Catalog No.
YHN29101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys645-Gln835
Predicted molecular weight
23.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NEM0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Microcephalin, MCPH1
Population-based study of recurrent DNA damage response gene variants in breast cancer cases., PMID:40009290
TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway., PMID:39885205
Threonine and tyrosine kinase (TTK) mRNA and protein expression in breast cancer; prognostic significance in the neoadjuvant setting., PMID:39775836
Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers., PMID:39654522
Generation and analysis of mouse embryonic stem cells with knockout of the Mcph1 (microcephalin) gene., PMID:39280843
Microcephaly Gene Mcph1 Deficiency Induces p19ARF-Dependent Cell Cycle Arrest and Senescence., PMID:38731817
Aging-induced MCPH1 translocation activates necroptosis and impairs hematopoietic stem cell function., PMID:38632351
Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis., PMID:38605277
The impact of TP53 activation and apoptosis in primary hereditary microcephaly., PMID:37457016
The emerging role of MCPH1/BRIT1 in carcinogenesis., PMID:36845691
Prenatal Identification of a Novel Mutation in the MCPH1 Gene Associated with Autosomal Recessive Primary Microcephaly (MCPH) Using Next Generation Sequencing (NGS): A Case Report and Review of the Literature., PMID:36553323
NSD1 gene evolves under episodic selection within primates and mutations of specific exons in humans cause Sotos syndrome., PMID:36550402
The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice., PMID:36078123
Genotoxic hazard assessment of cerium oxide and magnesium oxide nanoparticles in Drosophila., PMID:35818303
MCPH1: A Novel Case Report and a Review of the Literature., PMID:35456440
Identification of Pathogenic Mutations in Primary Microcephaly- (MCPH-) Related Three Genes CENPJ, CASK, and MCPH1 in Consanguineous Pakistani Families., PMID:35281599
Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease., PMID:35132965
Multifaceted Microcephaly-Related Gene MCPH1., PMID:35053391
MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface., PMID:34850681
Genetic modulation of longitudinal change in neurocognitive function among adult glioma patients., PMID:34817796
The evolution of metazoan shelterin., PMID:34764137
MCPH1, beyond its role deciding the brain size., PMID:34705666
Tone and genes: New cross-linguistic data and methods support the weak negative effect of the "derived" allele of ASPM on tone, but not of Microcephalin., PMID:34191836
Molecular Genetics of Microcephaly Primary Hereditary: An Overview., PMID:33946187
Identification of Breast Cancer Subtype-Specific Biomarkers by Integrating Copy Number Alterations and Gene Expression Profiles., PMID:33809336
The N-terminal BRCT domain determines MCPH1 function in brain development and fertility., PMID:33542216
Generation of a MCPH1 knockout human embryonic stem cell line by CRISPR/Cas9 technology., PMID:33370873
Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly., PMID:33203878
BRIT-1 expression and its relationship with PARP-1 and CAF-1/p60 in cutaneous melanoma., PMID:33006227
Whole exome sequencing identifies rare coding variants in novel human-mouse ortholog genes in African individuals diagnosed with non-syndromic hearing impairment., PMID:32996353
Microcephaly family protein MCPH1 stabilizes RAD51 filaments., PMID:32735676
Analysis of the "centrosome-ome" identifies MCPH1 deletion as a cause of centrosome amplification in human cancer., PMID:32681070
BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K., PMID:32642299
Zika Virus Changes Methylation of Genes Involved in Immune Response and Neural Development in Brazilian Babies Born With Congenital Microcephaly., PMID:32614431
Investigation of promoter methylation of MCPH1 gene in circulating cell-free DNA of brain tumor patients., PMID:32556427
Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly., PMID:32294449
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II., PMID:32276518
Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data., PMID:32193444
Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1., PMID:32144855
[Update on autosomal recessive primary microcephaly (MCPH)-associated proteins]., PMID:31624053
A transgenic monkey model for the study of human brain evolution., PMID:31011135
MCPH1 is essential for cellular adaptation to the G2-phase decatenation checkpoint., PMID:30964711
Concurrent manifestation of oligodontia and thrombocytopenia caused by a contiguous gene deletion in 12p13.2: A three-generation clinical report., PMID:30950205
Genetic association and functional characterization of MCPH1 gene variation in bipolar disorder and schizophrenia., PMID:30859703
Tumor suppressor MCPH1 regulates gene expression profiles related to malignant conversion and chromosomal assembly., PMID:30809794
Identification of candidate gene FAM183A and novel pathogenic variants in known genes: High genetic heterogeneity for autosomal recessive intellectual disability., PMID:30500859
Novel compound heterozygous mutations in MCPH1 gene causes primary microcephaly in Saudi family., PMID:30351297
Silencing BRIT1 Facilitates the Abilities of Invasiveness and Migration in Trophoblast Cells., PMID:30337515
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1., PMID:30303738
Novel Mutations in the Asparagine Synthetase Gene (ASNS) Associated With Microcephaly., PMID:30057589
For research use only. Not for human or drug use.
