Catalog No.
YHD00901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly303
Predicted molecular weight
37.79 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2R2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTPN8, Lymphoid phosphatase, PTPN22, PEST-domain phosphatase, LyP, Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PEP
Triple positivity for autoantibodies in patients with rheumatoid arthritis is associated with a severe course of the disease but not with bone turnover markers., PMID:40485950
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis., PMID:40349959
Persea americana Peel: A Promising Source of Nutraceutical for the Mitigation of Cardiovascular Risk in Arthritic Rats Through the Gut-Joint Axis., PMID:40305360
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia., PMID:40299016
1H, 13C and 15N backbone resonance assignment of the catalytic domain of human PTPN22., PMID:40281380
The Association between PTPN22 SNPs and susceptibility to type 1 diabetes: An updated meta-analysis., PMID:40238817
Graves' Disease: Is It Time for Targeted Therapy? A Narrative Review., PMID:40142311
Using genetics, genomics, and transcriptomics to identify therapeutic targets in juvenile idiopathic arthritis., PMID:40083163
Deciphering autoimmune susceptibility: a meta-analysis of PTPN22 gene variants., PMID:40067478
Protein phosphatases in systemic autoimmunity., PMID:39944077
STAT4 gene polymorphism may be associated with microscopic polyangiitis susceptibility in a Chinese Guangxi population: A case-control analysis based on propensity score matching., PMID:39862807
Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis., PMID:39741066
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis., PMID:39724988
Structure-activity relationship studies and design of a PTPN22 inhibitor with enhanced isozyme selectivity and cellular efficacy., PMID:39693863
Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa., PMID:39682729
PTPN22 and the pathogenesis of ulcerative colitis: Insights into T cell differentiation and the JAK/STAT signaling pathway., PMID:39643025
Systematic literature review on early clinical evidence for immune-resolution therapies and potential benefits to patients and healthcare providers., PMID:39483464
Dendritic cell-intrinsic PTPN22 negatively regulates antitumor immunity and impacts anti-PD-L1 efficacy., PMID:39461876
ASIA Syndrome: State-of-the-Art and Future Perspectives., PMID:39460349
Quercetin as a Modulator of PTPN22 Phosphomonoesterase Activity: A Biochemical and Computational Evaluation., PMID:39451542
Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population., PMID:39425874
Genetics, epigenetics and autoimmunity constitute a Bermuda triangle for the pathogenesis of rheumatoid arthritis., PMID:39341491
Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression., PMID:39227386
Role of Selected Genetic Polymorphisms in the Development of Rheumatoid Arthritis in a British White Population., PMID:39202369
A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans., PMID:39173071
Study of the Immune Infiltration and Sonic Hedgehog Expression Mechanism in Synovial Tissue of Rheumatoid Arthritis-Related Interstitial Lung Disease under Machine Learning CIBERSORT Algorithm., PMID:39110383
PTPN22 through the regulation of Th17/Treg balance acts as a potential target for the treatment of Graves' disease., PMID:39083881
Regulation of T Cell Signaling and Immune Responses by PTPN22., PMID:39039893
The Role of the Immune System in the Course of Hashimoto's Thyroiditis: The Current State of Knowledge., PMID:38999993
Targeting cathepsin C ameliorates murine acetaminophen-induced liver injury., PMID:38855187
DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease., PMID:38782200
A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling., PMID:38777143
Study of Association of Chromosomal Region 1Q21-23 with Rheumatoid Arthritis and Their Correlation with Severity of Disease., PMID:38700298
A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans., PMID:38559252
Machine learning-based prediction of rheumatoid arthritis with development of ACPA autoantibodies in the presence of non-HLA genes polymorphisms., PMID:38517871
Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity., PMID:38512979
Shared and distinct genetics of pure type 1 diabetes and type 1 diabetes with celiac disease, homology in their auto-antigens and immune dysregulation states: a study from North India., PMID:38483572
A multi-ancestry genome-wide association study in type 1 diabetes., PMID:38453145
Genotypes predisposing for celiac disease and autoimmune diabetes and risk of infections in early childhood., PMID:38374560
Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis., PMID:38368726
[Predictive significance of genetic analysis of the development of dry eye disease of different origin]., PMID:38235625
OT-I TCR Transgenic Mice to Study the Role of PTPN22 in Anti-cancer Immunity., PMID:38147209
Increased expression of protein tyrosine phosphatase nonreceptor type 22 alters early T-cell receptor signaling and differentiation of CD4+ T cells in chronic heart failure., PMID:38112398
The genetics of Graves' disease., PMID:38108994
Analysis of IL-1β, TGF-β, IL-5, ACE, PTPN22 gene polymorphisms, and gene expression levels in Turkish children with IgA vasculitis., PMID:38085361
Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion., PMID:38056892
Small molecule inhibitors for cancer immunotherapy and associated biomarkers - the current status., PMID:38022587
Deletion of Vβ3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells., PMID:38015847
Relationship between the Ubiquitin-Proteasome System and Autophagy in Colorectal Cancer Tissue., PMID:38002011