Catalog No.
YHN34401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr95-Asp175
Predicted molecular weight
21.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NXW2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNAJB12, DnaJ homolog subfamily B member 12
Orthologues of the human protein histidine methyltransferase METTL9 display distinct substrate specificities., PMID:40451431
Cytosolic and endoplasmic reticulum chaperones inhibit wt-p53 to increase cancer cells' survival by refluxing ER-proteins to the cytosol., PMID:40202782
Mendelian randomization analysis to identify potential drug targets for osteoarthritis., PMID:39932908
Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause., PMID:38184718
DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein reflux., PMID:37925033
Novel functions of the ER-located Hsp40s DNAJB12 and DNAJB14 on proteins at the outer mitochondrial membrane under stress mediated by CCCP., PMID:37851175
DNAJB12 and Hsp70 Mediate Triage of Misfolded Membrane Proteins for Proteasomal versus Lysosomal Degradation., PMID:36743458
Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood., PMID:36352383
Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin., PMID:35704470
Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens., PMID:35082301
Proteomic Insights Into Susceptibility and Resistance to Chronic-Stress-Induced Depression or Anxiety in the Rat Striatum., PMID:34676246
A plant reovirus hijacks the DNAJB12-Hsc70 chaperone complex to promote viral spread in its planthopper vector., PMID:34668642
DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy., PMID:33534640
HNF1A-Induced lncRNA HCG18 Facilitates Gastric Cancer Progression by Upregulating DNAJB12 via miR-152-3p., PMID:32801777
Analyses of the function of DnaJ family proteins reveal an underlying regulatory mechanism of heat tolerance in honeybee., PMID:32059293
Environmental Stress Responses of DnaJA1, DnaJB12 and DnaJC8 in Apis cerana cerana., PMID:30349556
A Systematic Study of PLLA Aligned Nanofiber-Induced Differentiation of PC12 Cells Using mRNA-microRNAProtein Biomics Integrated Analyses., PMID:31251138
Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis., PMID:28536268
Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins., PMID:27916661
Identification of Genes Whose Expression Profile Is Associated with Non-Progression towards AIDS Using eQTLs., PMID:26367535
Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure., PMID:24732912
A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum., PMID:24675744
A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins., PMID:23018488
A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR., PMID:21150129
The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508., PMID:21148293
Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS., PMID:19496026
Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature., PMID:11147971
For research use only. Not for human or drug use.
