Catalog No.
YHN31501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu225-Lys336
Predicted molecular weight
15.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99496
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Huntingtin-interacting protein 2-interacting protein 3, RING-type E3 ubiquitin transferase RING2, E3 ubiquitin-protein ligase RING2, HIP2-interacting protein 3, DING, RING finger protein 1B, BAP1, Protein DinG, RING1B, RING finger protein 2, HIPI3, RNF2, RING finger protein BAP-1, RING1b
TRIM19 enhances the chemosensitivity of endometrial cancer by regulating the TBX2/NRF2 axis., PMID:40465083
RNF2 Modulates Lipid Metabolism and Inflammation in Alcohol-associated Liver Disease by Interacting with USP7., PMID:40384855
The USP43/RNF2 axis negatively regulates antiviral innate immunity by promoting TBK1 ubiquitination and degradation., PMID:40148469
RNF2 induces myeloid-derived suppressor cells chemotaxis and promotes hepatocellular carcinoma progression through the TRAF2-NF-κB signaling axis., PMID:40146286
Comparative analysis of chromatin accessibility in porcine oocytes from follicles of different sizes., PMID:39908890
GRHL3 drives radiotherapy resistance and blocks the anti-tumor response of NK and CD4+ T cells in lung squamous cell carcinoma via RNF2., PMID:39880318
A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease., PMID:39667599
METTL3-Mediated m6A Modification Regulates the Polycomb Repressive Complex 1 Components BMI1 and RNF2 in Hepatocellular Carcinoma Cells., PMID:39625677
E3 Ubiquitin Ligase Ring Finger Protein 2 Alleviates Cerebral Ischemia-Reperfusion Injury by Stabilizing Mesencephalic Astrocyte-Derived Neurotrophic Factor Through Monoubiquitination., PMID:39614674
Read-write mechanisms of H2A ubiquitination by Polycomb repressive complex 1., PMID:39537923
RNF2 promotes chondrosarcoma progression by regulating ubiquitination and degradation of CBX7., PMID:39456039
HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1., PMID:39329491
RING1 missense variants reveal sensitivity of DNA damage repair to H2A monoubiquitination dosage during neurogenesis., PMID:39256363
E3 ligase RNF2 inhibits porcine circovirus type 3 replication by targeting its capsid protein for ubiquitination-dependent degradation., PMID:39046246
Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells., PMID:38878927
Circ_0072088 promotes breast carcinoma progression via modulating miR-607/RNF2 axis., PMID:38715837
E3 ubiquitin ligase RNF2 protects polymerase ι from destabilization., PMID:38705361
Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1., PMID:38528151
YTHDF1 facilitates PRC1-mediated H2AK119ub in human ES cells., PMID:37991435
RNF2 regulates Wnt/ß-catenin signaling via TCF7L1 destabilization., PMID:37957244
An immune and epigenetics-related scoring model and drug candidate prediction for hepatic carcinogenesis via dynamic network biomarker analysis and connectivity mapping., PMID:37817777
M phase-specific interaction between SBDS and RNF2 at the mitotic spindles regulates mitotic progression., PMID:37806249
Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery., PMID:37546882
The Role of Apoptotic Genes and Protein-Protein Interactions in Triple-negative Breast Cancer., PMID:37093683
RNF2 inhibits E-Cadherin transcription to promote hepatocellular carcinoma metastasis via inducing histone mono-ubiquitination., PMID:37037816
CPT1A promotes anoikis resistance in esophageal squamous cell carcinoma via redox homeostasis., PMID:36427397
LncRNA KCNQ1OT1 enhances the radioresistance of lung squamous cell carcinoma by targeting the miR-491-5p/TPX2-RNF2 axis., PMID:36389338
The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression., PMID:36271315
The Systematic Analyses of RING Finger Gene Signature for Predicting the Prognosis of Patients with Hepatocellular Carcinoma., PMID:36199791
SPI1 mediates transcriptional activation of TPX2 and RNF2 to regulate the radiosensitivity of lung squamous cell carcinoma., PMID:36198346
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway., PMID:35933565
Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4., PMID:35390228
SBDS interacts with RNF2 and is degraded through RNF2-dependent ubiquitination., PMID:35158210
DNA methyltransferase 3 beta regulates promoter methylation of microRNA-149 to augment esophageal squamous cell carcinoma development through the ring finger protein 2/Wnt/β-catenin axis., PMID:35129056
RNAi Screen of RING/U-Box Domain Ubiquitin Ligases Identifies Critical Regulators of Tissue Regeneration in Planarians., PMID:35127720
A PRC1-RNF2 knockout punch for cancer., PMID:35121885
RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity., PMID:35121884
Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos., PMID:34982026
Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing., PMID:34857746
PRC1 Stabilizes Cardiac Contraction by Regulating Cardiac Sarcomere Assembly and Cardiac Conduction System Construction., PMID:34768802
RNF2 promotes the progression of colon cancer by regulating ubiquitination and degradation of IRF4., PMID:34670117
The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer-promoter interaction and R-loop formation., PMID:34428304
Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p/RNF2 axis., PMID:34423784
HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways., PMID:34302919
Molecular basis for RASSF10/NPM/RNF2 feedback cascade-mediated regulation of gastric cancer cell proliferation., PMID:34224728
Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells., PMID:34166371
G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production., PMID:34120140
[Plasma differentially expressed genes and bioinformatics analysis of workers occupationally exposed to mercury]., PMID:34074076
Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features., PMID:33864376
RNF2 Mediates Hepatic Stellate Cells Activation by Regulating ERK/p38 Signaling Pathway in LX-2 Cells., PMID:33816485
For research use only. Not for human or drug use.
