Catalog No.
PMD65601
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse GUCY2C/GCC (Gly33-Ala408).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
STAR, Intestinal guanylate cyclase, GC-C, GUC2C, STA receptor, Heat-stable enterotoxin receptor, Guanylyl cyclase C, hSTAR, GUCY2C
Purification
Purified by antigen affinity column.
Accession
Q3UWA6
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
A proteomic atlas of glypican-3 interacting partners: Identification of alpha-fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer., PMID:39822733
Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3., PMID:37591971
The Intestinal Tract Brush Border in Young Children Uniformly Expresses Guanylate Cyclase C., PMID:36735491
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy., PMID:34143379
GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer., PMID:34027103
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors., PMID:33459147
An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer., PMID:32945718
Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate., PMID:32843329
Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity., PMID:32819976
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers., PMID:31996389
Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients., PMID:31010434
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity., PMID:27853651
Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic β Cell Line., PMID:26986842
GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer., PMID:25294806
Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer., PMID:24085786
The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response., PMID:16819406
For research use only. Not for human or drug use.
