Catalog No.
YHA96701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys56-Lys173
Predicted molecular weight
16.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60663
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LIM/homeobox protein 1.2, LIM/homeobox protein LMX1B, LMX1B, LIM homeobox transcription factor 1-beta, LMX-1.2
Identification of a novel missense variant in the LMX1B gene associated with nail-patella syndrome in a Chinese family., PMID:40421384
A novel variation in the LMX1B gene with nail-patella syndrome., PMID:40174274
LMX1B missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization., PMID:40168115
LMX1B haploinsufficiency due to variants in the 5'UTR as a cause of Nail-Patella syndrome., PMID:39939609
AMPK Phosphorylates LMX1b to Regulate a Brainstem Neurogenic Network Important for Control of Breathing in Neonatal Mice., PMID:39796072
The molecular mechanism of Xiaoyaosan in treating major depressive disorder: Integrated analysis of DNA methylation and RNA sequencing of the arcuate nucleus in rats., PMID:39675591
Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis., PMID:39651757
Molecular Ontology of the Nucleus of Solitary Tract., PMID:39629676
A multicenter study investigating the genetic analysis of childhood steroid-resistant nephrotic syndrome: Variants in COL4A5 may not be coincidental., PMID:39625990
Focal segmental glomerulosclerosis associated with undescribed mutation in the LMX1B gene., PMID:39490407
Genetic polymorphisms of LMX1B and MLXIP are associated with hip osteoarthritis in the Chinese population., PMID:39263770
Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach., PMID:39123228
A Family With Nail-Patella Syndrome Caused by a Germline Mosaic Deletion of LMX1B., PMID:39038913
Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis., PMID:38766227
Exome sequencing of 1190 non-syndromic clubfoot cases reveals HOXD12 as a novel disease gene., PMID:38663984
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice., PMID:38528118
Nail-patella syndrome with nephropathy in a de novo LMX1B mutation: triangular lunula of the thumb and lack of finger creases as clues., PMID:38478172
Case report: A novel R246L mutation in the LMX1B homeodomain causes isolated nephropathy in a large Chinese family., PMID:38457557
A deletion variant in LMX1B causing nail-patella syndrome in Japanese twins., PMID:38424113
The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration., PMID:38288855
High throughput functional profiling of genes at intraocular pressure loci reveals distinct networks for glaucoma., PMID:38272457
In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25., PMID:38051653
De novo enhancer deletion of LMX1B produces a mild nail-patella clinical phenotype., PMID:37899549
Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis., PMID:37749624
ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease., PMID:37312406
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons., PMID:37036692
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience., PMID:37014324
Prolonged Differentiation of Neuron-Astrocyte Co-Cultures Results in Emergence of Dopaminergic Neurons., PMID:36835019
Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease., PMID:36820885
Derivation of the Immortalized Cell Line UM51-PrePodo-hTERT and Its Responsiveness to Angiotensin II and Activation of the RAAS Pathway., PMID:36766685
Enhancing Neurological Competence of Nanoencapsulated Cordyceps/Turmeric Extracts in Human Neuroblastoma SH-SY5Y Cells., PMID:36660588
Identification of ARMH4 and WIPF3 as human podocyte proteins with potential roles in immunomodulation and cytoskeletal dynamics., PMID:36649229
Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity., PMID:36641754
Targeted Methylation Profiling of Single Laser-Capture Microdissected Post-Mortem Brain Cells by Adapted Limiting Dilution Bisulfite Pyrosequencing (LDBSP)., PMID:36555213
Simultaneous kidney and pancreas transplantation in a patient with nail-patella syndrome and insulin-dependent diabetes., PMID:36434354
Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder., PMID:36272053
Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1β-Induced Human Osteoarthritis Chondrocytes through NF-κB and NLRP3 Signal Pathway., PMID:36133743
Triphenyl phosphate disturbs placental tryptophan metabolism and induces neurobehavior abnormal in male offspring., PMID:36007322
Hippocampal DNA Methylation, Epigenetic Age, and Spatial Memory Performance in Young and Old Rats., PMID:35917578
LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer., PMID:35832649
Case Report: Inversion of LMX1B - A Novel Cause of Nail-Patella Syndrome in a Swedish Family and a Longtime Follow-Up., PMID:35769074
A novel LMX1B mutation: nail-patella syndrome manifesting with isolated nail disorders., PMID:35643888
Transcriptional preservation of serotonergic connectivity may shed light on neurodegeneration., PMID:35624030
Transcription Factor Lmx1b Negatively Regulates Osteoblast Differentiation and Bone Formation., PMID:35563615
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development., PMID:35552394
Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity., PMID:35471146
An adult-stage transcriptional program for survival of serotonergic connectivity., PMID:35443166
Maternal Herpesviridae infection during pregnancy alters midbrain dopaminergic signatures in adult offspring., PMID:35417751
hsa-miR-206b Involves in the Development of Papillary Thyroid Carcinoma via Targeting LMX1B., PMID:35342753
Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary., PMID:35337816
For research use only. Not for human or drug use.
