Catalog No.
YHN29301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys281
Predicted molecular weight
33.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TAT5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA glycosylase FPG2, NEIL3, Endonuclease 8-like 3, Endonuclease VIII-like 3, Nei-like protein 3, DNA glycosylase/AP lyase Neil3
DNA glycosylase (NEIL3) overexpression associated with low tumor immune infiltration and poor overall patient survival in endometrial cancer., PMID:40348794
NEIL3 Deficiency Enhances HCC Cell Sensitivity to Oxaliplatin by Inhibiting the Fanconi Anaemia Pathway., PMID:40263742
NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling., PMID:40035863
NEIL1: The second DNA glycosylase involved in action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine., PMID:39848343
NEIL3 Upregulated by TFAP2A Promotes M2 Polarization of Macrophages in Liver Cancer via the Mediation of Glutamine Metabolism., PMID:39342941
Enhancing cisplatin drug sensitivity through PARP3 inhibition: The influence on PDGF and G-coupled signal pathways in cancer., PMID:38830565
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair., PMID:38663144
Dissecting gene expression networks in the developing hippocampus through the lens of NEIL3 depletion., PMID:38522610
Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms., PMID:38397143
Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, thereby Promoting Angiogenesis in Hepatocellular Carcinoma., PMID:38347781
Hypoxia increases the biogenesis of IGF2BP3-bound circular RNAs., PMID:38329630
Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES., PMID:38198604
Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha., PMID:38065227
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation., PMID:37992567
DNA damage repair-related gene signature for identifying the immune status and predicting the prognosis of hepatocellular carcinoma., PMID:37923899
[Overexpression of Nei endonuclease VIII-like protein 3 in hepatocellular carcinoma indicates increased levels of immune infiltration and an unfavorable prognosis]., PMID:37872095
Transcriptional factor MAZ promotes cisplatin-induced DNA damage repair in lung adenocarcinoma by regulating NEIL3., PMID:37121465
Bioinformatics analysis of the pathogenic link between Epstein-Barr virus infection, systemic lupus erythematosus and diffuse large B cell lymphoma., PMID:37072474
NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells., PMID:36997601
YAP-mediated mechanotransduction in urinary bladder remodeling: Based on RNA-seq and CUT&Tag., PMID:36741311
Specific Blood RNA Profiles in Individuals with Acute Spinal Cord Injury as Compared with Trauma Controls., PMID:36686379
ZNF212 promotes genomic integrity through direct interaction with TRAIP., PMID:36594163
WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis., PMID:36546838
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease., PMID:36395955
Identification of Candidate Genes in Breast Cancer Induced by Estrogen Plus Progestogens Using Bioinformatic Analysis., PMID:36233194
TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability., PMID:36232914
NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway., PMID:36181299
Model of abasic site DNA cross-link repair; from the architecture of NEIL3 DNA binding domains to the X-structure model., PMID:36155818
SNHG3 regulates NEIL3 via transcription factor E2F1 to mediate malignant proliferation of hepatocellular carcinoma., PMID:36114381
Cysteine Oxidation to Sulfenic Acid in APE1 Aids G-Quadruplex Binding While Compromising DNA Repair., PMID:36037088
Genome-wide association study of SARS-CoV-2 infection in Chinese population., PMID:35927536
Identification of target and pathway of aspirin combined with Lipitor treatment in prostate cancer through integrated bioinformatics analysis., PMID:35926565
Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm., PMID:35693827
NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target., PMID:35535347
Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates., PMID:35419164
NEIL3-deficient bone marrow displays decreased hematopoietic capacity and reduced telomere length., PMID:35079641
EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3., PMID:35031058
Development of a prognostic gene signature for hepatocellular carcinoma., PMID:35030478
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice., PMID:34857879
Construction and Comprehensive Analysis of a Stratification System Based on AGTRAP in Patients with Hepatocellular Carcinoma., PMID:34840632
Upregulation of Nei-Like DNA Glycosylase 3 Predicts Poor Prognosis in Hepatocellular Carcinoma., PMID:34659404
Upregulation of mNEIL3 in Ogg1-null cells is a potential backup mechanism for 8-oxoG repair., PMID:34644377
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype., PMID:34611194
Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer., PMID:34591415
NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis., PMID:34045188
Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer., PMID:33921035
CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing., PMID:33750389
A Transcriptomic Signature for Risk-Stratification and Recurrence Prediction in Intrahepatic Cholangiocarcinoma., PMID:33725402
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development., PMID:33714552
Phase I studies of peptide vaccine cocktails derived from GPC3, WDRPUH and NEIL3 for advanced hepatocellular carcinoma., PMID:33525928
For research use only. Not for human or drug use.
