Catalog No.
YHN31601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu303-Leu573
Predicted molecular weight
32.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99504
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eyes absent homolog 3, EYA3
Loss of circular EYA3 attenuates formaldehyde-induced cardiomyocyte pyroptosis and congenital heart defects by regulating Smad5 stability., PMID:40435734
Cryo-EM structures reveal the PP2A-B55α and Eya3 interaction that can be disrupted by a peptide inhibitor., PMID:40414499
EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis., PMID:40333987
Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment., PMID:40247147
Cryo-EM structures reveal the PP2A-B55α and Eya3 interaction that can be disrupted by a peptide inhibitor., PMID:39975004
EYA3 promotes the tumorigenesis of gastric cancer through activation of the mTORC1 signaling pathway and inhibition of autophagy., PMID:39550476
Effects of imidazole derivatives on cellular proliferation and apoptosis in myeloid leukemia., PMID:39342179
An EYA3/NF-κB/CCL2 signaling axis suppresses cytotoxic NK cells in the pre-metastatic niche to promote triple negative breast cancer metastasis., PMID:39211066
Biochemical characterization of the Eya and PP2A-B55α interaction., PMID:38796066
Thermal Proteome Profiling Reveals Insight to Antiproliferative and Pro-Apoptotic Effects of Lagunamide A in the Modulation of DNA Damage Repair., PMID:38716781
Photoperiod, but not progesterone, has a strong impact upon the transcriptome of the medio-basal hypothalamus in female goats and ewes., PMID:38556161
Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis., PMID:38042777
Potential Schizophrenia Disease-Related Genes Prediction Using Metagraph Representations Based on a Protein-Protein Interaction Keyword Network: Framework Development and Validation., PMID:37966892
Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance., PMID:37507637
The value of EYA1/3/4 in clear cell renal cell carcinoma: a study from multiple databases., PMID:37156847
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC., PMID:37128275
Both a hypoxia-inducible EYA3 and a histone acetyltransferase p300 function as coactivators of SIX5 to mediate tumorigenesis and cancer progression., PMID:35957720
Inhibitors of EYA3 Protein in Ewing Sarcoma., PMID:35633536
Molecular and epigenetic regulation of seasonal reproduction in Terai tree frog (Polypedates teraiensis)., PMID:35262895
Locus specific epigenetic modalities of random allelic expression imbalance., PMID:34504093
Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis., PMID:34419070
CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression., PMID:34395419
Daytime light spectrum affects photoperiodic induction of vernal response in obligate spring migrants., PMID:34126231
The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases., PMID:33920226
Up-regulation of circRNA_0068481 promotes right ventricular hypertrophy in PAH patients via regulating miR-646/miR-570/miR-885., PMID:33710774
Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis., PMID:33649104
A recurrent missense variant in EYA3 gene is associated with oculo-auriculo-vertebral spectrum., PMID:33475861
Circadian clock mechanism driving mammalian photoperiodism., PMID:32855407
Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation., PMID:31847183
The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension., PMID:31515519
K-ras-ERK1/2 down-regulates H2A.XY142ph through WSTF to promote the progress of gastric cancer., PMID:31151422
Temperature alters the hypothalamic transcription of photoperiod responsive genes in induction of seasonal response in migratory redheaded buntings., PMID:31121264
De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair., PMID:31045206
Neuroendocrine correlates of the critical day length response in the Soay sheep., PMID:29972606
An Immunosuppressive Role for Eya3 in TNBC., PMID:29884726
The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth., PMID:29802120
Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation., PMID:29757193
Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression., PMID:29535359
WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton., PMID:29440662
Seasonal alterations in the daily rhythms in hypothalamic expression of genes involved in the photoperiodic transduction and neurosteroid-dependent processes in migratory blackheaded buntings., PMID:28295708
Expression, Purification, and Kinetic Analysis of PTP Domains., PMID:27514799
The Eyes Absent Proteins in Developmental and Pathological Angiogenesis., PMID:26765957
Bird eyes distinguish summer from winter: Retinal response to acute photoperiod change in the night-migratory redheaded bunting., PMID:26219493
Circadian synchronization determines critical day length for seasonal responses., PMID:25957913
Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus., PMID:25565948
Hypothalamic gene switches control transitions between seasonal life history states in a night-migratory photoperiodic songbird., PMID:25261797
Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary., PMID:24891434
A photoperiodic molecular response in migratory redheaded bunting exposed to a single long day., PMID:24837606
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration., PMID:24755226
t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients., PMID:24441146
For research use only. Not for human or drug use.
