Catalog No.
YHB03501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met380-Gly566
Predicted molecular weight
23.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60890
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OPHN1, Oligophrenin-1
Exome Sequencing of Consanguineous Pashtun Families With Familial Epilepsy Reveals Causative and Candidate Variants in TSEN54, MOCS2, and OPHN1., PMID:39400946
Effect of the OPHN1 novel variant c.1025+1 G>A on RNA splicing: insights from a minigene assay., PMID:38956616
Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness., PMID:37760343
Nexus between genome-wide copy number variations and autism spectrum disorder in Northeast Han Chinese population., PMID:36750796
Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus., PMID:36708754
Positive Allosteric Modulation of mGlu1 Reverses Cocaine-Induced Behavioral and Synaptic Plasticity Through the Integrated Stress Response and Oligophrenin-1., PMID:35871097
Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1., PMID:35563851
Identification of epilepsy concomitant candidate genes recognized in Saudi epileptic patients., PMID:35363364
Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis., PMID:35277867
A Clinical and Integrated Genetic Study of Isolated and Combined Dystonia in Taiwan., PMID:35041927
Androgen deprivation‑induced OPHN1 amplification promotes castration‑resistant prostate cancer., PMID:34738630
Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression., PMID:34545067
Ophn1 regulation of prefrontal inhibition: A mechanism for stress susceptibility in intellectual disability., PMID:34015262
Drosophila Graf regulates mushroom body β-axon extension and olfactory long-term memory., PMID:33892766
Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex., PMID:33831348
Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression., PMID:33678127
Novel unconventional variants expand the allelic spectrum of OPHN1 gene., PMID:33638601
Altered Cl- homeostasis hinders forebrain GABAergic interneuron migration in a mouse model of intellectual disability., PMID:33376209
Exon 21 deletion in the OPHN1 gene in a family with syndromic X-linked intellectual disability: Case report., PMID:32872024
Plasma cell-free DNA-based predictors of response to abiraterone acetate/prednisone and prognostic factors in metastatic castration-resistant prostate cancer., PMID:32203070
ROCK/PKA Inhibition Rescues Hippocampal Hyperexcitability and GABAergic Neuron Alterations in a Oligophrenin-1 Knock-Out Mouse Model of X-Linked Intellectual Disability., PMID:32098904
Tobramycin promotes fracture healing by accelerating osteogenesis differentiation of MSCs through activating Wnt/β-catenin pathway., PMID:31124631
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors., PMID:30001237
Expanding the phenotypic spectrum associated with OPHN1 variants., PMID:29960046
Platelet Rho GTPase regulation in physiology and disease., PMID:29799302
Expanding the phenotypic spectrum associated with OPHN1 mutations: Report of 17 individuals with intellectual disability but no cerebellar hypoplasia., PMID:29510240
RUNX-2, OPN and OCN expression induced by grey and white mineral trioxide aggregate in normal and hypertensive rats., PMID:29143348
Protein Kinase A Deregulation in the Medial Prefrontal Cortex Impairs Working Memory in Murine Oligophrenin-1 Deficiency., PMID:29030432
Differential expression of microRNAs and their possible roles in patients with chronic idiopathic urticaria and active hives., PMID:28583230
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability., PMID:28088401
Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability., PMID:27146843
Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb., PMID:27742778
Large in-frame intragenic deletion of OPHN1 in a male patient with a normal intelligence quotient score., PMID:27390894
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function., PMID:27160703
Oligophrenin1 protects mice against myocardial ischemia and reperfusion injury by modulating inflammation and myocardial apoptosis., PMID:27117132
Effect of Combined Action of Extracellular ATP and Elevated Calcium on Osteogenic Differentiation of Primary Cultures From Rat Calvaria., PMID:27038365
Increased STAG2 dosage defines a novel cohesinopathy with intellectual disability and behavioral problems., PMID:26443594
Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells., PMID:26245966
RhoGAPs and Rho GTPases in platelets., PMID:25639730
Loss of oligophrenin1 leads to uncontrolled Rho activation and increased thrombus formation in mice., PMID:25556321
Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa histone deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1., PMID:25511694
Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer., PMID:25170626
The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation., PMID:24966368
Intragenic rearrangements in X-linked intellectual deficiency: results of a-CGH in a series of 54 patients and identification of TRPC5 and KLHL15 as potential XLID genes., PMID:24817631
Reduced gamma oscillations in a mouse model of intellectual disability: a role for impaired repetitive neurotransmission?, PMID:24800744
[XCT790 inhibits rat vascular smooth muscle cells proliferation through down-regulating the expression of estrogen-related receptor alpha]., PMID:24761608
Decreased expression of genes associated with memory and x-linked mental retardation in boys with non-syndromic cryptorchidism and high infertility risk., PMID:24715854
Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development., PMID:24637888
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway., PMID:24298161
For research use only. Not for human or drug use.
