Catalog No.
YHE76201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu76-Asp423
Predicted molecular weight
42.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P50440
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Glycine amidinotransferase, mitochondrial, L-arginine:glycine amidinotransferase, GATM, Transamidinase, AGAT
Role of GATM/creatine as energy reserves in the poll gland and rutting activities in male Bactrian camel., PMID:40484098
Gene delivery of AGAT and GAMT boosts creatine levels in creatine transporter deficiency patient fibroblasts., PMID:40338959
Germline-Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality., PMID:40019487
Assessing Creatine-Related Gene Expression in Kidney Disease: Can Available Data Give Insights into an Old Discussion?, PMID:40004980
Enhancing cardiac repair post-myocardial infarction: a study on GATM/Gel hydrogel therapeutics., PMID:39937362
The hidden potential of solasonine: Targeting non-small cell lung cancer (NSCLC) metastasis through GATM and Smad2 pathways., PMID:39922150
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway., PMID:39525575
Cefadroxil Targeting of SLC15A2/PEPT2 Protects From Colistin Nephrotoxicity., PMID:39522761
A novel biomarker GATM suppresses proliferation and malignancy of cholangiocarcinoma cells by modulating the JNK/c-Jun signalling pathways., PMID:39296238
Association between GATM gene polymorphism and progression of chronic kidney disease: a mitochondrial related genome-wide Mendelian randomization study., PMID:39284843
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
Complex phenotype in Fanconi renotubular syndrome type 1: Hypophosphatemic rickets as the predominant presentation., PMID:38876250
Functional metabolomics reveals arsenic-induced inhibition of linoleic acid metabolism in mice kidney in drinking water., PMID:38636836
ClinGen variant curation expert panel recommendations for classification of variants in GAMT, GATM and SLC6A8 for cerebral creatine deficiency syndromes., PMID:38452609
ALDH2 is a novel biomarker and exerts an inhibitory effect on melanoma., PMID:38378847
Transcriptomic and proteomic fingerprints induced by the fungicides difenoconazole and metalaxyl in zebrafish embryos., PMID:38135202
Inherited non-FGF23-mediated phosphaturic disorders: A kidney-centric review., PMID:38042745
Clinical features of germline BRCA1/2 or ATM pathogenic variant positive pancreatic cancer in Japan., PMID:37914629
Microarray analysis identifies human apoA-IMilano and apoA-II as determinants of the liver gene expression related to lipid and energy metabolism., PMID:37858836
Walnut consumption and gut microbial metabolism: Results of an exploratory analysis from a randomized, crossover, controlled-feeding study., PMID:37826992
Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications., PMID:37370109
Somatic and germline ATM variants in non-small-cell lung cancer: Therapeutic implications., PMID:37343657
RNA-Sequencing Reveals Gene Expression and Pathway Signatures in Umbilical Cord Blood Affected by Birth Delivery Mode., PMID:37325709
Perspectives of Rare Disease Experts on Newborn Genome Sequencing., PMID:37155167
Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa., PMID:37101650
Age-stratified proteomic characteristics and identification of promising precise clinical treatment targets of colorectal cancer., PMID:36870673
Creatine Deficiency Disorders: Phenotypes, Genotypes, Diagnosis, and Treatment Outcomes., PMID:36856349
DIA-MS Based Proteomics Combined with RNA-Seq Data to Unveil the Mitochondrial Dysfunction in Human Glioblastoma., PMID:36838582
Proteomic analysis of spinal cord tissue in a rat model of cancer-induced bone pain., PMID:36545122
Guanidino acid hydrolysis by the human enzyme annotated as agmatinase., PMID:36543883
Reprogramming alternative macrophage polarization by GATM-mediated endogenous creatine synthesis: A potential target for HDM-induced asthma treatment., PMID:36177049
Genetic and clinical profile of patients with hypophosphatemic rickets., PMID:35738466
Transcriptome Analysis of Breast Muscle Reveals Pathways Related to Protein Deposition in High Feed Efficiency of Native Turkeys., PMID:35625086
Identification of novel variations in SLC6A8 and GAMT genes causing cerebral creatine deficiency syndrome., PMID:35588794
GATM-Mediated Creatine Biosynthesis Enables Maintenance of FLT3-ITD-Mutant Acute Myeloid Leukemia., PMID:34635505
Association between pathogenic germline mutations in BRCA2 and ATM and tumor-infiltrating lymphocytes in primary prostate cancer., PMID:34533610
Efficacy of systemic therapies in men with metastatic castration resistant prostate cancer harboring germline ATM versus BRCA2 mutations., PMID:34516663
Investigation of Diagnostic Biomarkers for Osteoporosis Based on Differentially Expressed Gene Profile with QCT and mDixon-Quant Techniques., PMID:34516037
GATM and GAMT synthesize creatine locally throughout the mammalian body and within oligodendrocytes of the brain., PMID:34418357
Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM., PMID:34349672
iTRAQ-based quantitative proteomic analysis reveals the toxic mechanism of diclofenac sodium on the kidney of broiler chicken., PMID:34229076
Polymorphism in the GATM Locus Associated with Dialysis-Independent Chronic Kidney Disease but Not Dialysis-Dependent Kidney Failure., PMID:34071541
Creatine promotes cancer metastasis through activation of Smad2/3., PMID:33811821
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer., PMID:33596409
Genomic Features and Classification of Homologous Recombination Deficient Pancreatic Ductal Adenocarcinoma., PMID:33524400
Correlation between single-nucleotide polymorphisms and statin-induced myopathy: a mixed-effects model meta-analysis., PMID:33150478
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline., PMID:33137338
Hypoxia-inducible factor (HIF1alpha) inhibition modulates cumulus cell function and affects bovine oocyte maturation in vitro†., PMID:33095229
Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines., PMID:32787775
For research use only. Not for human or drug use.
