Catalog No.
YHC84903
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr500-Leu654
Predicted molecular weight
21.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P11021
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Heat shock protein 70 family protein 5, 78 kDa glucose-regulated protein, HSPA5, Binding-immunoglobulin protein, GRP-78, HSP70 family protein 5, Heat shock protein family A member 5, Endoplasmic reticulum chaperone BiP, GRP78, BiP, Immunoglobulin heavy chain-binding protein
Therapeutic potential of BOLD-100, a GRP78 inhibitor, enhanced by ATR inhibition in pancreatic ductal adenocarcinoma., PMID:40514666
Loss of FIC-1-mediated AMPylation activates the UPRER and upregulates cytosolic HSP70 chaperones to suppress polyglutamine toxicity., PMID:40512832
Antitumor Effect of Isoliquiritigenin via Mitochondrial Dysfunction and Oxidative Stress in Cholangiocarcinoma Cells., PMID:40512556
Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer., PMID:40506749
Endoplasmic reticulum stress markers in tularemia: a case-control study., PMID:40505331
Impact of grape seed proanthocyanidin B2 pretreatment on mitochondrial oxidative stress, endoplasmic reticulum stress, and apoptosis in renal tubular epithelial cells during in-vitro hypoxia-reoxygenation., PMID:40498953
The Neuroprotective Effects of the Crinoid Natural Compound Rhodoptilometrin in Parkinson's Disease Experimental Models: Implications for ER Stress and Autophagy Modulation., PMID:40498105
Modulation of ER Stress and Inflammation by S-Ketamine, R-Ketamine, and Their Metabolites in Human Microglial Cells: Insights into Novel Targets for Depression Therapy., PMID:40498007
EBBP-Mediated Integrated Stress Response Attenuates Anthracycline-Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes., PMID:40491313
The expression of fungal CotH, human glucose-regulated protein 78 (GRP78), and predicted miRNAs in macrophages and diabetic mice infected with Rhizopus oryzae., PMID:40488471
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells., PMID:40487653
Maternal high-fat diet impairs cognitive performance by altering hippocampal GRP78/PERK axis and BDNF expression in adult female rat offspring: the potential protective role of N acetylcysteine., PMID:40481912
Clearance of protein aggregates during cell division., PMID:40476343
Exploring heat shock protein-related biomarkers and subgroups in osteoarthritis using Gene Expression Omnibus data sets., PMID:40474128
Alcohol, Anti-HIV Drugs, and/or Hippuric Acid Deteriorate Cellular Stresses in Senescent Hepatocytes and Aging Murine Liver., PMID:40463894
Transcriptional regulation of solute carrier family 6 member 9 gene., PMID:40461883
Vitexin-4 ″-O-glucoside alleviates acetaminophen-induced acute liver injury in mice by inhibiting endoplasmic reticulum stress., PMID:40461289
Autophagy hub-protein p62 orchestrates oxidative, endoplasmic reticulum stress, and inflammatory responses post-ischemia, exacerbating stroke outcome., PMID:40460555
Bisacurone ameliorates myocardial ischemia/reperfusion injury in rats: regulation of inflammatory and apoptosis pathways via CHOP/GRP78 proteins., PMID:40457385
Toxicoproteomic study of fipronil in SH-SY5Y cells reveals induction of endoplasmic reticulum stress and necrotic cell death as neurodegenerative mechanisms., PMID:40449641
Dietary resveratrol alleviates liver and intestinal injury in ducks under cage rearing system., PMID:40449104
Orf132: a critical gene for LSDV replication and its role in Er stress-related apoptosis., PMID:40448160
Continuous exposure to low concentrations of antimony(III) induces inflammation, apoptosis, oxidative and endoplasmic reticulum stress in Caco-2 intestinal epithelial cells., PMID:40447031
The Ameliorative Effect of Adipose-Derived Mesenchymal Stem Cells and Their Exosomes in Non-alcoholic Steatohepatitis by Simultaneously Enhancing Autophagic Flux and Suppressing Endoplasmic Reticulum Stress., PMID:40438157
Lipid droplet accumulation impairs osseointegration by disturbing the osteogenesis-osteoclasis balance on titanium implant surface in hyperlipidemia., PMID:40437476
Lycopene alleviates splenic injury in grass carp (Ctenopharyngodon idella) caused by endoplasmic reticulum stress-autophagy axis induced by sulfamethoxazole through regulating AKT/AMPK pathway., PMID:40436289
Fufang zhenzhu tiaozhi capsule alleviates hypothalamic endoplasmic reticulum stress and leptin resistance through autophagy modulation in DIO rats., PMID:40436122
Screening and identification of protein interacting with goose astrovirus., PMID:40433662
Manganese Porphyrin Treatment Improves Redox Status Caused by Acute Compressive Spinal Cord Trauma., PMID:40427469
Ranolazine as a therapeutic agent for diabetic cardiomyopathy: reducing endoplasmic reticulum stress and inflammation in type 2 diabetic rat model., PMID:40426266
Docosahexaenoic Acid Attenuates Endoplasmic Reticulum Stress-Induced Neuron Apoptosis by Targeting Presenilin 2., PMID:40415367
Arctigenin Attenuates Hepatic Stellate Cell Activation via Endoplasmic Reticulum-Associated Degradation (ERAD)-Mediated Restoration of Lipid Homeostasis., PMID:40415275
Endoplasmic Reticulum Stress Induces Liquid-Liquid Phase Separation of GRP78 and Modulates Protein Aggregation Dynamics., PMID:40406897
The impact of copper-induced oxidative damage on the endoplasmic reticulum quality control system in broiler kidneys., PMID:40404888
Therapeutic potential of fisetin in hepatic steatosis: Insights into autophagy pathway regulation and endoplasmic reticulum stress alleviation in high-fat diet-fed mice., PMID:40402993
Myricetin alleviates learning and memory deficits in trimethyltin Alzheimer's phenotype via attenuating hippocampal endoplasmic reticulum stress and regulating inflammation and oxidative stress., PMID:40383238
Unveiling the crosstalk between unfolded protein response and apoptosis in triclosan induced hepatotoxicity in Labeo rohita., PMID:40379834
Mechanical effect of protein glycosylation on BiP-mediated post-translational translocation and folding in the endoplasmic reticulum., PMID:40376427
Nephroprotective effects of hesperidin on ifosfamide-induced acute nephrotoxicity in rats: Role of NF-κB/TNF-α/ IL-1β, p53/caspase-3/Bax/Bcl-2, and ATF6/IRE1/PERK/GRP78 signaling pathways., PMID:40373990
Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis., PMID:40371728
The Role of Endoplasmic Reticulum Stress in Fine Particulate Matter-Induced Phenotype Switching of Vascular Smooth Muscle Cells., PMID:40369400
BiP, GRP94, calreticulin and calnexin contribute to development of the notochord in medaka fish., PMID:40368802
Computational investigation of the interplay between cellular stress and ferroptosis in triple-negative breast cancer., PMID:40367895
Ophiopogonin D improves pancreatic islet cell dedifferentiation to treat diabetes by regulating the GRP78/ROS/PDX1 signaling pathway., PMID:40365319
Role of T3 in the Regulation of GRP78 on Granulosa Cells in Rat Ovaries., PMID:40362432
Implications of Chitinase 3-like 1 Protein in the Pathogenesis of Multiple Sclerosis in Autopsied Brains and a Murine Model., PMID:40362399
In silico prediction of GRP78-CRIPTO binding sites to improve therapeutic targeting in glioblastoma., PMID:40360533
Endoplasmic reticulum stress regulates swainsonine-induced the autophagy in renal tubular epithelial cells through UPR signaling pathway., PMID:40354703
[Effects of total flavonoids of Dracocephalum moldavica on apoptosis of H9c2 cells induced by OGD/R injury and endoplasmic reticulum stress]., PMID:40350915
[Congrong San ameliorates cognitive impairment and neuroinflammation in rat model of Alzheimer's disease by alleviating endoplasmic reticulum stress to inhibit NLRP3 inflammasome activation]., PMID:40350880
For research use only. Not for human or drug use.
