Catalog No.
YMG54401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Thr37-Ala126
Predicted molecular weight
38.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9EQD0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Frizzled-5, FzE5, C2orf31, hFz5, FZD5, Fz-5
WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling., PMID:40413190
frizzled 5 mutant zebrafish are genetically sensitised to developing microphthalmia and coloboma., PMID:40401611
Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors., PMID:40307870
Identification of Wnt-5a Receptors Important in Diabetic and Non-Diabetic Corneal Epithelial Wound Healing., PMID:39998459
Cancer-associated fibroblasts promote growth and dissemination of esophageal squamous cell carcinoma cells by secreting WNT family member 5A., PMID:39954174
A pilot study of transcriptomic preimplantation genetic testing (PGT-T): towards a new step in embryo selection?, PMID:39719045
Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation., PMID:39627337
Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy., PMID:39602462
Frizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility., PMID:39579769
FZD5 controls intestinal crypt homeostasis and colonic Wnt surrogate agonist response., PMID:39579768
Homozygosity for a hypomorphic mutation in frizzled class receptor 5 causes syndromic ocular coloboma with microcornea in humans., PMID:39503780
Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL., PMID:39463927
A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis., PMID:38980870
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors., PMID:38969364
circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis., PMID:38780005
Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis., PMID:38694033
Integrative ATAC-seq and RNA-seq analysis of myogenic differentiation of ovine skeletal muscle satellite cell., PMID:38692440
Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1., PMID:38539211
Pinoresinol diglucoside mitigates dexamethasone-induced osteoporosis and chondrodysplasia in zebrafish., PMID:38442791
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification., PMID:38358799
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma Based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing., PMID:38299418
Compound heterozygous WNT10A missense variations exacerbated the tooth agenesis caused by hypohidrotic ectodermal dysplasia., PMID:38280992
Age and light damage influence Fzd5 regulation of ocular growth-related genes., PMID:38154732
Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy., PMID:38101654
Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells., PMID:37951508
Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids., PMID:37917586
IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion., PMID:37906644
Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS., PMID:37766984
Insilco prediction of the role of the FriZZled5 gene in colorectal cancer., PMID:37595345
Axonal transport of Frizzled5 by Alcadein α-containing vesicles is associated with kinesin-1., PMID:37585286
A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis., PMID:37577522
Ehrlichia Wnt SLiM ligand mimic deactivates the Hippo pathway to engage the anti-apoptotic Yap-GLUT1-BCL-xL axis., PMID:37530530
Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations., PMID:37516754
The impaired swim bladder via ROS-mediated inhibition of the Wnt / Hedgehog pathway in zebrafish embryos exposed to eight toxic chemicals and binary chemical mixtures., PMID:37478986
Targeted alveolar regeneration with Frizzled-specific agonists., PMID:37321220
β-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1β Signalosome in Aeromonas hydrophila-Infected Zebrafish Macrophages., PMID:37296630
A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA., PMID:37095549
WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction., PMID:37014927
Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV)., PMID:36867129
Individuals with heterozygous variants in the Wnt-signalling pathway gene FZD5 delineate a phenotype characterized by isolated coloboma and variable expressivity., PMID:36695497
Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly., PMID:36342472
Spatiotemporal distribution analyses of Wnt5a ligand and its receptors Ror2, Frizzled2, and Frizzled5 during tongue muscle development in prenatal mice., PMID:36280189
Wnt 5a mediated inflammatory injury of renal tubular epithelial cells dependent on calcium signaling pathway in Trichloroethylene sensitized mice., PMID:36030685
Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth., PMID:35975457
LncRNA FGD5-AS1 drives the malignant development of gastric cancer by negatively interacting with FZD3., PMID:35848483
cRel and Wnt5a/Frizzled 5 Receptor-Mediated Inflammatory Regulation Reveal Novel Neuroprotectin D1 Targets for Neuroprotection., PMID:35622188
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling., PMID:35569814
RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface., PMID:35487932
Barrett's Metaplasia Progression towards Esophageal Adenocarcinoma: An Attempt to Select a Panel of Molecular Sensors and to Reflect Clinical Alterations by Experimental Models., PMID:35328735
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters., PMID:35296808
For research use only. Not for human or drug use.
