Catalog No.
YHN35001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu4347-Glu4446
Predicted molecular weight
13.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UFH2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNAHL1, Ciliary dynein heavy chain 17, Axonemal dynein heavy chain-like protein 1, Ciliary dynein heavy chain-like protein 1, Dynein light chain 2, axonemal, DNAH17, Axonemal beta dynein heavy chain 17, DNEL2, Dynein heavy chain 17, axonemal
Novel variants in DNAH17 cause sperm flagellar outer dynein arm defects but not total fertilization failure after ICSI., PMID:40009974
Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice., PMID:39245651
Genetic change investigation in DOCK1 gene in an Iranian family with sign and symptoms of temporomandibular joint disorder (TMD)., PMID:39020145
A novel homozygous missense TTC12 variant identified in an infertile Pakistani man with severe oligoasthenoteratozoospermia and primary ciliary dyskinesia., PMID:38992144
Identification of high-risk non-synonymous SNPs (nsSNPs) in DNAH1 and DNAH17 genes associated with male infertility: a bioinformatics analysis., PMID:38874855
A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy., PMID:38858421
Systematic molecular analyses for 115 karyotypically normal men with isolated non-obstructive azoospermia., PMID:38511217
Impact of Genomic Alterations on the Clinical Outcome of Patients With Hepatitis B-related Hepatocellular Carcinoma Receiving Curative Surgery: A Retrospective Cohort Study., PMID:37772577
Designing of neoepitopes based vaccine against breast cancer using integrated immuno and bioinformatics approach., PMID:37584493
Novel mutations in DNAH17 cause sperm flagellum defects and their influence on ICSI outcome., PMID:37574497
Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway., PMID:37001189
Population-based genetic analysis in infertile men reveals novel mutations of ADAD family members in patients with impaired spermatogenesis., PMID:36708028
Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection., PMID:36589837
A novel homozygous frameshift variant in DNAH8 causes multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family., PMID:36308074
Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility., PMID:36048845
Novel compound heterozygous variants of DNAH17 in a Chinese infertile man with multiple morphological abnormalities of sperm flagella., PMID:35932098
Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes., PMID:35484513
Exome sequencing in individuals with cardiovascular laterality defects identifies potential candidate genes., PMID:35474353
Identification of Potential Biological Factors Affecting the Treatment of Ticagrelor After Percutaneous Coronary Intervention in the Chinese Population., PMID:35082514
A novel mutation in DNAH17 is present in a patient with multiple morphological abnormalities of the flagella., PMID:34373205
Novel DNAH17 mutations associated with fertilization failures after ICSI., PMID:34126833
DNAH17 is essential for rat spermatogenesis and fertility., PMID:33764336
Infertility due to defective sperm flagella caused by an intronic deletion in DNAH17 that perturbs splicing., PMID:33724408
Novel compound heterozygous variants in dynein axonemal heavy chain 17 cause asthenoteratospermia with sperm flagellar defects., PMID:33423959
Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player., PMID:33108537
Comprehensive Analysis of RNA-Seq Gene Expression Profiling of Brain Transcriptomes Reveals Novel Genes, Regulators, and Pathways in Autism Spectrum Disorder., PMID:33080834
Novel loss-of-function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice., PMID:33070343
Long noncoding RNA DNAH17-AS1 promotes tumorigenesis and metastasis of non-small cell lung cancer via regulating miR-877-5p/CCNA2 pathway., PMID:32981678
Clustering by phenotype and genome-wide association study in autism., PMID:32807774
Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility., PMID:32619401
DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p., PMID:32351291
Exome sequencing reveals novel causes as well as new candidate genes for human globozoospermia., PMID:31985809
DNAH17 is associated with asthenozoospermia and multiple morphological abnormalities of sperm flagella., PMID:31841227
A DNAH17 missense variant causes flagella destabilization and asthenozoospermia., PMID:31658987
Integrated bioinformatics analysis revealing independent prognostic long non-coding RNAs DNAH17-AS1 and RP11-400N13.2 and their potential oncogenic roles in colorectal cancer., PMID:31516583
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia., PMID:31178125
Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation., PMID:30721949
The association between methylation patterns of DNAH17 and clinicopathological factors in hepatocellular carcinoma., PMID:30575322
Undifferentiated embryonal sarcoma of the liver in a child: A whole exome sequencing analysis., PMID:28539230
A potential human axonemal dynein heavy-chain gene maps to 17q25., PMID:9545504
For research use only. Not for human or drug use.
