Catalog No.
YHN32201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile483-Thr688
Predicted molecular weight
24.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BQ52
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Heredity prostate cancer protein 2, Zinc phosphodiesterase ELAC protein 2, ElaC homolog protein 2, HPC2, Ribonuclease Z 2, ELAC2, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z 2
Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA., PMID:39973625
Advances in Human Pre-tRNA Maturation: TRMT10C and ELAC2 in Focus., PMID:39938738
Molecular basis of human nuclear and mitochondrial tRNA 3' processing., PMID:39747487
Targeting mitochondrial RNAs enhances the efficacy of the DNA-demethylating agents., PMID:39730484
Structural basis of 3'-tRNA maturation by the human mitochondrial RNase Z complex., PMID:39516281
Structural insights into human ELAC2 as a tRNA 3' processing enzyme., PMID:39494506
Structural basis of NEAT1 lncRNA maturation and menRNA instability., PMID:39026030
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis., PMID:38956168
Mitochondrial gene expression is required for platelet function and blood clotting., PMID:37889747
Evaluation of HNF1B, KLK3, ELAC2, TMPRSS2-ERG, and CTNNB1 polymorphisms associated with prostate cancer in samples of patients from HUPE-UERJ., PMID:37839045
ELAC2 is a functional prostate cancer risk allele., PMID:37353407
Microcystin-leucine-arginine promotes the development of gallbladder carcinoma via regulating ELAC2., PMID:37329658
Multi-omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer., PMID:37093546
Pseudohypoaldosteronism associated with hypertrophic cardiomyopathy, hypertension and thrombocytosis due to mutation in the ELAC2 gene: a case report., PMID:35946480
A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response., PMID:35451962
ELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster., PMID:34338278
ELAC2, an Enzyme for tRNA Maturation, Plays a Role in the Cleavage of a Mature tRNA to Produce a tRNA-Derived RNA Fragment During Respiratory Syncytial Virus Infection., PMID:33604354
A Study of Ser217Leu and Ala541Thr Polymorphism in the Men Afflicted with Prostate Cancer and in the Men being Suspicious of Prostate Cancer., PMID:32592348
ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control., PMID:32075755
Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy., PMID:31452838
Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3'-end processing., PMID:31045291
Arsenate-mediated G2 cell cycle arrest in U-2OS cells involves phosphorylation of human polycomb protein 2 by p38 MAPK., PMID:30317550
Chorea, psychosis, acanthocytosis, and prolonged survival associated with ELAC2 mutations., PMID:30217939
Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z., PMID:30126926
The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria., PMID:29040705
The Phenotype and Outcome of Infantile Cardiomyopathy Caused by a Homozygous ELAC2 Mutation., PMID:28441660
Annexin A10 optimally differentiates between intrahepatic cholangiocarcinoma and hepatic metastases of pancreatic ductal adenocarcinoma: a comparative study of immunohistochemical markers and panels., PMID:28357490
Cysteine Supplementation May be Beneficial in a Subgroup of Mitochondrial Translation Deficiencies., PMID:27854233
A homozygous splicing mutation in ELAC2 suggests phenotypic variability including intellectual disability with minimal cardiac involvement., PMID:27769300
Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer., PMID:27323405
Association between RNASEL, MSR1, and ELAC2 single nucleotide polymorphisms and gene expression in prostate cancer risk., PMID:27318894
4C-seq revealed long-range interactions of a functional enhancer at the 8q24 prostate cancer risk locus., PMID:26934861
Prognostic role of genetic biomarkers in clinical progression of prostate cancer., PMID:26251261
A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer., PMID:26241669
Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids., PMID:24703694
SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase., PMID:23970103
ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy., PMID:23849775
Genetic analysis of the principal genes related to prostate cancer: a review., PMID:23141781
Human pancreatic cancer fusion 2 (HPC2) 1-B3: a novel monoclonal antibody to screen for pancreatic ductal dysplasia., PMID:22811080
The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma., PMID:22406361
RNA processing in human mitochondria., PMID:21857155
A survey of green plant tRNA 3'-end processing enzyme tRNase Zs, homologs of the candidate prostate cancer susceptibility protein ELAC2., PMID:21781332
Associations of polymorphisms in HPC2/ELAC2 and SRD5A2 genes with benign prostate hyperplasia in Turkish men., PMID:21627373
Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs., PMID:21593607
Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation., PMID:21559454
RNAi knockdown of dRNaseZ, the Drosophila homolog of ELAC2, impairs growth of mitotic and endoreplicating tissues., PMID:21146608
Identification and analysis of candidate fungal tRNA 3'-end processing endonucleases tRNase Zs, homologs of the putative prostate cancer susceptibility protein ELAC2., PMID:20819227
ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies., PMID:20231859
Hereditary/familial versus sporadic prostate cancer: few indisputable genetic differences and many similar clinicopathological features., PMID:20184087
Polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in a North Indian population., PMID:20119870
For research use only. Not for human or drug use.
