Catalog No.
PMG84901
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse Il11ra1/Etl-2/NR1 (Gly34-Thr314).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
IL-11RA, sIL-11R, Interleukin-11 receptor subunit alpha, sIL-11RA, IL11RA, IL-11R-alpha, IL-11R subunit alpha, IL-11 receptor subunit alpha, sIL11RA
Purification
Purified by antigen affinity column.
Accession
Q64385
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan., PMID:39020175
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome., PMID:36924234
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease., PMID:36470928
A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome., PMID:35140116
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome., PMID:35135328
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts., PMID:34651016
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury., PMID:34108253
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload., PMID:33462828
Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease., PMID:32656894
IL-11 in cardiac and renal fibrosis: Late to the party but a central player., PMID:32022251
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis., PMID:31554736
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis., PMID:31078624
IL-11 regulates autoimmune demyelination., PMID:19734214
Endogenous IL-11 is pro-inflammatory in acute methylated bovine serum albumin/interleukin-1-induced (mBSA/IL-1)arthritis., PMID:15598441
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells., PMID:14701802
Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress., PMID:12730876
Cytokine receptor repertoire and cytokine responsiveness of Ho(dull)/Rh(dull) stem cells with differing potentials for G1/S phase progression., PMID:12135678
Developmental differences in alternative splicing of the NR1 protein in rat cortex and cerebellum., PMID:11042343
Interleukin-11 signals through the formation of a hexameric receptor complex., PMID:10948192
Monoclonal antibodies against the human interleukin-11 receptor alpha-chain (IL-11Ralpha) and their use in studies of human mononuclear cells., PMID:10915848
Mutual education between hematopoietic cells and bone marrow stromal cells through direct cell-to-cell contact: factors that determine the growth of bone marrow stroma-dependent leukemic (HB-1) cells., PMID:9680351
Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro., PMID:9354656
Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain., PMID:8921254
The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures., PMID:8676079
Interleukin-11., PMID:7532057
Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells., PMID:1373723
For research use only. Not for human or drug use.
