Catalog No.
YHB69801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile227
Predicted molecular weight
53.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95619
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gas41, Glioma-amplified sequence 41, YEATS4, GAS41, NuBI1, NuBI-1, YEATS domain-containing protein 4, NuMA-binding protein 1
Clinical and molecular risk factors for repeat interventions due to symptomatic uterine leiomyomas., PMID:39094728
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer., PMID:38964523
Targeting the KAT8/YEATS4 Axis Represses Tumor Growth and Increases Cisplatin Sensitivity in Bladder Cancer., PMID:38526153
Development of Complementary Photo-arginine/lysine to Promote Discovery of Arg/Lys hPTMs Interactomes., PMID:38298064
Small-molecule tools for YEATS domain proteins., PMID:37924571
Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4., PMID:37435030
Clinical and Genomic Characteristics of Patients with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors., PMID:37289194
Identification of biomarkers, pathways, and potential therapeutic targets for heart failure using next-generation sequencing data and bioinformatics analysis., PMID:37092838
Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau., PMID:37000417
Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas., PMID:36773604
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4., PMID:36562986
GAS41 mediates proliferation and GEM chemoresistance via H2A.Z.2 and Notch1 in pancreatic cancer., PMID:35503594
Differential Expression of Zinc-Dependent HDAC Subtypes and their Involvement in Unique Pathways Associated with Carcinogenesis., PMID:35345359
Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases., PMID:35279775
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma., PMID:34349258
Development of potent dimeric inhibitors of GAS41 YEATS domain., PMID:34289376
Clinical Application of Chromosome Microarray Analysis in the Diagnosis of Lipomatous Tumors., PMID:33734108
YEATS4 is associated with poor prognosis and promotes epithelial-to-mesenchymal transition and metastasis by regulating ZEB1 expression in breast cancer., PMID:33575079
Recent Advancement in Atypical Lipomatous Tumor Research., PMID:33498189
Epigenetic regulation of virulence and the transcription of ribosomal protein genes involves a YEATS family protein in Cryptococcus deneoformans., PMID:33440003
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription., PMID:31434684
Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma., PMID:30662802
Abnormal expression of YEATS4 associates with poor prognosis and promotes cell proliferation of hepatic carcinoma cell by regulation the TCEA1/DDX3 axis., PMID:30416857
GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode., PMID:30071723
lncAKHE enhances cell growth and migration in hepatocellular carcinoma via activation of NOTCH2 signaling., PMID:29706630
Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation., PMID:29463709
Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer., PMID:29437725
Identification of commonly altered genes between in major depressive disorder and a mouse model of depression., PMID:28596527
YEATS4 promotes the tumorigenesis of pancreatic cancer by activating beta-catenin/TCF signaling., PMID:28445953
YEATS Domain Containing 4 Promotes Gastric Cancer Cell Proliferation and Mediates Tumor Progression via Activating the Wnt/β-Catenin Signaling Pathway., PMID:28251887
Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagy., PMID:27779719
Regulation of Cell Proliferation and Migration by miR-203 via GAS41/miR-10b Axis in Human Glioblastoma Cells., PMID:27467502
Genomewide copy number analysis of Müllerian adenosarcoma identified chromosomal instability in the aggressive subgroup., PMID:27255164
Transcriptome analysis indicates TFEB1 and YEATS4 as regulatory transcription factors for drug resistance of ovarian cancer., PMID:26307679
Characterization of the 12q amplicons in lipomatous soft tissue tumors by multiplex ligation-dependent probe amplification-based copy number analysis., PMID:25862836
Longitudinal muscle gene expression patterns associated with differential intramuscular fat in cattle., PMID:25391663
Characterization and inhibition of AF10-mediated interaction., PMID:24692230
YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway., PMID:24170126
GAS41 amplification results in overexpression of a new spindle pole protein., PMID:22619067
Searching for molecular targets in sarcoma., PMID:22387046
Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression., PMID:22350108
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans., PMID:22144904
Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours., PMID:22068108
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability., PMID:21317290
The YEATS family member GAS41 interacts with the general transcription factor TFIIF., PMID:20618999
HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon., PMID:18214854
Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line., PMID:18160213
The chromatin structure of the lysozyme GAS41 origin of DNA replication changes during the cell cycle., PMID:18064355
A high-throughput loss-of-function screening identifies novel p53 regulators., PMID:16929179
GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation., PMID:16705155
For research use only. Not for human or drug use.
