Catalog No.
YHJ99502
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val65-Gln108
Predicted molecular weight
33.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRA2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
H(+)/sialic acid cotransporter, H(+)/nitrate cotransporter, Sialin, AST, Vesicular H(+)/Aspartate-glutamate cotransporter, SLC17A5, Membrane glycoprotein HP59, Solute carrier family 17 member 5
Inorganic nitrate attenuates neuroinflammation after traumatic brain injury via Sialin., PMID:40373612
Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy., PMID:40290421
Atypical free sialic acid storage disorder associated with tissue specific mosaicism of SLC17A5., PMID:39742826
Generation and characterization of two iPSC lines derived from subjects with Free Sialic Acid Storage Disorder (FSASD)., PMID:39461116
Dietary nitrate maintains intestinal epithelia homeostasis in aged mice., PMID:39162978
Inflammation-induced sialin mediates nitrate efflux in dysfunctional endothelium affecting NO bioavailability., PMID:38579899
Transcriptomic analysis following polystyrene nanoplastic stress in the Pacific white shrimp, Litopenaeus vannamei., PMID:37923183
Base editing corrects the common Salla disease SLC17A5 c.115C>T variant., PMID:37727271
Teaching NeuroImage: A New Imaging Finding in a Boy With Salla Disease Caused by a Pathogenic Variant in the SLC17A5 Gene., PMID:37527937
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity., PMID:37200393
A Palindrome-Like Structure on 16p13.3 Is Associated with the Formation of Complex Structural Variations and SRRM2 Haploinsufficiency., PMID:40225164
A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis., PMID:37023829
The molecular mechanism of sialic acid transport mediated by Sialin., PMID:36662855
Free urinary sialic acid levels may be elevated in patients with pneumococcal sepsis., PMID:36000484
Unclassified white matter disorders: A diagnostic journey requiring close collaboration between clinical and laboratory services., PMID:35803560
Effect of activation of liver X receptor alpha on cardiac & hepatic ABCC10 and SLC17A5 drug transporters in hypercholesterolemic rat model., PMID:35462094
A bibliometric review of peripartum cardiomyopathy compared to other cardiomyopathies using artificial intelligence and machine learning., PMID:35340600
Implementation of fetal clinical exome sequencing: Comparing prospective and retrospective cohorts., PMID:34906519
SLC gene mutations and pediatric neurological disorders: diverse clinical phenotypes in a Saudi Arabian population., PMID:34797406
Free sialic acid storage disorder: Progress and promise., PMID:33862140
Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome., PMID:33557955
Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin., PMID:32608236
Genome-wide analysis of MicroRNA-messenger RNA interactome in ex-vivo gill filaments, Anguilla japonica., PMID:32131732
Linkage and exome analysis implicate multiple genes in non-syndromic intellectual disability in a large Swedish family., PMID:31694657
Hypogammaglobulinemia and imaging features in a patient with infantile free sialic acid storage disease (ISSD) and a novel mutation in the SLC17A5 gene., PMID:30243016
[Bioinformatics analysis of genes related to pathogenesis of major depression disorder]., PMID:30112561
Biochemical and molecular analyses of infantile sialic acid storage disease in a patient with nonimmune hydrops fetalis., PMID:29654786
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease., PMID:29140481
A New Patient With Intermediate Severe Salla Disease With Hypomyelination: A Literature Review for Salla Disease., PMID:28662915
Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice., PMID:28189729
Identification of a large intronic transposal insertion in SLC17A5 causing sialic acid storage disease., PMID:28187749
Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells., PMID:26428916
The early detection of Salla disease through second-tier tests in newborn screening: how to face incidental findings., PMID:24993898
Vesicular uptake of N-acetylaspartylglutamate is catalysed by sialin (SLC17A5)., PMID:23889254
Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane., PMID:22778404
Successful prediction of substrate-binding pocket in SLC17 transporter sialin., PMID:22334707
Functional characterization of vesicular excitatory amino acid transport by human sialin., PMID:21781115
Prenatal screening of sialic acid storage disease and confirmation in cultured fibroblasts by LC-MS/MS., PMID:21617927
Elevated CSF N-acetylaspartylglutamate suggests specific molecular diagnostic abnormalities in patients with white matter diseases., PMID:20637281
Elevated CSF N-acetylaspartylglutamate in patients with free sialic acid storage diseases., PMID:20101035
Glutamate, aspartate and nucleotide transporters in the SLC17 family form four main phylogenetic clusters: evolution and tissue expression., PMID:20059771
Free sialic acid storage disease without sialuria., PMID:19557856
Sodium butyrate alters erythropoietin glycosylation via multiple mechanisms., PMID:17570711
Prenatal diagnosis of free sialic acid storage disorders (SASD)., PMID:16715535
Novel form of intermediate salla disease: clinical and neuroimaging features., PMID:16417876
Homozygosity for the p.K136E mutation in the SLC17A5 gene as cause of an Italian severe Salla disease., PMID:16170568
Genome-wide SNP arrays as a diagnostic tool: clinical description, genetic mapping, and molecular characterization of Salla disease in an Old Order Mennonite population., PMID:16158439
Sialin, an anion transporter defective in sialic acid storage diseases, shows highly variable expression in adult mouse brain, and is developmentally regulated., PMID:16023578
A novel mutation in the SLC17A5 gene causing both severe and mild phenotypes of free sialic acid storage disease in one inbred Bedouin kindred., PMID:15172005
For research use only. Not for human or drug use.
