Catalog No.
YHN28201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys1003-Ser1116
Predicted molecular weight
25.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IUD2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Rab6-interacting protein 2, ELKS, ERC1, RAB6IP2, ERC-1, ELKS/Rab6-interacting/CAST family member 1, KIAA1081
Clinical, Morphologic, and Genomic Findings in Spitz Tumors With RET Fusion: A Series of 31 Cases., PMID:39986469
[Characteristics of RET gene rearrangement detected by fluorescence in situ hybridization in lung cancer]., PMID:39762169
Mitochondrial ROS modulate presynaptic plasticity in the drosophila neuromuscular junction., PMID:39721493
Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance., PMID:39314317
ZnO NPs induce miR-342-5p mediated ferroptosis of spermatocytes through the NF-κB pathway in mice., PMID:38961442
Spatially targeted chemokine exocytosis guides transmigration at lymphatic endothelial multicellular junctions., PMID:38877304
Successful Crizotinib-targeted Therapy of Pediatric Unresectable ERC1::ALK Fusion Sarcoma., PMID:38099690
Interfering with the ERC1-LL5β interaction disrupts plasma membrane-Associated platforms and affects tumor cell motility., PMID:37437062
Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation., PMID:37252973
Frequent EGFR exon 20 insertion in the so-called peripheral-type squamous cell neoplasm of uncertain malignant potential: a variant of bronchiolar adenoma or under-recognised entity?, PMID:36864007
Integrative In Silico Investigation Reveals the Host-Virus Interactions in Repurposed Drugs Against SARS-CoV-2., PMID:36303774
Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma., PMID:36255664
A conserved enzyme of smut fungi facilitates cell-to-cell extension in the plant bundle sheath., PMID:36224193
Durable Response to Trametinib in an Infant With ERC1-BRAF Infantile Fibrosarcoma-Like Tumor: A Case Report and Literature Review of BRAF-Altered Infantile Fibrosarcoma-Like Tumors., PMID:36103644
Identification of RET fusions in a Chinese multicancer retrospective analysis by next-generation sequencing., PMID:34710947
Effectiveness of bortezomib and temozolomide for eradication of recurrent human glioblastoma cells, resistant to radiation., PMID:34689859
Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins., PMID:33761347
Pitfalls in RET Fusion Detection Using Break-Apart FISH Probes in Papillary Thyroid Carcinoma., PMID:33382428
Identification and Validation of Potential miRNAs, as Biomarkers for Sepsis and Associated Lung Injury: A Network-Based Approach., PMID:33182754
ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization., PMID:32937583
Detection of NTRK1/3 Rearrangements in Papillary Thyroid Carcinoma Using Immunohistochemistry, Fluorescent In Situ Hybridization, and Next-Generation Sequencing., PMID:32880785
Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data., PMID:32768867
Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization., PMID:32737449
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals., PMID:32521280
Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons., PMID:32210230
Double deletion of the active zone proteins CAST/ELKS in the mouse forebrain causes high mortality of newborn pups., PMID:31996256
The sake yeast YHR032W/ERC1 allele contributes to the regulation of the tetrahydrofolate content in the folate synthetic pathway in sake yeast strains., PMID:31961264
The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase., PMID:31537859
Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells., PMID:31500835
Molecular and clinical analysis of Chinese patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer., PMID:31444835
Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes., PMID:31243098
Identification of nicotinamide aminonaphthyridine compounds as potent RET kinase inhibitors and antitumor activities against RET rearranged lung adenocarcinoma., PMID:31226468
ELKS/Voltage-Dependent Ca2+ Channel-β Subunit Module Regulates Polarized Ca2+ Influx in Pancreatic β Cells., PMID:30699350
Drug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses., PMID:30679503
Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization., PMID:30404858
Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance., PMID:30190286
CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse., PMID:29996090
Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen., PMID:29946045
ELKS active zone proteins as multitasking scaffolds for secretion., PMID:29491150
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites., PMID:29398114
Identification of a membrane-less compartment regulating invadosome function and motility., PMID:29348417
Synaptic weight set by Munc13-1 supramolecular assemblies., PMID:29230050
Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes., PMID:28607494
Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons., PMID:28066185
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice., PMID:27889896
Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover., PMID:27659488
Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains., PMID:27567046
Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking., PMID:27537483
MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis., PMID:27528609
ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains., PMID:27253063
For research use only. Not for human or drug use.
