Catalog No.
YHN33301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser76-Gln421
Predicted molecular weight
41.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HBH9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAP kinase-interacting serine/threonine-protein kinase 2, MAPK signal-integrating kinase 2, GPRK7, MNK2, MKNK2, Mnk2, MAP kinase signal-integrating kinase 2
The MNK-SYNGAP1 axis in specific learning disorder: gene expression pattern and new perspectives., PMID:40108041
Morpholino nicotinamide analogs of ponatinib, dual MNK, p70S6K inhibitors, display efficacy against lung and breast cancers., PMID:40081260
RALYL Overexpression Suppresses Colorectal Cancer via Modulating HNRNPC-Mediated MNK2 Alternative Splicing., PMID:40052233
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia., PMID:40033556
Stress Response Kinase MK2 Induces Non-canonical Activation of EphA2 in EML4-ALK Lung Cancer Cells., PMID:40024717
JNK Inhibition Overcomes Resistance of Metastatic Tetraploid Cancer Cells to Irradiation-Induced Apoptosis., PMID:39940976
Phase Ib Pharmacodynamic Study of the MNK Inhibitor Tomivosertib (eFT508) Combined With Paclitaxel in Patients With Refractory Metastatic Breast Cancer., PMID:39576211
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2., PMID:39508235
MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction., PMID:39145446
RBM25 depletion suppresses the growth of colon cancer cells through regulating alternative splicing of MNK2., PMID:39110401
Novel gene fusions in human oropharyngeal carcinoma., PMID:38971117
Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d]pyrimidine derivatives as Mnk1/2 inhibitors., PMID:38759457
Design, synthesis and biological evaluation of MNK-PROTACs., PMID:38498082
High Expression of miR-6785-5p in the Serum Exosomes of Psoriasis Patients Alleviates Psoriasis-Like Skin Damage by Interfering with the MNK2/p-eIF4E Axis in Keratinocytes., PMID:38472599
Identification of SGMS2 as a molecule involved in natural killer cell recruitment and its in-deep analysis in the liver cancer microenvironment: Evidence from large populations cohort., PMID:37849429
Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation., PMID:37669313
Integrated analysis of the lncRNA-associated ceRNA network in Alzheimer's disease., PMID:37187245
Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation., PMID:36778430
MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion., PMID:36764601
MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion., PMID:36711529
Exosomes Released by Influenza-Virus-Infected Cells Carry Factors Capable of Suppressing Immune Defense Genes in Naïve Cells., PMID:36560694
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1., PMID:36315645
Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy., PMID:36209049
Novel AR/AR-V7 and Mnk1/2 Degrader, VNPP433-3β: Molecular Mechanisms of Action and Efficacy in AR-Overexpressing Castration Resistant Prostate Cancer In Vitro and In Vivo Models., PMID:36078112
Research on the Mechanism of HRP Relieving IPEC-J2 Cells Immunological Stress Based on Transcriptome Sequencing Analysis., PMID:35911118
Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK/ERK signaling., PMID:35715841
Novel deuterated Mnk1/2 protein degrader VNLG-152R analogs: Synthesis, In vitro Anti-TNBC activities and pharmacokinetics in mice., PMID:35617854
MiR-223-3p alleviates trigeminal neuropathic pain in the male mouse by targeting MKNK2 and MAPK/ERK signaling., PMID:35608154
MNK2-eIF4E axis promotes cardiac repair in the infarcted mouse heart by activating cyclin D1., PMID:35235835
Identification of a dual FLT3 and MNK2 inhibitor for acute myeloid leukemia treatment using a structure-based virtual screening approach., PMID:35182882
Multi-Target In Silico Prediction of Inhibitors for Mitogen-Activated Protein Kinase-Interacting Kinases., PMID:34827668
Update on the Development of MNK Inhibitors as Therapeutic Agents., PMID:34533957
Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth., PMID:34515481
MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b., PMID:33836345
Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses., PMID:33690225
MNK as a potential pharmacological target for suppressing LPS-induced acute lung injury in mice., PMID:33675774
SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma., PMID:33602301
MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma., PMID:33564073
ONC201 Shows Potent Anticancer Activity Against Medullary Thyroid Cancer via Transcriptional Inhibition of RET, VEGFR2, and IGFBP2., PMID:33536187
Mnk inhibitors: a patent review., PMID:33441033
Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock., PMID:33303237
MNK2 governs the macrophage antiinflammatory phenotype., PMID:33077599
[Effect of NUDT21 on Alternative Splicing of Transcripts in K562 Cells]., PMID:33067945
Design, Synthesis and Bioactivity Evaluation of 4,6-Disubstituted Pyrido[3,2-d]pyrimidine Derivatives as Mnk and HDAC Inhibitors., PMID:32967084
Preclinical evidence that MNK/eIF4E inhibition by cercosporamide enhances the response to antiangiogenic TKI and mTOR inhibitor in renal cell carcinoma., PMID:32828276
Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ and MAP kinase-interacting kinases during early adipogenesis., PMID:32787498
Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity., PMID:32712434
MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity., PMID:32648926
IL-6 induced upregulation of T-type Ca2+ currents and sensitization of DRG nociceptors is attenuated by MNK inhibition., PMID:32519575
The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma., PMID:32517051
For research use only. Not for human or drug use.
