Catalog No.
YHN28401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu148-Ile490
Predicted molecular weight
41.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IWU9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neuronal tryptophan hydroxylase, TPH2, Tryptophan 5-monooxygenase 2, Tryptophan 5-hydroxylase 2, NTPH
Hyperinsulinemia-induced upregulation of adipocyte TPH2 contributes to peripheral serotonin production, metabolic dysfunction, and obesity., PMID:40455408
Resveratrol attenuates prenatal X-ray-induced microcephaly and adult depression via SIRT1-mediated senescence suppression and TPH2/5-HT pathway restoration in mice., PMID:40440905
Sirtuin 1 underlies depression-related behaviors by modulating the serotonin system in the dorsal raphe nucleus in female mice., PMID:40374143
Dynamic Model of Serotonin Presynapse and Its Application to Suicide Attempt in Patients with Bipolar Disorder., PMID:40362322
Tryptophan Hydroxylase 1 Regulates Tryptophan and Its Metabolites., PMID:40362217
[Effect of Fushen Decoction on 5-HT system and GABA expression in mouse model of PCPA-induced insomnia]., PMID:40350945
[Therapeutic effect of Ziziphi Spinosae Semen extracts on chronic unpredictable mild stress-induced depression and insomnia-like behavior in mice]., PMID:40350874
Melatonin rhythms beyond the pineal organ: gene expression of receptors and biosynthesis enzymes in wild and F1 Senegalese sole., PMID:40310543
The C1473G Mutation in the Mouse Tph2 Gene: From Molecular Mechanism to Biological Consequences., PMID:40305154
Genetics of Suicide., PMID:40282388
Effects of tea polyphenols and tea polysaccharides on improving nonylphenol-induced depression-like behavior, monoamine neurotransmitter disorder, and neuronal pyroptosis., PMID:40209346
Optogenetic Stimulation of Novel Tph2-Cre Rats Advances Insight into Serotonin's Role in Locomotion, Reinforcement, and Compulsivity., PMID:40204433
Detection of anxiety and depression-like behavior and intra-brain pathological markers in Parkinsonian cynomolgus monkeys., PMID:40194648
New molecular markers to differentiate carbon dioxide intoxication from asphyxia due to oxygen deficiency., PMID:40167862
Central Serotonin Deficiency Impairs Recovery of Sensorimotor Abilities After Spinal Cord Injury in Rats., PMID:40141402
Comparison of the Effects of Tetrahydrobiopterine, L-Tryptophan, and Iron Ions on the Thermal Stability of Wild Type and P447R Mutant Tryptophan Hydroxylase 2., PMID:40140132
Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets., PMID:40137463
Systolic and diastolic dysfunction is exacerbated by age and spinal cord injury in male and female mice with central nervous system serotonin deficiency., PMID:39968856
Acute Optogenetic Stimulation of Serotonin Neurons Reduces Cell Proliferation in the Dentate Gyrus of Mice., PMID:39937171
Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model., PMID:39923104
Probiotics and undernourishment impact on brain 5-Hydroxytryptamine system and neurotrophin BDNF in rats: Risk of depression and anxiety?, PMID:39904121
Inhaling arsenic aggravates airway hyperreactivity by upregulating PNEC-sourced 5-HT in OVA-induced allergic asthma., PMID:39854863
Electroacupuncture and Tongbian decoction ameliorate CUMS-induced depression and constipation in mice via TPH2/5-HT pathway of the gut-brain axis., PMID:39814323
Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice., PMID:39695187
The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson's disease., PMID:39634948
Socio-affective communication in Tph2-deficient rat pups: communal nesting aggravates growth retardation despite ameliorating maternal affiliation deficits., PMID:39614401
Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration., PMID:39574138
Transportation increases circulating corticosterone levels and decreases central serotonergic activity in a sex dependent manner in Pekin ducks., PMID:39541859
Human PERIOD3 variants lead to winter depression-like behaviours via glucocorticoid signalling., PMID:39528818
Acquisition and extinction of active avoidance compulsive-like behavior in mice., PMID:39492237
[Analysis of Frequencies and Subsets of Peripheral Helper T Cells in Patients with Immune Thrombocytopenia]., PMID:39479841
Ablation of CD44 Attenuates Adipogenesis in White Adipocytes via the Tryptophan 5-Hydroxylase 2/5-Hydroxytryptamine Axis to Protect Mice from High-Fat Diet-Induced Obesity., PMID:39476955
SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau., PMID:39475992
The alteration of serotonergic markers in the amygdala and raphe nuclei of oestrogen receptor β knock-out female mice., PMID:39474697
Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress., PMID:39467477
DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response., PMID:39368538
Role of serotonin neurons in the dorsal raphe nucleus in heroin self-administration and punishment., PMID:39300273
Serotonergic transmission plays differentiated roles in the rapid and sustained antidepressant-like effects of ketamine., PMID:39238235
The impact of genetic variations in the serotonergic system on symptom severity and clinical outcome in functional neurological disorders., PMID:39236646
Behavioural changes in young ovariectomized mice via GPR30-dependent serotonergic nervous system., PMID:39189108
Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation., PMID:39147805
Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer's disease., PMID:39143322
Longitudinal analysis at pre- and post-flare of T peripheral helper and T follicular helper subsets in patients with systemic lupus erythematosus., PMID:39103125
The effects of brain serotonin deficiency on the behavioral and neurogenesis-promoting effects of voluntary exercise in tryptophan hydroxylase 2 (R439H) knock-in mice., PMID:39009217
Key Enzymes of the Serotonergic System - Tryptophan Hydroxylase 2 and Monoamine Oxidase A - In the Brain of Rats Selectively Bred for a Reaction toward Humans: Effects of Benzopentathiepin TC-2153., PMID:38981704
Impact of Serotonin Deficiency on Circadian Dopaminergic Rhythms., PMID:38928178
Effect of (R)-2-Amino-6-(1R,2S)-1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydropterin-4(3H)-One and Its Structural Analogues on the Temperature Stability of Tryptophan Hydroxylase 2 with the P447R Mutation., PMID:38922549
ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway., PMID:38850708
Microbiota influence on behavior: Integrative analysis of serotonin metabolism and behavioral profile in germ-free mice., PMID:38822661
No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state., PMID:38802956
For research use only. Not for human or drug use.
