Catalog No.
YHN42901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser481
Predicted molecular weight
53.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5VV17
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DUBA7, DUBA-7, OTUD1, OTU domain-containing protein 1, OTDC1
OTUD1 exacerbates sepsis-associated encephalopathy by promoting HK2 mitochondrial release to drive microglia pyroptosis., PMID:40500776
OTUD1 inhibits macrophage ferroptosis via regulation of AMPK and GSK3β/β-catenin signaling pathways exerting protective effects in sepsis-induced acute lung injury., PMID:40460602
METTL3‑mediated m6A methylation and its impact on OTUD1 expression in chronic obstructive pulmonary disease., PMID:40417884
OTUD1 deficiency attenuates myocardial ischemia/reperfusion induced cardiomyocyte apoptosis by regulating RACK1 phosphorylation., PMID:40394237
Black carp OTUD1 negatively regulates antiviral innate immunity via deubiquitination and degradation of IRF3/7., PMID:40350101
OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer's disease by deubiquitinating C/EBPβ., PMID:40335710
OTUD1 delays wound healing by regulating endothelial function and angiogenesis in diabetic mice., PMID:40300668
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7., PMID:40279273
A positive feedback loop of OTUD1 and c-Jun driven by leptin expedites stemness maintenance in ovarian cancer., PMID:40108305
The Deubiquitinase OTUD1 Influences HIV-1 Release by Regulating the Host Restriction Factor BST-2., PMID:40007014
Identification and optimization of a small molecule inhibitor of the ovarian tumor protease of the Crimean-Congo hemorrhagic fever virus., PMID:39923558
Ubiquitin-Proteasome System in Periodontitis: Mechanisms and Clinical Implications., PMID:39626954
OTUD1 regulates cytokine expression and related pathways in goose fatty liver by promoting deubiquitination of its target proteins., PMID:39437555
Decoding polyubiquitin regulation of KV7. 1 functional expression with engineered linkage-selective deubiquitinases., PMID:39345403
METTL3-mediated m6A modification of OTUD1 aggravates press overload induced myocardial hypertrophy by deubiquitinating PGAM5., PMID:39309432
Mineralocorticoid Receptor Signaling in Peripheral Blood Cells in Patients with Multiple Sclerosis., PMID:39201568
Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling., PMID:39118286
The deubiquitinase OTUD1 stabilizes NRF2 to alleviate hepatic ischemia/reperfusion injury., PMID:39079388
The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-κB signaling., PMID:38996928
BECN1 regulates FADD/RIPK1/Caspase-8 complex formation via RIPK1 ubiquitination by downregulating OTUD1 in MI/R induced myocyte apoptosis., PMID:38744338
OTUD1 enhances gastric cancer aggressiveness by deubiquitinating EBV-encoded protein BALF1 to stabilize the apoptosis inhibitor Bcl-2., PMID:38565386
Pigeon novel-miR-741 targets OTUD1 to inhibit proliferation and promote apoptosis of crop fibroblasts., PMID:38479099
Aggresome formation promotes ASK1/JNK signaling activation and stemness maintenance in ovarian cancer., PMID:38351029
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes., PMID:38185350
OTUD1 promotes hypertensive kidney fibrosis and injury by deubiquitinating CDK9 in renal epithelial cells., PMID:38110583
OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2., PMID:38012669
The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer., PMID:37872170
Herpesvirus latent infection promotes stroke via activating the OTUD1/NF-κB signaling pathway., PMID:37695739
The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil Polarization And Ameliorates Immunopathology of Periodontitis., PMID:37639212
Development of an OTUD1 ubiquitin variant inhibitor., PMID:37589489
Identification of TGF-β-related genes in cardiac hypertrophy and heart failure based on single cell RNA sequencing., PMID:37498303
OTUD1 chemosensitizes triple-negative breast cancer to doxorubicin by modulating P16 expression., PMID:37257246
OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes., PMID:37153745
Targeting a deubiquitinase blocks GVHD., PMID:36951887
VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma., PMID:36929488
Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1., PMID:36829909
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region., PMID:36640312
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3., PMID:36579465
The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease., PMID:36574342
Differential gene co-expression network analyses reveal novel molecules associated with transcriptional dysregulation of key biological processes in osteoarthritis knee cartilage., PMID:36474801
Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs., PMID:36445135
Differences of macrophages in the tumor microenvironment as an underlying key factor in glioma patients., PMID:36389681
The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma., PMID:36357400
OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways., PMID:35941131
Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis., PMID:35821088
OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs., PMID:35280681
Molecular Mechanism of Sevoflurane Preconditioning Based on Whole-transcriptome Sequencing of Lipopolysaccharide-induced Cardiac Dysfunction in Mice., PMID:35266915
The deubiquitinase OTUD1 inhibits non-small cell lung cancer progression by deubiquitinating and stabilizing KLF4., PMID:35098684
The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling., PMID:34876703
Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation., PMID:34826170
For research use only. Not for human or drug use.
