Catalog No.
YHN32001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly61-Arg371
Predicted molecular weight
38.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99873
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IR1B4, Protein arginine N-methyltransferase 1, HRMT1L2, HMT2, Interferon receptor 1-bound protein 4, PRMT1, Histone-arginine N-methyltransferase PRMT1
Hederagenin promotes SIRT6 to attenuate epidural scar formation by aggravating PRMT1 deacetylation., PMID:40511498
PRMT1 inhibition enhances the cardioprotective effect of adipose-derived mesenchymal stem cells against myocardial infarction through RUNX1., PMID:40462184
Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibit gastric cancer based on WGCNA and machine algorithms., PMID:40446574
PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents., PMID:40413955
PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein., PMID:40401713
Arginine methylation patterns in LUAD: defining prognostic subtypes and relevance to immunotherapy., PMID:40399547
PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer., PMID:40393971
Prmt1-mediated methylation regulates Ncoa4 stability to transactivate Adamts genes and promote bone extracellular matrix degradation in chronic hematogenous osteomyelitis., PMID:40346625
PRMT1 Upregulates SIRT6 by Enhancing Arginine Methylation of E2F7 to Inhibit Vascular Smooth Muscle Cell Senescence in Aortic Dissection., PMID:40298071
PRMT1-Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma., PMID:40270464
Bcl-xL is important for the antiapoptotic activity of Gfi1 and is upregulated by Gfi1 through hemgn., PMID:40262274
Discovery of a first-in-class protein arginine methyltransferase 1 (PRMT1) degrader for nonenzymatic functions studies., PMID:40245820
Aloe-Emodin Relieves Myocardial Intracellular Calcium Homeostasis Imbalance Induced by High-Fat Diet via Protein Arginine Methyltransferase/ Ca2+/Calmodulin- Dependent Protein Kinase II Signaling Pathway in Rats., PMID:40231528
Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation., PMID:40192801
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription., PMID:40173041
PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF-κB Signaling., PMID:40135804
PRMT1-mediated modification of H4R3me2a promotes liver cancer progression by enhancing the transcriptional activity of SOX18., PMID:40130992
Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells., PMID:40124968
Protein Arginine Methyltransferase 1: A Multi-Purpose Player in the Development of Cancer and Metabolic Disease., PMID:40001488
Therapeutic Potential of PRMT1 as a Critical Survival Dependency Target in Multiple Myeloma., PMID:39975313
Arginine Methylation by PRMT1 Affects ADAMTS13 Secretion and Enzymatic Activity., PMID:39945068
Discovery of novel PRMT1 inhibitors: a combined approach using AI classification model and traditional virtual screening., PMID:39906150
Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury., PMID:39901028
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression., PMID:39890802
PRMT1-methylated MSX1 phase separates to control palate development., PMID:39843447
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy., PMID:39817908
Baicalein attenuates ovalbumin-induced allergic rhinitis through the activation of nuclear receptor subfamily 4 group a member 1., PMID:39808359
Molecular Characterization and Potential Inhibitors Prediction of Protein Arginine Methyltransferase-2 in Carcinoma: An Insight from Molecular Docking, ADMET Profiling and Molecular Dynamics Simulation Studies., PMID:39802857
PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3., PMID:39786757
PRMT1-mediated BRD4 arginine methylation and phosphorylation promote partial epithelial-mesenchymal transformation and renal fibrosis., PMID:39775984
Positive feedback between arginine methylation of YAP and methionine transporter SLC43A2 drives anticancer drug resistance., PMID:39747898
Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5., PMID:39741976
Inhibition of HIF-1α ameliorates pulmonary fibrosis by suppressing M2 macrophage polarization through PRMT1/STAT6 signals., PMID:39733638
Targeting PRMT1 Reduces Cancer Persistence and Tumor Relapse in EGFR- and KRAS-Mutant Lung Cancer., PMID:39699269
PRMT1-mediated methylation regulates MLL2 stability and gene expression., PMID:39698834
PRMT1 Promotes the Self-renewal of Leukemia Stem Cells by Regulating Protein Synthesis., PMID:39668478
PRMT1 alleviates isoprenaline-induced myocardial hypertrophy by methylating SRSF1., PMID:39659162
PRMT1-mediated methylation of ME2 promotes hepatocellular carcinoma growth by inhibiting ubiquitination., PMID:39528487
The role of PRMT1 in cellular regulation and disease: Insights into biochemical functions and emerging inhibitors for cancer therapy., PMID:39521191
Oligomerization of protein arginine methyltransferase 1 and its functional impact on substrate arginine methylation., PMID:39491649
Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins., PMID:39414979
PRMT1 Modulates Alternative Splicing to Enhance HPV18 mRNA Stability and Promote the Establishment of Infection., PMID:39386465
PRMT1-mediated arginine methylation promotes YAP activation and hepatocellular carcinoma proliferation., PMID:39367565
Overview of PRMT1 modulators: Inhibitors and degraders., PMID:39316844
PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma., PMID:39300069
PRMT1 promotes radiotherapy resistance in glioma stem cells by inhibiting ferroptosis., PMID:39254902
P4HB regulates the TGFβ/SMAD3 signaling pathway through PRMT1 to participate in high glucose-induced epithelial-mesenchymal transition and fibrosis of renal tubular epithelial cells., PMID:39251943
Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1., PMID:39250434
Role of PRMT1 and PRMT5 in Breast Cancer., PMID:39201539
Metal-polyphenol-network coated R612F nanoparticles reduce drug resistance in hepatocellular carcinoma by inhibiting stress granules., PMID:39198406
For research use only. Not for human or drug use.
