliorates the disrupted Adars expression and improves liver fibrosis in DEN-induced liver injury in Wistar rats: A novel potential effect., PMID:34921950
Comparison of the transcriptome in circulating leukocytes in early lactation between primiparous and multiparous cows provides evidence for age-related changes., PMID:34563126
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair., PMID:34535666
Developing PspCas13b-based enhanced RESCUE system, eRESCUE, with efficient RNA base editing., PMID:34380502
An I for an A: Dynamic Regulation of Adenosine Deamination-Mediated RNA Editing., PMID:34356042
Regulation and functional consequences of mGlu4 RNA editing., PMID:34244459
The RNA editing enzyme ADAR2 restricts L1 mobility., PMID:34224323
Regulation of RNA editing by intracellular acidification., PMID:33721028
RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior., PMID:33627618
Short-Chain Guide RNA for Site-Directed A-to-I RNA Editing., PMID:33170095
Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing., PMID:33147453
RNA editing in cancer impacts mRNA abundance in immune response pathways., PMID:33106178
Distant coupling between RNA editing and alternative splicing of the osmosensitive cation channel Tmem63b., PMID:33100268
RNA timestamps identify the age of single molecules in RNA sequencing., PMID:33077959
REPAIRx, a specific yet highly efficient programmable A > I RNA base editor., PMID:33058207
ADAR-deficiency perturbs the global splicing landscape in mouse tissues., PMID:32727871
Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy., PMID:32719099
Fibroblast Growth Factor-14 Acts as Tumor Suppressor in Lung Adenocarcinomas., PMID:32707902
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis., PMID:32693003
ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility., PMID:32665638
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs., PMID:32603639
Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition., PMID:32597966
For research use only. Not for human or drug use.
