Anti-Human CGAS Polyclonal Antibody

Catalog No.

PHN28901

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CGAS (Ser201-Phe522).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

h-cGAS, MB21D1, 2'3'-cGAMP synthase, cGAS, cGAMP synthase, Mab-21 domain-containing protein 1, Cyclic GMP-AMP synthase, CGAS, C6orf150

Purification

Purified by antigen affinity column.

Accession

Q8N884

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Biomimetic Delivery of Cisplatin for Efficient Immunotherapy of Gasdermin E-Positive Hepatocellular Carcinoma via a Pt Concentration-Dependent Minimalist Pyroptosis Strategy., PMID:40509605

Bispecific Antibody Targeting VEGF/TGF-β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects., PMID:40470716

Nanoimmunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer's disease treatment., PMID:40434641

Sterile Inflammation and Cell Death Pathways in Liver Ischemia-Reperfusion Injury: A Review and Perspective., PMID:40396312

A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer., PMID:40394677

Effect and mechanism of the miR-1284/EIF4A1 axis on the cGAS-STING pathway under radiotherapy., PMID:40386253

[Buzhong Yiqi Decoction alleviates immune injury of autoimmune thyroiditis in NOD.H-2~(h4)mice via c GAS-STING signaling pathway]., PMID:40350879

Microbial dysbiosis fuels STING-driven autoinflammation through cyclic dinucleotides., PMID:40334619

[Effects of lipopolysaccharide-activated interferon gene stimulator signaling on periodontal ligament cells]., PMID:40268534

[Establishment of a sandwich ELISA method for CHGA in saliva samples and its preliminary application in stress detection]., PMID:40260565

Nanobody Engineered and Photosensitiser Loaded Bacterial Outer Membrane Vesicles Potentiate Antitumour Immunity and Immunotherapy., PMID:40240911

The therapeutic promise of probiotic Bacteroides fragilis (BF839) in cancer immunotherapy., PMID:40231233

Oncolytic peptide LTX-315 plus an anti-CTLA-4 antibody induces a synergistic anti-cancer immune response in residual tumors after radiofrequency ablation of hepatocellular carcinoma., PMID:40222972

Nanosized Shikonin Disrupts Tumor-Cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy., PMID:40190094

Catestatin-like immunoreactivity in the skin and related sensory ganglia., PMID:40179527

Mineralized Bacteria as a Potent Vaccine Against Staphylococcus aureus Infections., PMID:40178324

Chemotherapy-Mediated Induction of PD-L1 via SEI1 Facilitates Myeloma Immune Evasion., PMID:40135791

A lupus-derived autoantibody that binds to intracellular RNA activates cGAS-mediated tumor immunity and can deliver RNA into cells., PMID:40132052

Dual-modality immune nano-activator harnessing Mn2⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy., PMID:40128784

Regulation and Function of the cGAS-STING Pathway: Mechanisms, Post-Translational Modifications, and Therapeutic Potential in Immunotherapy., PMID:40098909

PCK1 inhibits cGAS-STING activation by consumption of GTP to promote tumor immune evasion., PMID:40048154

ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion., PMID:40033100

Metal-Phenolic Network Hydrogel Vaccine Platform for Enhanced Humoral Immunity against Lethal Rabies Virus., PMID:40025824

Catestatin and Advanced Glycation End-Products: Potential Indicators of Cardiovascular Risk in Hashimoto's Thyroiditis., PMID:40001472

Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy., PMID:39994712

Just Autoimmunity? The Role of the Innate Immune Response in Lupus., PMID:39970447

Whole-Component Antigen Nanovaccines Combined With aTIGIT for Enhanced Innate and Adaptive Anti-tumor Immunity., PMID:39967373

Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease., PMID:39962970

Pancreatic Neuroendocrine Tumors-Diagnostic Pitfalls of Non-Diabetic Severe Hypoglycemia: Literature Review and Case Report., PMID:39941267

STING activation and overcoming the challenges associated with STING agonists using ADC (antibody-drug conjugate) and other delivery systems., PMID:39922441

Chemotherapy boosts anti-angiogenic and anti-PD-1 combination therapy through activation of cCAS-STING pathway in colon cancer., PMID:39904029

Immune checkpoint inhibitors mediate myocarditis by promoting macrophage polarization via cGAS/STING pathway., PMID:39884185

Facile integration of a binary nano-prodrug with αPD-L1 as a translatable technology for potent immunotherapy of TNBC., PMID:39870152

PLGA co-loaded Salvia miltiorrhiza polysaccharide and Mn2+ as an adjuvant to induce potent immunity., PMID:39855513

Activating the cGAS-STING Pathway by Manganese-Based Nanoparticles Combined with Platinum-Based Nanoparticles for Enhanced Ovarian Cancer Immunotherapy., PMID:39846241

Lentinan-functionalized PBAE-G-nanodiamonds as an adjuvant to induce cGAS-STING pathway-mediated macrophage activation and immune enhancement., PMID:39840398

A phase II study of ramucirumab and somatostatin analog therapy in patients with advanced neuroendocrine tumors., PMID:39834129

Dominant Expression of Chromogranin B in Pituitary Corticotrophs and Its Putative Role in Interaction With Secretogranin III., PMID:39791490

Bioactive microspheres to enhance sonodynamic-embolization-metalloimmune therapy for orthotopic liver cancer., PMID:39753085

Baicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity., PMID:39710370

ENPP1/CD203a-targeting heavy-chain antibody reveals cell-specific expression on human immune cells., PMID:39694917

Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma., PMID:39658648

Manganese nanosheets loaded with selenium and gemcitabine activate the tumor microenvironment to enhance anti-tumor immunity., PMID:39637652

Bendamustine-rituximab elicits dual tumoricidal and immunomodulatory responses via cGAS-STING activation in diffuse large B-cell lymphoma., PMID:39521616

Immune enhancement of rhamnolipid/manganese calcium phosphate mineralized nanoparticle: A promising subunit antigen delivery system., PMID:39491710

Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy., PMID:39464890

Immunomodulatory effects of trastuzumab deruxtecan through the cGAS-STING pathway in gastric cancer cells., PMID:39449023

Dietary fiber and weaning age affect stress and immune markers in saliva of sows and their offspring., PMID:39394655

Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors., PMID:39379603

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model., PMID:39353433

Document Download

Anti-Human CGAS Polyclonal Antibody.pdf