Catalog No.
YHN35301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
His136-Gly454
Predicted molecular weight
37.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKT8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein MD6, F-box and WD-40 domain-containing protein 2, FBXW2, FBW2, F-box/WD repeat-containing protein 2, FWD2
LINC00908 Inactivates Wnt/β-Catenin Signaling Pathway to Inhibit Prostate Cancer Cell Stemness via Upregulating GSK3B and FBXW2., PMID:40344383
FBXW2 inhibits the progression of gastric cancer via promoting β-catenin ubiquitylation., PMID:40225854
Expression of Elastin, F-Box and WD-40 Domain-Containing Protein 2, Fibrillin-1, and Alpha-Smooth Muscle Actin in Utilized Blood Vessels for explant culture-A New 3D in Vitro Vascular Model from Bovine Legs., PMID:39731648
Activated Clec4nhi Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner., PMID:38574235
FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis., PMID:37736741
Elastic Fibers and F-Box and WD-40 Domain-Containing Protein 2 in Bovine Periosteum and Blood Vessels., PMID:36648793
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation., PMID:35499593
Role of FBXW2 in explant cultures of bovine periosteum-derived cells., PMID:34736516
Ubiquitination of NF-κB p65 by FBXW2 suppresses breast cancer stemness, tumorigenesis, and paclitaxel resistance., PMID:34465889
USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates., PMID:34425107
TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance., PMID:33962073
Transthyretin affects the proliferation and migration of human retinal microvascular endothelial cells in hyperglycemia via hnRNPA2B1., PMID:33894415
E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis., PMID:33101872
Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action., PMID:33091855
Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia., PMID:33029266
Gartanin is a novel NEDDylation inhibitor for induction of Skp2 degradation, FBXW2 expression, and autophagy., PMID:31782573
The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells., PMID:31548378
Computational identification and analysis of early diagnostic biomarkers for kidney cancer., PMID:31350524
FBXW2 suppresses proliferation and invasion of lung cancer cells by targeting SKP2 and β-catenin., PMID:31211237
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation., PMID:30918250
Identification of reference genes for quantitative PCR during C3H10T1/2 chondrogenic differentiation., PMID:30847849
Characterization of the F-box Proteins FBXW2 and FBXL14 in the Initiation of Bone Regeneration in Transplants given to Nude Mice., PMID:30450135
FBXW2 localizes with osteocalcin in bovine periosteum on culture dishes as visualized by double immunostaining., PMID:30229138
The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor., PMID:28090088
RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion., PMID:23651062
Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation., PMID:18703417
A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2., PMID:18648537
FBW2 targets GCMa to the ubiquitin-proteasome degradation system., PMID:15640526
Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10., PMID:11735228
Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors., PMID:10828603
Structure and expression of the gene encoding mouse F-box protein, Fwd2., PMID:10585767
For research use only. Not for human or drug use.
