Catalog No.
YHN27901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu87-His304
Predicted molecular weight
27.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86X52
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N-acetylgalactosaminyltransferase 1, Chondroitin sulfate synthase 1, KIAA0990, ChSy-1, CHSY1, N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1, Chondroitin glucuronyltransferase 1, Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1, CSS1, Chondroitin synthase 1, CHSY
Genomic insights into adaptation to bipedal saltation and desert-like habitats of jerboas., PMID:38902451
Atorvastatin's Therapeutic Potential in Atherosclerosis: Inhibiting TGF-β-Induced Proteoglycan Glycosaminoglycan Chain Elongation through ROS-ERK1/2-Smad2L Signaling Pathway Modulation in Vascular Smooth Muscle Cells., PMID:38459733
CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening., PMID:37749638
Function and mechanism of MCM8 in the development and progression of colorectal cancer., PMID:37710286
Identification of co-diagnostic effect genes for aortic dissection and metabolic syndrome by multiple machine learning algorithms., PMID:37684281
Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells., PMID:37532579
15q26.3 deletions distal to IGF1R cause growth retardation, congenital heart defect and skeletal anomalies: Case report and review of literature., PMID:37434556
Cardioprotective effect of tamoxifen and raloxifene: Preventing proteoglycan synthesis by modulating non-canonical TGF-β signalling through NADPH oxidase and ERK phosphorylation., PMID:37307710
Targeting Chondroitin Sulphate Synthase 1 (Chsy1) Promotes Axon Growth Following Neurorrhaphy by Suppressing Versican Accumulation., PMID:37175152
Hsa_circ_0005050 regulated the progression of oral squamous cell carcinoma via miR-487a-3p/CHSY1 axis., PMID:36643258
Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis., PMID:36047655
Endothelin-1 dependent expression of GAG genes involves NOX and p38 mediated Smad linker region phosphorylation., PMID:35527471
Effect of Genetic Polymorphism Including NUP153 and SVEP1 on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects., PMID:35501592
Chsy1 deficiency reduces extracellular matrix productions and aggravates cartilage injury in osteoarthritis., PMID:35390446
Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor., PMID:34982346
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer., PMID:34966741
Targeting Chondroitin Sulfate Reduces Invasiveness of Glioma Cells by Suppressing CD44 and Integrin β1 Expression., PMID:34944101
EGF Receptor Transactivation by Endothelin-1 Increased CHSY-1 Mediated by NADPH Oxidase and Phosphorylation of ERK1/2., PMID:34837677
LncRNA LINC01094 contributes to glioma progression by modulating miR-224-5p/CHSY1 axis., PMID:34716872
CHSY1 is upregulated and acts as tumor promotor in gastric cancer through regulating cell proliferation, apoptosis, and migration., PMID:34412565
Artemisinin inhibits glycosaminoglycan chain synthesizing gene expression but not proliferation of human vascular smooth muscle cells., PMID:32868072
Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability., PMID:32019907
FOXM1-Activated LINC01094 Promotes Clear Cell Renal Cell Carcinoma Development via MicroRNA 224-5p/CHSY1., PMID:31767633
Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice., PMID:31754016
Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation., PMID:31290007
Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1., PMID:30809816
Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes., PMID:30423352
Transforming growth factor-β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells., PMID:30417274
Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5'-untraslated region., PMID:30401686
CHSY1 promoted proliferation and suppressed apoptosis in colorectal cancer through regulation of the NFκB and/or caspase-3/7 signaling pathway., PMID:30344756
Tumor-dependent Effects of Proteoglycans and Various Glycosaminoglycan Synthesizing Enzymes and Sulfotransferases on Patients' Outcome., PMID:29984655
Flavopiridol Inhibits TGF-β-Stimulated Biglycan Synthesis by Blocking Linker Region Phosphorylation and Nuclear Translocation of Smad2., PMID:29438988
Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height., PMID:29205154
CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway., PMID:28652022
Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes., PMID:28569157
Global chondrocyte gene expression after a single anabolic loading period: Time evolution and re-inducibility of mechano-responses., PMID:28369921
Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling., PMID:28096061
A FURTHER PATIENT OF PURE 15q DELETION: CLINICAL AND MOLECULAR CYTOGENETIC FINDINGS., PMID:27192887
Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance., PMID:26997434
TGF-β Induces Up-Regulation of Chondroitin Sulfate Synthase 1 (CHSY1) in Nucleus Pulposus Cells Through MAPK Signaling., PMID:26356269
Distal Partial Trisomy 15q26 and Partial Monosomy 16p13.3 in a 36-Year-Old Male with Clinical Features of Both Chromosomal Abnormalities., PMID:25871641
Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture., PMID:24338203
A novel CHSY1 gene mutation underlies Temtamy preaxial brachydactyly syndrome in a Pakistani family., PMID:24269551
A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1., PMID:23811343
Expression of chondroitin/dermatan sulfate glycosyltransferases during early zebrafish development., PMID:23703795
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse., PMID:23412898
Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development., PMID:22952769
Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning., PMID:22280990
Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling., PMID:21129728
Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling., PMID:21129727
For research use only. Not for human or drug use.
