Catalog No.
YHN34201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala2-Pro71
Predicted molecular weight
36.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NX52
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTF, NTF, RRP2, Rhomboid-related protein 2, Rhomboid-like protein 2, RHBDL2
Knockdown of CCNB2 inhibits the tumorigenesis of gastric cancer by regulation of the PI3K/Akt pathway., PMID:39962178
Rhomboid-like 2 correlated with TME infiltration inhibits cuproptosis-related genes and drives malignant phenotype in clear cell renal cell carcinoma., PMID:39511359
RHBDL2 promotes the proliferation, migration, and invasion of pancreatic cancer by stabilizing the N1ICD via the OTUD7B and activating the Notch signaling pathway., PMID:36351890
Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation., PMID:34800360
The role of proteolysis in interleukin-11 signaling., PMID:34624437
Association of human breast cancer CD44-/CD24- cells with delayed distant metastasis., PMID:34318746
Novel predictive biomarkers for acute injury superimposed on chronic kidney disease., PMID:36165377
Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling., PMID:33566379
Novel predictive biomarkers for acute injury superimposed on chronic kidney disease., PMID:33158604
Structural cavities are critical to balancing stability and activity of a membrane-integral enzyme., PMID:32848056
Thrombomodulin Functional Domains Support Osteoblast Differentiation and Bone Healing in Diabetes in Mice., PMID:32329910
Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations., PMID:32246901
Rhomboid-Like-2 Intramembrane Protease Mediates Metalloprotease-Independent Regulation of Cadherins., PMID:31783481
Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation., PMID:30866526
Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis., PMID:28779096
Probing the Activity of Eukaryotic Rhomboid Proteases In Vitro., PMID:28065274
Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2)., PMID:26939791
RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells., PMID:24977233
Rhomboid family gene expression profiling in breast normal tissue and tumor samples., PMID:24185965
Emerging role of rhomboid family proteins in mammalian biology and disease., PMID:23562403
Rhomboid proteins: a role in keratinocyte proliferation and cancer., PMID:23263464
Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics., PMID:23150798
RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome., PMID:22265016
Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing., PMID:21833011
Multiple Loci modulate opioid therapy response for cancer pain., PMID:21622719
Mammalian EGF receptor activation by the rhomboid protease RHBDL2., PMID:21494248
The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity., PMID:19850051
Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2., PMID:15047175
Diverse substrate recognition mechanisms for rhomboids; thrombomodulin is cleaved by Mammalian rhomboids., PMID:14761657
For research use only. Not for human or drug use.
