Catalog No.
YMG73401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Phe29-Gly358
Predicted molecular weight
39.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9JLQ2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0148, Cool-interacting tyrosine-phosphorylated protein 2, CAT-2, GRK-interacting protein 2, GIT2, G protein-coupled receptor kinase-interactor 2, ARF GTPase-activating protein GIT2, ARF GAP GIT2, CAT2
Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C., PMID:40176062
Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection., PMID:40019803
GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs., PMID:39954559
Git2 deficiency promotes MDSCs recruitment in intestine via NF-κB-CXCL1/CXCL12 pathway and ameliorates necrotizing enterocolitis., PMID:39074614
Identification of exosomal microRNAs and related hub genes associated with imatinib resistance in chronic myeloid leukemia., PMID:38916832
CD24 promotes metastasis and chemoresistance by directly targeting Arf6-ERK pathway in esophageal squamous cell carcinoma., PMID:38801885
Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2., PMID:38370406
The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses., PMID:38077328
Identification of alternative splicing associated with clinical features: from pan-cancers to genitourinary tumors., PMID:37810965
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries., PMID:37156999
The gender-specific bidirectional relations between chronic diseases and total bilirubin/urea in the elderly population: A 3-year longitudinal study., PMID:36438212
Novel actionable ROS1::GIT2 fusion in non-Langerhans cell histiocytosis with central nervous system involvement., PMID:36416966
CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation., PMID:36244799
In Vitro Insertional Mutagenesis Screen Identifies Novel Genes Driving Breast Cancer Metastasis., PMID:35687718
Effect of Monoacylglycerol Lipase Inhibition on Intestinal Permeability of Rats With Severe Acute Pancreatitis., PMID:35496266
The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease., PMID:35457203
Long non-coding RNA MALAT1 promotes odontogenic differentiation of human dental pulp stem cells by impairing microRNA-140-5p-dependent downregulation of GIT2., PMID:32743695
A genome wide association study for lung function in the Korean population using an exome array., PMID:32336055
Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma., PMID:32164487
G Protein-Coupled Receptor Systems and Their Role in Cellular Senescence., PMID:31921393
The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage., PMID:31794429
Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories., PMID:31574270
GIT2 deficiency attenuates inflammation-induced expression of pro-labor mediators in human amnion and myometrial cells†., PMID:30915469
Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality., PMID:30439596
Mesenchymal glioblastoma constitutes a major ceRNA signature in the TGF-β pathway., PMID:30279734
G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes., PMID:30261591
Identification of six novel susceptibility loci for dyslipidemia using longitudinal exome-wide association studies in a Japanese population., PMID:29879492
Discovery of 4 exonic and 1 intergenic novel susceptibility loci for leprosy., PMID:29722023
GIT2-A keystone in ageing and age-related disease., PMID:29452267
Mesenchymal stem cells promote endothelial progenitor cell migration, vascularization, and bone repair in tissue-engineered constructs via activating CXCR2-Src-PKL/Vav2-Rac1., PMID:29229683
Requirement of Treg-intrinsic CTLA4/PKCη signaling pathway for suppressing tumor immunity., PMID:29212947
A novel GIT2-BRAF fusion in pilocytic astrocytoma., PMID:29141672
ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis., PMID:28969640
[High-Content siRNA Screen of the Kinome Identifies Kinases Involved in Git2-Induced Mesenchymal-Epithelial Transition]., PMID:28900089
Genetic deletion of GIT2 prolongs functional recovery and suppresses chondrocyte differentiation in rats with rheumatoid arthritis., PMID:28777475
The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b., PMID:28611183
Arf GAPs: A family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex., PMID:28362242
Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay., PMID:28341739
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption., PMID:28260693
Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia., PMID:28117656
Emerging Role for RBM20 and its Splicing Substrates in Cardiac Function and Heart Failure., PMID:27396593
The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion., PMID:27669437
Antiviral Activity of a Novel Compound CW-33 against Japanese Encephalitis Virus through Inhibiting Intracellular Calcium Overload., PMID:27563890
[Effect of GTPase activating protein Git2 on metastasis in breast cancer]., PMID:27531261
EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration., PMID:27238570
Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes., PMID:27182061
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging., PMID:26834700
Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse., PMID:26637799
Gene expression profile in breast cancer comprising predictive markers for metastatic risk., PMID:26400320
GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice., PMID:26380813
For research use only. Not for human or drug use.
