Catalog No.
YMK86001
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gln44-Lys189
Predicted molecular weight
18.34 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5NCP0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase RNF43, RING finger protein 43, RING-type E3 ubiquitin transferase RNF43, RNF43
LncRNA MIR503HG regulates NETs-mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ., PMID:40490947
The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma., PMID:40264052
Qingre Huayu Jianpi decoction suppresses colorectal tumorigenesis by inhibiting cancer stem cells and cancer-associated fibroblasts., PMID:40220938
Whole genome sequencing of 378 prostate cancer metastases reveals tissue selectivity for mismatch deficiency with potential therapeutic implications., PMID:40114169
Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs., PMID:40000409
[NTRK gene fusion and molecular pathological characteristics of mismatch repair deficient colorectal cancer]., PMID:39863528
Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma., PMID:39851951
Identification of clinicopathological-specific driver gene and genetic subtyping of colorectal cancer., PMID:39797621
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling., PMID:39753551
Comprehensive characterization of MCL-1 in patients with colorectal cancer: Expression, molecular profiles, and outcomes., PMID:39740007
Stem Cell Markers LGR5, LGR4 and Their Immediate Signalling Partners are Dysregulated in Preeclampsia., PMID:39688759
Lack of dominant-negative activity for tumor-related ZNRF3 missense mutations at endogenous levels., PMID:39674817
Gender-based differences in the efficacy of anti-EGFR/BRAF/MEK targeted therapy in patients with BRAF-mutated metastatic colorectal cancer., PMID:39627078
RNF43 and ZNRF3: Versatile regulators at the membrane and their role in cancer., PMID:39551397
Germline pathogenic variants in RNF43 in patients with and without serrated polyposis syndrome., PMID:39546056
Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome., PMID:39519399
Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL., PMID:39463927
RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells., PMID:39432578
Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre study., PMID:39383608
Efficacy of durvalumab plus chemotherapy in advanced biliary duct cancer and biomarkers exploration., PMID:39235609
An "R-spondin code" for multimodal signaling ON-OFF states., PMID:39180250
RNF43 in cancer: Molecular understanding and clinical significance in immunotherapy., PMID:39146560
Duodenal Fluid Analysis as a Rewarding Approach to Detect Low-Abundance Mutations in Biliopancreatic Cancers., PMID:39126005
New Target(s) for RNF43 Regulation: Implications for Therapeutic Strategies., PMID:39125653
Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes., PMID:39120161
QPH-FR: A Novel Quinoa Peptide Enhances Chemosensitivity by Targeting Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Colorectal Cancer., PMID:39047262
Molecular pathogenesis of microsatellite instability-high early-stage colorectal adenocarcinoma in India., PMID:39042905
Protein and mRNA Expression in Uveal Melanoma Cell Lines Are Related to GNA and BAP1 Mutation Status., PMID:39042403
Validation of a targeted next-generation sequencing panel for pancreatic ductal adenocarcinomas., PMID:39033589
Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer., PMID:39019980
m6A methylation of RNF43 inhibits the progression of endometriosis through regulating oxidative phosphorylation via NDUFS1., PMID:38988031
Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer., PMID:38982444
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled receptors., PMID:38969364
Characterization of Wnt Signaling Pathway Aberrations in Metastatic Prostate Cancer., PMID:38912907
Associations with other cancer-related biomarkers might contribute to poor outcomes in RAS-altered, younger patients with colorectal cancer., PMID:38886182
Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling., PMID:38855175
Targeted protein degradation systems to enhance Wnt signaling., PMID:38847394
Molecular characteristics of early-onset compared with late-onset colorectal cancer: a case controlled study., PMID:38742845
Lactobacillus rhamnosus GG Stimulates Dietary Tryptophan-Dependent Production of Barrier-Protecting Methylnicotinamide., PMID:38641207
Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer., PMID:38622664
Gastric Carcinoma in Autoimmune Gastritis: A Histopathologic and Molecular Study., PMID:38588886
Recurrent mutations in tumor suppressor FBXW7 bypass Wnt/β-catenin addiction in cancer., PMID:38569029
NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study., PMID:38551383
Ring Finger 43 Hot-spot Frameshift Mutation G659V in Colorectal Cancer Patients: Report from a Tertiary Cancer Care Hospital in North India., PMID:38504846
Mucin phenotype and genetic alterations in non-V600E BRAF-mutated colorectal cancer., PMID:38423222
Role of IFITM2 in osteogenic differentiation of C3H10T1/2 mesenchymal stem cells., PMID:38404731
Association of RNF43 Genetic Alterations With BRAFV600E and MSIhigh in Colorectal Cancer., PMID:38394466
New insights in ubiquitin-dependent Wnt receptor regulation in tumorigenesis., PMID:38383910
Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma., PMID:38281914
Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer., PMID:38260423
For research use only. Not for human or drug use.
