Catalog No.
YHN32101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser76-Glu157
Predicted molecular weight
12.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99958
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Forkhead-related protein FKHL14, Forkhead box protein C2, MFH1, Mesenchyme fork head protein 1, FOXC2, Transcription factor FKH-14, FKHL14, MFH-1 protein
A role for pH dynamics regulating transcription factor DNA-binding selectivity., PMID:40464693
The effects of FOXC2-gene-manipulated human periodontal ligament stem cells on bone regeneration of craniofacial bone defect., PMID:40234127
Modulation of the Epithelial-mesenchymal transition process by Forkhead Box C2 in the repair of airway epithelium after injury., PMID:40065336
Adipose mesenchymal stem cell-derived extracellular vesicles alleviate renal fibrosis by reducing epithelial-mesenchymal transition via the FOXS1/Wnt/β-catenin signaling pathway., PMID:39709913
[Clinical features and genetic analysis of two Chinese pedigrees affected with Lymphedema-Distichiasis syndrome]., PMID:39653349
In Vitro Simulated Ketogenic Diet Inhibits the Proliferation and Migration of Liver Cancer Cells by Reducing Insulin Production and Down-regulating FOXC2 Expression., PMID:39344752
Molecular expression of Forkhead Box C2 gene (FOXC2) and Prospero homeobox gene (PROX-1) in oral squamous carcinoma and their correlation with clinicopathological parameters: A prospective cohort study., PMID:39157851
FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton., PMID:39012257
FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration., PMID:38989578
Fluid-Dynamic Modeling of Flow in Embryonic Tissue Indicates That Lymphatic Valve Location Is Not Consistently Determined by the Local Fluid Shear or Its Gradient., PMID:38953384
Variants in FOXC1 and FOXC2 identified in patients with conotruncal heart defects., PMID:38580085
Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals., PMID:37610429
Differential roles of FOXC2 in the trabecular meshwork and Schlemm's canal in glaucomatous pathology., PMID:37414529
Defects in vein valve PROX1/FOXC2 antithrombotic pathway in endothelial cells drive the hypercoagulable state induced by trauma and critical illness., PMID:37072887
The FOXC2 Transcription Factor: A Master Regulator of Chemoresistance in Cancer., PMID:36740986
Genetic landscape of FOXC2 mutations in lymphedema-distichiasis syndrome: Different mechanism of pathogenicity for mutations in different domains., PMID:35716761
Glioblastoma-associated microglia-derived exosomal circKIF18A promotes angiogenesis by targeting FOXC2., PMID:35637250
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer., PMID:35392966
Organoids from human tooth showing epithelial stemness phenotype and differentiation potential., PMID:35217915
FOXC2 Alleviates Myocardial Ischemia-Reperfusion Injury in Rats through Regulating Nrf2/HO-1 Signaling Pathway., PMID:34858542
Digenic Inheritance of a FOXC2 Mutation and Two PIEZO1 Mutations Underlies Congenital Lymphedema in a Multigeneration Family., PMID:34656527
H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3., PMID:34358374
Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification., PMID:34331943
FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells., PMID:34324140
Foxo1 deletion promotes the growth of new lymphatic valves., PMID:34263740
The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function., PMID:34256037
MicroRNA‑199a‑5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch., PMID:34212977
Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations., PMID:33925370
Super-enhancer Acquisition Drives FOXC2 Expression in Middle Ear Cholesteatoma., PMID:33861394
Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes., PMID:33771836
Generation of Functional Gene Knockout Melanoma Cell Lines by CRISPR-Cas9 Gene Editing., PMID:33704703
Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development., PMID:33667029
The prognostic significance of FOXC2 gene expression in cancer: A comprehensive analysis of RNA-seq data from the cancer genome atlas., PMID:33636524
MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5/FOXC2 pathway., PMID:33423166
Long non-coding RNA GClnc1 knockdown suppresses progression of epithelial ovarian cancer by recruiting FOXC2 to disrupt the NOTCH1/NF-κB/Snail pathway., PMID:33338479
MiR-1231 enhances docetaxel sensitivity to gallbladder carcinoma cells by downregulating FOXC2., PMID:33336729
[Genetic analysis and clinical phenotype of a family with lymphedema-distichiasis syndrome]., PMID:33210483
The Effect of FOXC2-AS1 on White Adipocyte Browning and the Possible Regulatory Mechanism., PMID:33193083
Lymphedema distichiasis syndrome may be caused by FOXC2 promoter-enhancer dissociation and disruption of a topological associated domain., PMID:33107170
The expression of AGGF1, FOXC2, and E-cadherin in esophageal carcinoma and their clinical significance., PMID:32925786
Effect of Insulin-Regulated FOXC2 Expression in Adipocyte Differentiation and Insulin Resistance., PMID:32821143
FOXC2 Disease Mutations Identified in Lymphedema Distichiasis Patients Impair Transcriptional Activity and Cell Proliferation., PMID:32698337
LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca2+-FAK signal pathway., PMID:32513911
Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation., PMID:32510325
Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma., PMID:32341351
LncRNA FOXC2-AS1 regulated proliferation and apoptosis of vascular smooth muscle cell through targeting miR-1253/FOXF1 axis in atherosclerosis., PMID:32271448
Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities., PMID:32259372
Circular RNA PVT1 promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells., PMID:32249539
Functional polymorphisms in FOXC2 gene and Epithelial ovarian Cancer susceptibility in Chinese population., PMID:32222147
[Genetic variant analysis of a pedigree affected with lymphedema-distichiasis syndrome]., PMID:32219830
For research use only. Not for human or drug use.
