Catalog No.
YHN27601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly217-Ser363
Predicted molecular weight
18.48 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6IE81
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1807, Jade family PHD finger protein 1, JADE1, PHD finger protein 17, Protein Jade-1, PHF17
Wnt5a regulates the expression of developmental genes in the adult retina following optic nerve crush injury., PMID:40079114
Jade1 and the HBO1 complex are spatial-selective cofactors of Oct4., PMID:39574712
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions., PMID:39543485
Identification and functional characterization of lncRNAs involved in human monocyte-to-macrophage differentiation., PMID:39429195
Protective effect of Sasa veitchii extract against all-trans-retinoic acid-induced inhibition of proliferation of cultured human palate cells., PMID:38962411
HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription., PMID:38670996
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression., PMID:38462163
Guiding the HBO1 complex function through the JADE subunit., PMID:38448574
JADE1 is dispensable for the brain development in mice., PMID:38171233
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB., PMID:37808733
MicroRNA-155-5p Targets JADE-1, Promoting Proliferation, Migration, and Invasion in Clear Cell Renal Cell Carcinoma Cells., PMID:37175531
Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components., PMID:36806742
Evaluation of differentially expressed genes during replication using gene expression landscape of monkeypox-infected MK2 cells: A bioinformatics and systems biology approach to understanding the genomic pattern of viral replication., PMID:36724696
AZD5153, a Bivalent BRD4 Inhibitor, Suppresses Hepatocarcinogenesis by Altering BRD4 Chromosomal Landscape and Modulating the Transcriptome of HCC Cells., PMID:35399501
Genome-wide association study and functional validation implicates JADE1 in tauopathy., PMID:34719765
HBO1 is a versatile histone acyltransferase critical for promoter histone acylations., PMID:34259319
CPEB3 regulates neuron-specific alternative splicing and involves neurogenesis gene expression., PMID:33318303
Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer., PMID:32559418
Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24+CD44+ pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway., PMID:32351328
Structural basis for renal cancer by the dynamics of pVHL-dependent JADE1 stabilization and β-catenin regulation., PMID:30528740
The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate., PMID:29382722
Correlation analysis of VHL and Jade-1 gene expression in human renal cell carcinoma., PMID:28352799
Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2., PMID:28334966
Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans., PMID:28134766
Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation., PMID:27160456
Structure, function and regulation of jade family PHD finger 1 (JADE1)., PMID:27155521
Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression., PMID:26919559
Jade-1: its structure, regulation and functions in the renal cancer., PMID:26695694
The novel function of JADE1S in cytokinesis of epithelial cells., PMID:26151225
HBO1:JADE1 at the cell cycle chromatin crossroads., PMID:25483181
Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity., PMID:25100726
Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex., PMID:24739512
A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation., PMID:24097061
Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity., PMID:24065767
Candidate tumor suppressor and pVHL partner Jade-1 binds and inhibits AKT in renal cell carcinoma., PMID:23824745
Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration., PMID:23159946
Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1., PMID:23001567
The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate β-catenin signaling., PMID:22654112
Expression and clinical significance of von Hippel-Lindau downstream genes: Jade-1 and β-catenin related to renal cell carcinoma., PMID:22516360
HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin., PMID:20129055
Beta-catenin gets jaded and von Hippel-Lindau is to blame., PMID:19217300
HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail., PMID:19187766
Differential gene expression triggered by highly cytotoxic alpha-emitter-immunoconjugates in gastric cancer cells., PMID:19139817
One hit, two outcomes for VHL-mediated tumorigenesis., PMID:18830218
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL., PMID:18806787
Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex., PMID:18684714
Role of the VHL (von Hippel-Lindau) gene in renal cancer: a multifunctional tumour suppressor., PMID:18481984
Jade-1, a candidate renal tumor suppressor that promotes apoptosis., PMID:16046545
von Hippel-Lindau partner Jade-1 is a transcriptional co-activator associated with histone acetyltransferase activity., PMID:15502158
Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent., PMID:14973063
For research use only. Not for human or drug use.
