Catalog No.
PHN28401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TPH2 (Leu148-Ile490).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Neuronal tryptophan hydroxylase, TPH2, Tryptophan 5-monooxygenase 2, Tryptophan 5-hydroxylase 2, NTPH
Purification
Purified by antigen affinity column.
Accession
Q8IWU9
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Proposal for a simple and easy-to-implement protocol for three-dimensional tissue imaging that is compatible with observation using a confocal microscope., PMID:40273593
The response of CD27+CD38+ plasmablasts, CD24hiCD38hi transitional B cells, CXCR5-ICOS+PD-1+ Tph, Tph2 and Tfh2 subtypes to allergens in children with allergic asthma., PMID:38424520
Perinatal Western-style diet alters serotonergic neurons in the macaque raphe nuclei., PMID:36704012
Hypertrophic cardiomyopathy induces changes in the tryptophan-5-hydroxylase, serotonin transporter and serotonergic receptors expressions., PMID:36657118
Triptófano-5-hidroxilasa, transportador de serotonina y receptores serotoninérgicos en miocardiopatía dilatada., PMID:36472833
Tph2 Genetic Ablation Contributes to Senile Plaque Load and Astrogliosis in APP/PS1 Mice., PMID:30827242
Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus., PMID:30803087
Mitochondrial changes and oxidative stress in a mouse model of Zellweger syndrome neuropathogenesis., PMID:27514574
Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis., PMID:27217698
Intraspinal serotonergic neurons consist of two, temporally distinct populations in developing zebrafish., PMID:26437856
Central serotonergic neuron deficiency in a mouse model of Zellweger syndrome., PMID:24881576
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism., PMID:24558199
Characterization of a novel primary culture system of adult zebrafish brainstem cells., PMID:24316294
Selective lesioning of nucleus incertus with corticotropin releasing factor-saporin conjugate., PMID:24287211
Autoantibodies against aromatic amino acid hydroxylases in patients with autoimmune polyendocrine syndrome type 1 target multiple antigenic determinants and reveal regulatory regions crucial for enzymatic activity., PMID:23182718
The effects of glycogen synthase kinase-3beta in serotonin neurons., PMID:22912839
Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition., PMID:22819790
Neuronal serotonin regulates growth of the intestinal mucosa in mice., PMID:22609381
The sea lamprey tryptophan hydroxylase: new insight into the evolution of the serotonergic system of vertebrates., PMID:22527120
Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice., PMID:22232550
Raphe serotonin neurons are not homogenous: electrophysiological, morphological and neurochemical evidence., PMID:21530552
Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation., PMID:21156177
Ultrastructural characterization of tryptophan hydroxylase 2-specific cortical serotonergic fibers and dorsal raphe neuronal cell bodies after MDMA treatment in rat., PMID:21052985
Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain., PMID:19233335
Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation after chronic exposure to hypoxia., PMID:19015006
Comparative analysis of serotonin receptor (HTR1A/HTR1B families) and transporter (slc6a4a/b) gene expression in the zebrafish brain., PMID:18839395
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding., PMID:17973628
Phosphorylation and activation of tryptophan hydroxylase 2: identification of serine-19 as the substrate site for calcium, calmodulin-dependent protein kinase II., PMID:17727633
Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice., PMID:17622221
Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem., PMID:17072838
Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies., PMID:16581041
Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons., PMID:15246835
For research use only. Not for human or drug use.
