Catalog No.
YMC01801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
His55-Ser105
Predicted molecular weight
18.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Z126
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C-X-C motif chemokine 4, PF-4, Oncostatin-A, Endothelial cell growth inhibitor, CXCL4, Iroplact, Platelet factor 4, PF4, SCYB4
Insights into platelet factor 4-derived peptide macrocycles; the mechanistic basis of their rapid and selective antiplasmodial actions., PMID:40490548
The potential role of biomarkers CD28 and PF4 in the pathogenesis of idiopathic pulmonary fibrosis and their impact on the prognosis: an immune microenvironment analysis., PMID:40483519
Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands., PMID:40424780
Enhanced wound healing function of fibronectin variants via fusing with platelet factor 4., PMID:40373928
Classification of Platelet-Activating Anti-Platelet Factor 4 Disorders., PMID:40358013
Endoplasmic reticulum protein 29 negatively regulates platelet functions and thrombosis in mice., PMID:40336049
Longitudinal assessment of immunogenicity of inactivated COVID-19 booster immunization and breakthrough infection in blood donors: A multicenter study from 2021 to 2023., PMID:40323225
Case Report: Anti-platelet factor 4 -mediated immunothrombosis in a patient with ANCA vasculitis - a shared mechanism of NETosis., PMID:40276517
Antiplatelet-anticoagulant, APAC, a mimic of endogenous heparin, is an antithrombotic with von Willebrand factor-mediated characteristics., PMID:40252546
Integrative In-Silico Analysis of Retroperitoneal Tumors in Colorectal Surgery: Advancements and Implications., PMID:40238057
PF4 promotes CXCR3+ Tfh1 cell differentiation through STAT1 in mouse immune thrombocytopenia., PMID:40235276
Refractory delayed-onset heparin induced thrombocytopenia (HIT) without thrombosis, treated with intravenous immunoglobulin., PMID:40233637
PF4-dependent P-selectin expression assay in comparison to the heparin-induced platelet activation assay for the diagnosis of heparin-induced thrombocytopenia., PMID:40191970
Prospective multicenter comparison of the diagnostic value of IgG and IgGAM antibodies for heparin-induced thrombocytopenia., PMID:40187717
Refractory autoimmune heparin-induced thrombocytopenia following cardiac surgery., PMID:40158808
Platelet activation and COPD-related clinical and imaging characteristics: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study., PMID:40147570
The Role of CXCL4 in Systemic Sclerosis: DAMP, Auto-Antigen and Biomarker., PMID:40141068
Heterogeneity and longitudinal transcriptomic characteristics of Tregs in COVID-19 patients., PMID:40114921
Lienal Polypeptide Decreases Immune Thrombocytopenia in a Mouse Model by Upregulating Cytokine Production and Increasing the Levels of CD4+, CD8+, and T Regulatory Cells., PMID:40113259
Platelet-activating cytokines potentially associated with MASLD-induced liver injury significantly decreased following CPAP therapy: A translational study using a fatty liver mouse model., PMID:40112616
Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia., PMID:40085945
Platelet activation stimulates macrophages to enhance ulcerative colitis through PF4/CXCR3 signaling., PMID:40084691
Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder., PMID:40054734
Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis., PMID:40032858
Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response., PMID:39989399
VITT-like Monoclonal Gammopathy of Thrombotic Significance., PMID:39938091
Structural and functional changes underlying activation of monocytes in heparin-induced thrombocytopenia., PMID:39933652
Transplantation of autologous endothelial progenitor cells promotes the repair of fusiform aneurysms., PMID:39923840
Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia., PMID:39901742
Identification of disulfide bond-linking sites in biosynthesized platelet factor 4 by establishing a partial reduction method without alkylation., PMID:39865791
Inovirus-Encoded Peptides Induce Specific Toxicity in Pseudomonas aeruginosa., PMID:39861901
The Platelet-Specific Gene Signature in the Immunoglobulin G4-Related Disease Transcriptome., PMID:39859144
Decreased serum PF4 levels correlate with cognitive decline and CSF biomarkers in Alzheimer's disease in a Chinese cohort., PMID:39855320
PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer., PMID:39815258
α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment., PMID:39813624
Observation on the efficacy of TPO receptor agonists and platelet transfusion in chemotherapy-induced thrombocytopenia in malignant tumors., PMID:39810144
Complex Pattern of Platelet Activation/Reactivity After SARS-CoV-2 Infection., PMID:39795908
Platelet factor 4-derived C15 peptide broadly inhibits enteroviruses by disrupting viral attachment., PMID:39772852
Complement activation as a biomarker for platelet-activating antibodies in heparin-induced thrombocytopenia., PMID:39725085
Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody-induced immunothrombosis., PMID:39705541
Platelets as key cells in endometriosis patients: Insights from small extracellular vesicles in peritoneal fluid and endometriotic lesions analysis., PMID:39698929
PF4 Silencing Promotes Trophoblast Cell Proliferation, Migration, Invasion and EMT by Regulating SOCS3/STAT3 Signaling Pathway., PMID:39694960
Nbeal2 knockout mice are not protected against hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension., PMID:39693512
Imaging flow cytometry as a novel approach for the diagnosis of heparin-induced thrombocytopenia., PMID:39658032
Effect of proanthocyanidins on cognitive improvement in thyroxin-induced aging mice., PMID:39651563
Demystifying autoimmune HIT: what it is, when to test, and how to treat., PMID:39644061
S6K/FLNC/ITGβ3 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin., PMID:39612888
PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway., PMID:39601768
Prothrombotic antibodies targeting the spike protein's receptor-binding domain in severe COVID-19., PMID:39576992
Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity., PMID:39571033
For research use only. Not for human or drug use.
